Biochemistry, Biophysics and Molecular Biology

Research on the measurement of intracranial hemorrhage in rabbits by a parallel-plate capacitor
Jafri Abdullah –– More portable star trek like scanning equipment are important for screening blood clots in the brains are needed
Identification and molecular characterization of mutations in nucleocapsid phosphoprotein of SARS-CoV-2
Timothy Newsome –– Understanding the significance of SARS-CoV-2 genomic changes is key to an effective response in the current pandemic. This new research identified the N-protein as a mutational hotspot, with potential implications to a number of aspects of virus replication.
Cinnamtannin B1 attenuates rosacea-like signs via inhibition of pro-inflammatory cytokine production and down-regulation of the MAPK pathway
Consolato Sergi –– Cinnamtannin B1 is a tannin found in Cinnamomum verum and has been found to have pharmacological effects in treating type 2 diabetes mellitus and insulin resistance. This article brilliantly targets the attenuation of rosacea-like symptoms by investigating the MAPK pathway.
Improved plaque assay for human coronaviruses 229E and OC43
Rogerio Sotelo-Mundo –– The method proposed by Bracci et al. provides a practical assay to evaluate antiviral compounds using a cellular assay that does not rely on reverse transcriptase-PCR. The use of milder human coronavirus strains HCoV-229E and OC43 in BSL-2 biosafety conditions will permit the evaluation of potential drugs in an in vitro antiviral assay.
Combination of circulating miR-145-5p/miR-191-5p as biomarker for breast cancer detection
Barbara Bartolini –– Breast cancer still causes many deaths, and it is clear that early detection can play a huge role in modulating a positive outcome. Screening tests are available but every improvement in finding biomarkers easy to be identified with non-invasive screening will be well accepted by patients clinicians. In addition, the cntribution of non coding RNA to cancr biology is currently a topic of major interest.
In vitro and in vivo hypolipidemic properties of the aqueous extract of Spirulina platensis, cultivated in colored flasks under artificial illumination
Thiago Parente –– It provides a relevant contribution to the production of hypolipidemic compounds from cultivated Spirulina algae.
Investigation of acute-phase proteins and cytokines response in goats with contagious caprine pleuropneumonia with special reference to their diagnostic accuracy
Korakot Nganvongpanit –– Acute-phase proteins had valued diagnostic potentialities in response to infection. This study had evaluated the diagnostic accuracy of selected acute-phase proteins and proinflammatory cytokines in goats with contagious caprine pleuropneumonia. The result of this study endorses the significance of selected acute-phase proteins and proinflammatory cytokines as additional screening diagnostic parameters for naturally occurring contagious caprine pleuropneumonia in goats.
Differentially expressed serum proteins in children with or without asthma as determined using isobaric tags for relative and absolute quantitation proteomics
Abhiram Maddi –– This article is probably one of the very few to examine differentially expressed serum proteins in asthma patients. It may provide significant information related to diagnosis and therapy.
Identification and functional characterization of SlDronc in Spodoptera littoralis
Gianluca Tettamanti –– This study expands knowledge on the apoptotic pathway in Lepidoptera.
In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts
Jara Pérez-Jiménez –– The authors performed a proper characterization of the product, with evaluation of in vitro biological activities. The results they obtained may be the basis for future studies.
Biochemistry, Biophysics and Molecular Biology

Section discussions

3 days ago
My first first-author paper is finally published!

4 days ago
Link to the paper on @thePeerJ :

Prediction of DNA binding proteins using local features and long-term dependencies with primary sequences based on deep learning @thePeerJ

Centromere protein N may be a novel malignant prognostic biomarker for hepatocellular carcinoma @thePeerJ

A Toll-like receptor identified in Gigantidas platifrons and its potential role in the immune recognition of endosymbiotic methane oxidation bacteria @thePeerJ