Biochemistry, Biophysics and Molecular Biology

Editors' Picks

Development of a single-chain fragment variable fused-mutant HALT-1 recombinant immunotoxin against G12V mutated KRAS colorectal cancer cells
Maria Cristina Albertini –– Important results have been found with advances in colorectal cancerogenesis.
Effect of leaf position and days post-infiltration on transient expression of colorectal cancer vaccine candidate proteins GA733-Fc and GA733-FcK in Nicotiana benthamiana plant
Abhiram Maddi –– Production of vaccines in plants may be an important approach in the future as we deal with the current pandemic.
The effect of carbon monoxide on meiotic maturation of porcine oocytes
Judith Yanowitz –– The impact of carbon monoxide on oocyte maturation has the potential to change in vitro culturing methodology to increase oocyte quality.
Preparation and characterization of gelatin-polysaccharide composite hydrogels for tissue engineering
Omar Gonzalez-Ortega –– The potential final application is attractive. Despite this, there is still work to be done to "optimize" the composite gel.
Exploring the occurrence of thioflavin-T-positive insulin amyloid aggregation intermediates
Eugene Permyakov –– Any new information on insulin properties is of importance for medicine.
Effective ribosomal RNA depletion for single-cell total RNA-seq by scDASH
Joseph Gillespie –– Loi et al. describe a novel approach for performing rRNA depletion in single cell sequencing experiments that facilitates detection of non-polyadenylated and partially degraded RNAs.
Research on the measurement of intracranial hemorrhage in rabbits by a parallel-plate capacitor
Jafri Abdullah –– More portable star trek like scanning equipment are important for screening blood clots in the brains are needed
Identification and molecular characterization of mutations in nucleocapsid phosphoprotein of SARS-CoV-2
Timothy Newsome –– Understanding the significance of SARS-CoV-2 genomic changes is key to an effective response in the current pandemic. This new research identified the N-protein as a mutational hotspot, with potential implications to a number of aspects of virus replication.
Cinnamtannin B1 attenuates rosacea-like signs via inhibition of pro-inflammatory cytokine production and down-regulation of the MAPK pathway
Consolato Sergi –– Cinnamtannin B1 is a tannin found in Cinnamomum verum and has been found to have pharmacological effects in treating type 2 diabetes mellitus and insulin resistance. This article brilliantly targets the attenuation of rosacea-like symptoms by investigating the MAPK pathway.
Improved plaque assay for human coronaviruses 229E and OC43
Rogerio Sotelo-Mundo –– The method proposed by Bracci et al. provides a practical assay to evaluate antiviral compounds using a cellular assay that does not rely on reverse transcriptase-PCR. The use of milder human coronavirus strains HCoV-229E and OC43 in BSL-2 biosafety conditions will permit the evaluation of potential drugs in an in vitro antiviral assay.
Biochemistry, Biophysics and Molecular Biology

Section discussions

#Bioinformatics analysis for the identification of differentially expressed genes and related signaling pathways in H. pylori-CagA transfected gastric cancer cells Read the full @PeerJLife article #Biochemistry #Bioinformatics #CellBiology #Microbiology

New @PeerJLife article examines the identification and characterization of #melon circular RNAs involved in powdery mildew responses through comparative transcriptome analysis Read the full article #AgriculturalScience #Bioinformatics

Stability of hepatitis B virus pregenomic RNA in plasma specimens under various temperatures and storage conditions @thePeerJ

A #NewSpecies Meiogyne oligocarpa (#Annonaceae), named from Yunnan, China published in @PeerJLife #Biodiversity #MolecularBiology #PlantScience #Taxonomy