Biochemistry, Biophysics and Molecular Biology

Development and validation of statistical shape models of the primary functional bone segments of the foot
Tim Doyle –– Statistical shape models are increasing in their use. As such, research like this is needed.
A simple and efficient cloning system for CRISPR/Cas9-mediated genome editing in rice
Kun Lu –– CRISPR-Cas9 based genome editing has become the method of choice for the rapid generation of transgenic plants. We hope that the fast and efficient cloning system the authors presented could facilitate genetic engineering in plants.
Flavonoids from Epimedium pubescens: extraction and mechanism, antioxidant capacity and effects on CAT and GSH-Px of Drosophila melanogaster
Chin Ping Tan –– This paper highlights work related to ultrasound extraction of flavonoids from Epimedium pubescens and subsequent evaluation on antioxidant properties and effect of the extract on fruit flies.
DNA methylation profiling in recurrent miscarriage
Vladimir Uversky –– This study can be useful for better understanding of the molecular basis of recurrent miscarriage
Prognostic factors and survival outcomes according to tumor subtype in patients with breast cancer lung metastases
Walter de Azevedo Jr. –– In this paper, the authors described a study focused on prognosis of breast cancer lung metastases. The manuscript brings analysis of data obtained from 6516 patients with lung metastatic breast cancer. Their results gave new insight into the incidence, prognostic assessment, and risk stratification of breast cancer with lung metastases, enriching the study of the epidemiology of this occurrence.
Icaritin, an inhibitor of beta-site amyloid cleaving enzyme-1, inhibits secretion of amyloid precursor protein in APP-PS1-HEK293 cells by impeding the amyloidogenic pathway
Paul Tulkens –– This paper shows that an aprenylflavonoid derivative from Epimedium brevicornum Maxim may have neuroprotective effects. Icaritin, an inhibitor of beta-site amyloid cleaving enzyme-1, inhibits indeed the secretion of amyloid precursor protein in APP-PS1-HEK293 cells by impeding the amyloidogenic pathway. This effect, however, is only studied in vitro, calling for further studies demonstrating its potential in vivo.
In vitro histomorphometric comparison of dental pulp tissue in different teeth
Abhiram Maddi –– This article very nicely describes the methodology for isolation of dental pulp stem cells using histological analysis.
Design and preliminary application of affinity peptide based on the structure of the porcine circovirus type II Capsid (PCV2 Cap)
Omar Gonzalez-Ortega –– Improvements in protein purification are always relevant. The in silico procedure followed is interesting.
Propofol inhibits stromatoxin-1-sensitive voltage-dependent K+ channels in pancreatic β-cells and enhances insulin secretion
Vladimir Uversky –– The manuscript reports important data and definitely will have a noticeable impact.
Concentrated ambient PM2.5 exposure affects mice sperm quality and testosterone biosynthesis
Najat Saliba –– PM2.5 is one of the major causes of morbidity and mortality and more evidence on the effect of PM2.5 on health can strengthen the calls for an urgent need to control air pollution worldwide.
Biochemistry, Biophysics and Molecular Biology

Section discussions

Data mining methods such as CRISP-DM are widely used to give structure to #Analytics initiatives. But they are rarely used as-is. We just published the results of a Multivocal Literature Review showing how these methods are usually adapted and why #crispdm

New #marine #nematode species Chromadorina tangaroa from the hull of a research vessel is described in PEERJ

Studying the impacts of wheat spatial position and phenology on cereal aphid abundance @MeravSeifan

An article I handled as editor has been published today @thePeerJ #AnimalBehavior #Ecology #EcosystemScience

Identifying multiple collagen gene family members as potential gastric cancer biomarkers using integrated bioinformatics analysis @thePeerJ

Herbicide applications increase greenhouse gas emissions of alfalfa pasture in the inland arid region of northwest China @thePeerJ