Biochemistry, Biophysics and Molecular Biology

Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding

Editor rating: 8 / 10

Jerson Silva –– This work has the novelty to provide a detailed investigation of structure – thermodynamics relationship of the protein recognition process.
Differential gene expression during early development in recently evolved and sympatric Arctic charr morphs

Editor rating: 7 / 10

Marc Robinson-Rechavi –– This study allows to link natural variation in morphology with genetic divergence in expression patterns, thus helping link ecology to molecular genomics.
Complex versus simple models: ion-channel cardiac toxicity prediction

Editor rating: 8 / 10

Heiko Enderling –– This article discusses the contributions of quantitative models in predicting biology, and makes an important point about the balance of simplicity/complexity/accuracy/usefulness of biophysical models. If simple models capture biological complexity, the use of more detailed models must be properly justified.
Development of an RNA interference (RNAi) gene knockdown protocol in the anaerobic gut fungus Pecoramyces ruminantium strain C1A

Editor rating: 8 / 10

Alexandra Lusser –– The article describes the development of a new method in this field that should facilitate future research in this area.
Tissue material properties and computational modelling of the human tibiofemoral joint: a critical review

Editor rating: 7 / 10

Jun Pang –– It is a very interesting literature review.
Eukaryotes in the gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome

Editor rating: 7 / 10

Shih-Pin Chen –– This study provides more evidences supporting the possible association of gut eukaryotic composition with inflammation in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Lipid raft localization of TLR2 and its co-receptors is independent of membrane lipid composition

Editor rating: 8 / 10

Ayyalusamy Ramamoorthy –– The findings on the membrane domain localization is important and useful.
Small-scale screening of anticancer drugs acting specifically on neural stem/progenitor cells derived from human-induced pluripotent stem cells using a time-course cytotoxicity test

Editor rating: 7 / 10

Elena González-Burgos –– Novelty
Exosomal microRNA remodels the tumor microenvironment

Editor rating: 8 / 10

Maria Cristina Albertini –– Exosomal microRNAs are becoming interesting comunication mechanisms during pathogenesis.
Heightened visual attention does not affect inner ear function as measured by otoacoustic emissions

Editor rating: 7 / 10

Jafri Abdullah –– Fundamental correlation between visual and otoacoustic physiology.

Discussing these articles

Differential gene expression during early development in recently evolved and sympatric Arctic charr morphs Good job @vonStadarhraun https://t.co/SKVXoWQ3Ix via @thePeerJ

new publication: https://t.co/MONo6omrX3 a comprehensive analysis on how a well-defined simple heuristic is as good (if not better) than complex mathematical models, used by FDA and bloated pharma companies, in ion-channel safety pharmacology #mathbiology

Our article has been published today in @thePeerJ https://t.co/xsVSirvY3c. Well done Abby Peters - another PhD output! @livuniAgeing @livunieng #Bioengineering #Biotechnology #ComputationalBiology

205 days ago
#Exosomal #microRNA remodels the #tumor microenvironment. https://t.co/sVcjLC25lk https://t.co/4fcM1emOTS

"Eukaryotes in the gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome": https://t.co/5UKkoepUbU