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Section Highlights View all Biochemistry, Biophysics and Molecular Biology articles

Chigno/CG11180 and SUMO are Chinmo-interacting proteins with a role in Drosophila testes somatic support cells
"This paper identifies new players in Drosphila testes stem cell differentiation by identifying Chimno interacting partners."
Judith Yanowitz, Handling Editor
Bimetallic nanoparticles and biochar produced by Adansonia Digitata shell and their effect against tomato pathogenic fungi
"The manuscript addresses a relevant issue, the search for new compounds with antifungal activities."
Héctor Mora-Montes, Handling Editor
Molecular cloning and characterization of farnesyl diphosphate synthase from Rosa rugosa Thunb associated with salinity stress
Mahmood-ur- Rahman, Handling Editor
Cyy-287, a novel pyrimidine-2,4-diamine derivative, efficiently mitigates inflammatory responses, fibrosis, and lipid synthesis in obesity-induced cardiac and hepatic dysfunction
"The discussed work highlights the global concern of obesity as a public health epidemic, emphasizing its association with chronic inflammation and related diseases. The research focuses on a novel compound, Cyy-287, reporting on its inhibitory effect on high-fat diet-induced inflammation and tissue damage in mice. The study delves into the molecular mechanisms, revealing that Cyy-287 acts by inhibiting NF-κB and MAPK signaling pathways, activating AMPK signaling, and suppressing liver lipid synthesis. The findings suggest that Cyy-287 has therapeutic potential for mitigating obesity-induced cardiac and hepatic damage. The limitations are acknowledged, and future studies are proposed to deepen the understanding of Cyy-287's mechanisms and effects. The work is significant for researchers and clinicians interested in developing treatments for obesity-related complications."
Sonia Oliveira, Handling Editor
A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of Momordica cymbalaria Hook F
"Herbal medicines remain a relevant field that not only provides functional phytopharmaceutical molecules for the pharmaceutical industry but also in other industries such as cosmetics or food. The challenges with standardization and quality control can be overcome when comprehensive reviews are performed on a plant source."
Sonia Oliveira, Handling Editor
Retrospective study and implementation of a low-cost LAMP-turbidimetric assay for screening α0-thalassemia (SEA deletion): preventing and controlling Hb Bart’s hydrops fetalis syndrome in Thailand
"Shows the application of a fast real time molecular test kit in a clinical setting"
Efe Sezgin, Handling Editor
Proteomic detection of COX-2 pathway-related factors in patients with adenomyosis
Srinivas Sistla, Handling Editor
Advances in macrophage and T cell metabolic reprogramming and immunotherapy in the tumor microenvironment
"The manuscript is an updated literature revision of the tumor microenvironment and its influence on cellular immune effectors. It also covers clinical trials of therapies to control cancer."
Héctor Mora-Montes, Handling Editor
Ticagrelor alleviates pyroptosis of myocardial ischemia reperfusion-induced acute lung injury in rats: a preliminary study
"The study addresses the high prevalence of pulmonary infection in patients with acute myocardial infarction undergoing per-cutaneous coronary intervention (PCI) and aims to elucidate the potential mechanisms involved. Specifically, the research investigates the role of myocardial ischemia-reperfusion injury (MIRI) in inducing acute lung injury (ALI) related to pulmonary infection and inflammation. The study explores the novel concept of pyroptosis, a form of programmed cell death, as a mediator of ALI in the lungs during MIRI. Ticagrelor, an antiplatelet drug with known effects on ALI and pyroptosis-associated proteins, is examined for its potential to alleviate MIRI-induced ALI in a rat model. Results indicate that MIRI induces ALI, evidenced by increased lung pathology markers, wet-to-dry ratio, and expression of pyroptosis-related proteins. Notably, pre-treatment with ticagrelor mitigates these effects, suggesting a potential therapeutic role for ticagrelor in attenuating MIRI-induced pulmonary complications by suppressing pyroptosis in the lungs. The findings contribute valuable insights into the complex interplay between cardiovascular events, pulmonary complications, and potential pharmacological interventions in this context."
Sonia Oliveira, Handling Editor
Chemical and spectroscopic characterization of (Artemisinin/Querctin/ Zinc) novel mixed ligand complex with assessment of its potent high antiviral activity against SARS-CoV-2 and antioxidant capacity against toxicity induced by acrylamide in male rats
"Based on this research, the novel Zn/Artemisinin/Quercetin mixed ligand complex holds great promise as a multifunctional therapeutic agent. It demonstrates potent antiviral activity against SARS-CoV-2, which is highly relevant in the context of the COVID-19 pandemic. Furthermore, the complex offers significant protective effects against Acy-induced toxicity and oxidative stress, highlighting its potential as an antioxidant agent. This study presents a comprehensive evaluation of the complex's antiviral and protective properties, providing valuable insights for the development of novel treatments targeting viral infections and oxidative stress-related disorders."
Sonia Oliveira, Handling Editor
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