Preprints (not yet peer-reviewed)

The immune checkpoint plays an important role in keeping immune cells in check for protecting tissues and organs from attack by the body’s own immune system. Similar concepts also apply in how cancer cells managed to fool immune cells through the surface display...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Computational Biology"]
doi:10.7287/peerj.preprints.27670v1

Therapeutic nucleic acids provide versatile treatment options for hereditary or acquired diseases. Ionic complexes with basic polymers are frequently used to facilitate nucleic acid’s transport to intracellular target sites. Usually, these polyplexes are prepared...

["Bioengineering","Biophysics","Biotechnology"]
doi:10.7287/peerj.preprints.27669v1
30 downloads
42 views

Background: Colorectal cancer (CRC) is a malignant tumor particularly common in developing countries. In this study, we used Weighted Gene Co-Expression Network Analysis (WGCNA) of chip data and screened hub genes in CRC to find the gene modules specifically correlated...

["Bioinformatics","Oncology","Pathology"]
doi:10.7287/peerj.preprints.27667v1
18 downloads
51 views

Cluster differentiation gene (CD14) is a family of monocyte differentiating genes that works in conjunction with lipopolysaccharide binding protein (LBP), forming a complex with TLR4 or LY96 to mediate innate immune response to pathogens. In this report, we used...

["Computational Biology","Evolutionary Studies","Genomics","Immunology"]
doi:10.7287/peerj.preprints.27668v1
42 downloads
53 views

Natural history museums are unique spaces for interdisciplinary research and for educational innovation. Through extensive exhibits and public programming and by hosting rich communities of amateurs, students, and researchers at all stages of their careers, they...

["Biodiversity","Ecology","Evolutionary Studies","Science Policy","Biosphere Interactions"]
doi:10.7287/peerj.preprints.27666v1
41 downloads
51 views

Background: Nontyphoidal Salmonella spp. transmitted through various routes are a major concern of food poisoning due to the consumption of contaminated food. Objective: To establish a molecular-based protocol for simple and rapid subtyping of Salmonella isolates...

["Microbiology","Molecular Biology","Epidemiology"]
doi:10.7287/peerj.preprints.27664v1
33 downloads
38 views

Background. In recent years, the scientific community encouraged the use of raw data graphs to improve the reliability and transparency of the results presented in papers. However, methods to visualize raw data are limited to one variable per graph and/or only...

["Bioinformatics","Science and Medical Education","Statistics","Data Science"]
doi:10.7287/peerj.preprints.27665v1
440 downloads
791 views

The metabolic processes of cells and chemical processes in the environment are fundamentally intertwined and have evolved in concert over billions of years. Here I argue that intrinsic properties of cellular metabolism imposed central constraints on the historical...

["Ecology","Evolutionary Studies","Microbiology","Biosphere Interactions","Biogeochemistry"]
doi:10.7287/peerj.preprints.27269v2
78 downloads
195 views

Different species of echinoids and bivalves are suffering infectious diseases as the effect of ocean warming. In Sardinia (Western Mediterranean Sea) the keystone sea urchin species Paracentrotus lividus (Lamarck 1816) is widely appreciated as edible resource....

["Ecology","Marine Biology","Parasitology","Zoology"]
doi:10.7287/peerj.preprints.27644v2
39 downloads
51 views

Using remote sensing data of sea surface temperature (SST), chlorophyll-a (Chl-a) together with catch data, the pelagic hotspots of Skipjack tuna (SKPJ) were identified. MODIS/Aqua satellite data and the fish catch data were obtained during 2002-2016 period. Empirical...

["Ecology","Marine Biology","Statistics","Food, Water and Energy Nexus","Biological Oceanography"]
doi:10.7287/peerj.preprints.27663v1
28 downloads
45 views

North Indian Ocean region around India and Sri Lanka is a complex and rich coastal ecosystem undergoing various seasonal and inter-annual changes and various pressures. Hence the objective of this study was to assess the scales of coupling between chlorophyll-a...

["Ecology","Ecosystem Science","Statistics","Climate Change Biology","Biological Oceanography"]
doi:10.7287/peerj.preprints.27662v1
843 downloads
1,082 views

Milkweeds (Asclepias) are used in wide-ranging studies including floral development, pollination biology, plant-insect interactions and co-evolution, secondary metabolite chemistry, and rapid diversification. We present a transcriptome and draft nuclear genome...

["Evolutionary Studies","Genomics","Plant Science"]
doi:10.7287/peerj.preprints.26488v2
42 downloads
61 views

In urban ecosystems, woody vegetation communities and the ecosystem functions and habitat they provide are largely controlled by humans. These communities are assembled during development, landscaping, and maintenance processes according to decisions made by human...

["Conservation Biology","Coupled Natural and Human Systems","Environmental Impacts"]
doi:10.7287/peerj.preprints.27661v1
31 downloads
60 views

Cancer cells exhibit myriad characteristics that differentiate them from normal cells; for example, cell surface markers, morphology, cellular metabolism, gene expression, and migratory tendency. Amongst the characteristics, cancer cell metabolism is the least...

["Biochemistry","Bioinformatics","Biotechnology","Cell Biology","Computational Biology"]
doi:10.7287/peerj.preprints.27660v1
26 downloads
48 views

Although much remains unknown about this once-obscure structure, the lateral habenula is receiving increasing attention as a component of the circuitry of many conditions including mood disorders, anxiety disorders, pain disorders, substance use disorders, psychosis...

["Neuroscience","Cognitive Disorders","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.27659v1
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