Biochemistry, Biophysics and Molecular Biology

Function of JARID2 in bovines during early embryonic development

Editor rating: 7 / 10

Shao-Chen Sun –– This work provided the basic roles of JARID2 on bovine oocytes.
Profiling soil microbial communities with next-generation sequencing: the influence of DNA kit selection and technician technical expertise

Editor rating: 7 / 10

Juan Riesgo-Escovar –– It addresses methodological problems that hinder comparison of these type of results from different publications.
Simulations indicate that scores of lionfish (Pterois volitans) colonized the Atlantic Ocean

Editor rating: 7 / 10

Mark Hixon –– This study provides insight on the size of the founding introduced population that gave rise to one of the worst marine invasions in history.
Multi-scale and multi-site resampling of a study area in spatial genetics: implications for flying insect species

Editor rating: 7 / 10

Michael Huston –– Some of the logistical constraints on obtaining adequate genetic samples and interpreting their patterns over large complex regions can be addressed by multi-scale spatial analyses of the data.
In silico identification of off-target pesticidal dsRNA binding in honey bees (Apis mellifera)

Editor rating: 9 / 10

Ilaria Negri –– The article deals with a new biotechnology with broad application in agriculture but with a potential risk for non target insects
Shift of symbiont communities in Acropora tenuis juveniles under heat stress

Editor rating: 7 / 10

Joseph Gillespie –– This is important work on a small scale, pertaining to the biology of these corals. But it is further ecological significance, and thus will be of interest to marine biologists ecologists and environmental scientists.
Epigenetic considerations in aquaculture

Editor rating: 8 / 10

Mohammad Shamsur Rahman –– New approach to improve aquaculture production!
Stem-loop structure preference for site-specific RNA editing by APOBEC3A and APOBEC3G

Editor rating: 7 / 10

Christopher Jolly –– Whether to not members of the APOBEC family of cytidine deaminases, which includes AID, dominate RNA or DNA or both has been a hotly debated topic since the publication of AID's role in antibody maturation in 2000. The overwhelming evidence in favour of Neuberger's DNA deamination model that emerged from 2001 onwards has produced the paradigm that APOBECs and AID perform their biological function by deaminating DNA. Nonetheless, this paper follows up earlier studies by the same authors that have demonstrated RNA-editing functions for APOBEC3A by demonstrating that substrate specificity for RNA-editing by APOBEC3A and G is dictated by RNA secondary structure, and not by the primary sequence flanking deamination sites. A bona fide RNA-editing function for APOBECs has major implications for their roles in cancer; it seems likely that mammalian cytidine deaminases will continue to surprise us for some time to come.
A Cdk1 phosphomimic mutant of MCAK impairs microtubule end recognition

Editor rating: 8 / 10

Patrizia Lavia –– The issue of how mitotic microtubules interact with the kinetochores of chromosomes is highly relevant to chromosome segregation, and hence to the generation of genetically balanced cells. Errors in the process are, on the contrary, detrimental to genetic stability. Microtubules, though being stably attached to chromosomes, must retain their dynamic ability throughout mitosis in order to move and pull the chromosomes towards the poles. MCAK is a kinesin that has an important role, is absolutely required in the process, yet its mechanism of action is known only in part. Here the authors expand our mechanistic understanding of this kinesin and propose an interesting model for its function. Their revised version is well written and has a very clear, convincing discussion that an reach a broad audience in the field of control of chromosome segregation and genome stability.
PBxplore: a tool to analyze local protein structure and deformability with Protein Blocks

Editor rating: 9 / 10

Walter de Azevedo Jr. –– The authors report the development and application of a suite of tools, called PBxplore. This computational tool can be used to analyze the dynamics and deformability of protein structures using Protein Blocks (PBs). It is an interesting development for scientists interesting in molecular dynamics simulations of protein structures.

Discussing these articles

Ever wonder how many lionfish spawned the invasion in the Atlantic? Probably over 100! https://t.co/XHpPpH52ud

Profiling soil microbial communities with next-generation sequencing: the influence of DNA kit selection and technician technical expertise https://t.co/7Yb3oztKOm

244 days ago
Check our new paper about symbiont genotypes changes in coral juveniles under heat condition. https://t.co/GYSZWdSffo #coral_juveniles #ocean_warming #Symbiodinium #サンゴ #褐虫藻 https://t.co/pIzWYuixcv

RNAi based pesticides may not be as safe as they are marketed. Buyer beware @thePeerJ https://t.co/SuCsMepM9k #Biotechnology #Ecology #Entomology #Toxicology #Ecotoxicology

Epigenetic considerations in #aquaculture https://t.co/4ciRD90hq6 via @thePeerJ https://t.co/jrBq9km9sR

252 days ago
Hannah's paper is published today. Just in time for her lab meeting! @thePeerJ https://t.co/9AT7wV5H0b #Biochemistry #Biophysics #MolecularBiology

My article has been published today in @thePeerJ https://t.co/jHwNBx4ZGb #Bioinformatics #ComputationalBiology #MolecularBiology

Discover Magazine: Dozens—Perhaps Even Hundreds—of Lionfish Likely Launched the Atlantic Invasion
http://blogs.discovermagazine.com/science-sushi/2017/12/27/dozens-perhaps-even-hundreds-of-lionfish-likely-launched-the-atlantic-invasion/