Biochemistry, Biophysics and Molecular Biology

A real-time PCR assay to accurately quantify polar bear DNA in fecal extracts
Xavier Pochon –– A valuable novel qPCR assay for accurate quantification of the amount of polar bear DNA in fecal extracts!
DeepBindPoc: a deep learning method to rank ligand binding pockets using molecular vector representation
Walter de Azevedo Jr. –– In this research paper, Zhang et al. report the development of a new computational tool to assess protein-ligand interaction using machine-learning techniques. This new approach can rank ligand-binding pockets using molecular vector representation. The predictive power of this new method has been determined using high-resolution crystallography structures of protein-ligand complexes. The authors demonstrated that their computational approach has a complementary advantage over the popular Fpocket score in many test cases.
Characterizing metabolic stress-induced phenotypes of Synechocystis PCC6803 with Raman spectroscopy
Siouxsie Wiles –– New tools to study bacterial response to stresses/environmental changes.
Icariin affects cell cycle progression and proliferation of human retinal pigment epithelial cells via enhancing expression of H19
Diego Wilke –– Natural products are a prolific source if medicines highly relevant to treat countless human diseases. In this paper, icaridin effects suitable to treat retinopathy is depicted.
In vitro anticancer activity of methanolic extract of Granulocystopsis sp., a microalgae from an oligotrophic oasis in the Chihuahuan desert
Vladimir Uversky –– This work describes anticancer activity of the extract of microalgae from the Cuatro Cienegas Basin (CCB), an oasis in the Chihuahuan desert in Mexico and suggests that it represents a promising alternative against cancer.
Transcriptome profiling of kenaf (Hibiscus cannabinus L.) under plumbic stress conditions implies the involvement of NAC transcription factors regulating reactive oxygen species-dependent programmed cell death
Kun Lu –– An interesting heavy metal adaption mechanism in plants.
Suppression of osteogenic differentiation and mitochondrial function change in human periodontal ligament stem cells by melatonin at physiological levels
Dunxian Tan –– This study has obvious clinical implication related to the potential association of melatonin levels and bone formation. This association has not been clarified previously.
Endoplasmic reticulum stress and the protein degradation system in ophthalmic diseases
Gwyn Gould –– ER stress and the UPR play important roles in the pathology of many diseases, including ophthalmic conditions. This review addresses the role of the ER, autophagy and ubiquitin in these diseases with an examination of the role of ER stress and UPR as a particular focus.
Tight DNA-protein complexes isolated from barley seedlings are rich in potential guanine quadruplex sequences
Ruslan Kalendar –– The nucleotide composition and its complexity is not random and has different evolutionary and functional features. The study of such sites is important and demonstrates the multiple effects of GC-rich sequences enriched in guanine quadruplexes interaction with proteins.
Homeoprotein OTX1 and OTX2 involvement in rat myenteric neuron adaptation after DNBS-induced colitis
Jerson Silva –– The study evidences that colitis up-regulates OTX1 and OTX2 in myenteric plexus, with a potential participation in the inflammatory-related myenteric ganglia remodeling processes.
Biochemistry, Biophysics and Molecular Biology

Section discussions

100 visitors to my 'Effects of temperature on metabolic scaling in black carp' article published in #OpenAccess journal @thePeerJ

My article has been published today in @thePeerJ #Biodiversity #ConservationBiology #Ecology #Forestry

A new chapter in our jellyfish benthic stages search published in @PeerJ! This paper by @ju_vbtv, @VanderveerHenkW and me documents first in situ find of polyps and podocysts of 2 common North Sea jellyfish species. Found hiding inside bivalve shells. 1/11

Кто проживает в горах океана? Astrolirus patricki – семирукие морские звезды, обнаруженные на подводных горах Тихого океана в компании губок, на которые иногда даже по трое забираются. Новый вид назван, конечно же, в честь Патрика, дружочка Спанч Боба.

Exact integer linear programming solvers outperform simulated annealing for solving conservation planning problems @thePeerJ