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neuroscience

Synaptic exocytosis requires the assembly of syntaxin 1A and SNAP-25 on the plasma membrane and synaptobrevin 2 (VAMP2) on the vesicular membrane to bridge the two opposite membranes. It is believed that the three SNARE proteins assemble in steps along the dynamic...

["Biochemistry","Biophysics","Microbiology","Neuroscience"]
doi:10.7717/peerj.1065

The cannabinoid receptor type 1 (CB1) antagonist rimonabant has been used as treatment for obesity. In addition, anti-proliferative effects on mitogen-activated leukocytes have been demonstrated in vitro. We have previously shown that rimonabant (SR141716A) induces...

["Cell Biology","Neuroscience","Hematology","Immunology","Metabolic Sciences"]
doi:10.7717/peerj.1056
25 downloads
236 views

There has been initial evidence to support the Dysexecutive Luck hypothesis, which proposes that beliefs in being unlucky are associated with deficits in executive functioning (Maltby et al., 2013). The present study tested the Dysexecutive Luck hypothesis by examining...

["Neuroscience","Psychiatry and Psychology"]
doi:10.7717/peerj.1007
17 downloads
132 views

Asymmetries in the response to visual patterns in the upper and lower visual fields (above and below the centre of gaze) have been associated with ecological factors relating to the structure of typical visual environments. Here, we investigated whether the content...

["Neuroscience","Psychiatry and Psychology"]
doi:10.7717/peerj.1038
36 downloads
314 views

When a good decision leads to a bad outcome, the experience of regret can bias subsequent choices: people are less likely to select the regret-producing alternative a second time, even when it is still objectively the best alternative (non-adaptive choice switching)....

["Neuroscience","Psychiatry and Psychology"]
doi:10.7717/peerj.1035
56 downloads
486 views

There is an increasing need to validate and collect data approximating brain size on individuals in the field to understand what evolutionary factors drive brain size variation within and across species. We investigated whether we could accurately estimate endocranial...

["Animal Behavior","Neuroscience","Zoology"]
doi:10.7717/peerj.1000
46 downloads
552 views

There is evidence to suggest that impulsivity is predicted by socioeconomic background, with people from more deprived backgrounds tending to be more impulsive, and by current mood, with poorer mood associated with greater impulsivity. However, impulsivity is not...

["Neuroscience","Psychiatry and Psychology"]
doi:10.7717/peerj.964
77 downloads
511 views

Previous research has shown that odorants consistently evoke associations with textures and their tactile properties like smoothness and roughness. Also, it has been observed that olfaction can modulate tactile perception. We therefore hypothesized that tactile...

["Neuroscience","Psychiatry and Psychology"]
doi:10.7717/peerj.955
63 downloads
343 views

Parkinson disease (PD) is the most common movement disorder, characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra. While the cause of this disease is largely unknown, a rare autosomal dominant familial form of PD is caused...

["Neuroscience","Neurology"]
doi:10.7717/peerj.945
45 downloads
398 views

Bone pain is a common and severe symptom in cancer patients. The present study employed a mouse model of leukemia bone pain by injection K562 cells into tibia of mouse to evaluate the analgesic effects of lappacontine. Our results showed that the lappaconitine...

["Animal Behavior","Neuroscience","Pharmacology"]
doi:10.7717/peerj.936
60 downloads
528 views

We examined abnormalities in physiological responses to emotional stimuli associated with long-term chronic alcoholism. Skin conductance responses (SCR) and heart rate (HR) responses were measured in 32 abstinent alcoholic (ALC) and 30 healthy nonalcoholic (NC)...

["Neuroscience","Anatomy and Physiology","Psychiatry and Psychology"]
doi:10.7717/peerj.941
64 downloads
422 views

Background. Datasets consisting of synthetic neural data generated with quantifiable and controlled parameters are a valuable asset in the process of testing and validating directed functional connectivity metrics. Considering the recent debate in the neuroimaging...

["Biophysics","Neuroscience","Computational Science"]
doi:10.7717/peerj.923
49 downloads
305 views

Although modern baleen whales (Mysticeti) retain a functional olfactory system that includes olfactory bulbs, cranial nerve I and olfactory receptor genes, their olfactory capabilities have been reduced to a great degree. This reduction likely occurred as a selective...

["Evolutionary Studies","Neuroscience","Zoology","Anatomy and Physiology","Histology"]
doi:10.7717/peerj.897
1 citation
74 downloads
470 views

Background. Previous work has demonstrated that a commercial gaming electroencephalography (EEG) system, Emotiv EPOC, can be adjusted to provide valid auditory event-related potentials (ERPs) in adults that are comparable to ERPs recorded by a research-grade EEG...

["Neuroscience","Psychiatry and Psychology"]
doi:10.7717/peerj.907
353 downloads
6,729 views

Autonomous Sensory Meridian Response (ASMR) is a previously unstudied sensory phenomenon, in which individuals experience a tingling, static-like sensation across the scalp, back of the neck and at times further areas in response to specific triggering audio and...

["Neuroscience","Neurology","Psychiatry and Psychology"]
doi:10.7717/peerj.851

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