Peer-reviewed Articles

Total of 2,208 results
Add subject filter

While there have been enormous advances in our understanding of the genetic drivers and molecular pathways involved in cancer in recent decades, there also remain key areas of dispute with respect to fundamental theories of cancer. The accumulation of vast new...

["Computational Biology","Oncology","Computational Science"]
doi:10.7717/peerj.2176

Background. Glufosfamide (GLU) is a glucose conjugate of ifosfamide in which isophosphoramide mustard is glycosidically linked to the β-D-glucose molecule. Based on GLU structure, it is considered a targeted chemotherapy with fewer side effects. The main objective...

["Cell Biology","Oncology","Pharmacology"]
doi:10.7717/peerj.2168
1 download
1 view

The failure of traditional interventions to block and cure HIV infections has led to novel proposals that involve treating infections with therapeutic viruses–infectious viruses that specifically inhibit HIV propagation in the host. Early efforts in evaluating...

["Biotechnology","Mathematical Biology","Microbiology","Virology","Infectious Diseases"]
doi:10.7717/peerj.2166
1 download
1 view

An important trend in the early evolution of mammals was the shift from a sprawling stance, whereby the legs are held in a more abducted position, to a parasagittal one, in which the legs extend more downward. After that transition, many mammals shifted from a...

["Evolutionary Studies","Zoology"]
doi:10.7717/peerj.2131
11 downloads
115 views

The baculovirus expression vector system (BEVS) has been widely used to produce a large number of recombinant proteins, and is becoming one of the most powerful, robust, and cost-effective systems for the production of eukaryotic proteins. Nevertheless, as in any...

["Biotechnology","Molecular Biology","Virology"]
doi:10.7717/peerj.2183
10 downloads
87 views

Background. Little is known about the clinical impact of new root canal preparation systems in general dental practice under routine care conditions. Therefore, we compared hand instrumentation (H) with Reciproc (R) (VDW, Munich, Germany) preparation. The outcomes...

["Dentistry","Public Health"]
doi:10.7717/peerj.2182
8 downloads
190 views

Supertree methods combine a set of phylogenetic trees into a single supertree. Similar to supermatrix methods, these methods provide a way to reconstruct larger parts of the Tree of Life, potentially evading the computational complexity of phylogenetic inference...

["Bioinformatics","Computational Biology","Evolutionary Studies","Genetics","Taxonomy"]
doi:10.7717/peerj.2172
10 downloads
151 views

Static properties of leaves with parallel venation, with particular emphasis on the genus EpipactisZinn, 1757 (Orchidaceae, Neottieae) have been modelled with coupled quasi-parallel elastic “beams.” The non-linear theory of strongly bended beams have been employed....

["Agricultural Science","Biophysics","Mathematical Biology","Plant Science"]
doi:10.7717/peerj.2165
14 downloads
151 views

Hereditary breast and ovarian cancer syndrome, caused by a germline pathogenic variant in the BRCA1 or BRCA2 (BRCA1/2) genes, is characterized by an increased risk for breast, ovarian, pancreatic and other cancers. Identification of those who have a BRCA1/2 mutation...

["Genetics","Genomics","Oncology","Women\u2019s Health"]
doi:10.7717/peerj.2162
4 downloads
71 views

Insects under different stimuli from the environment modify behavioural responses due to changes in the sensitivity of neurons at the peripheral and/or at the central level of the nervous system. This phenomenon is called neuronal plasticity, and sensory adaptation...

["Animal Behavior","Entomology","Toxicology"]
doi:10.7717/peerj.2150
12 downloads
80 views

Members of the Caliciviridae family of positive sense RNA viruses cause a wide range of diseases in both humans and animals. The detailed characterization of the calicivirus life cycle had been hampered due to the lack of robust cell culture systems and experimental...

["Molecular Biology","Virology"]
doi:10.7717/peerj.2134
7 downloads
94 views

Species-rich genus Primula L. is a typical plant group with which to understand genetic variance between species in different levels of relationships. Chloroplast genome sequences are used to be the information resource for quantifying this difference and reconstructing...

["Genomics","Plant Science"]
doi:10.7717/peerj.2101
5 downloads
67 views

Ultrasound (US), Thermo-sonication (TS) and High Pressure Homogenization (HPH) were studied as tools to inactivate the spores of Penicillium spp. and Mucor spp. inoculated in distilled water. For US, the power ranged from 40% to 100%, pulse from 2 to 10 s, and...

["Biotechnology","Food Science and Technology"]
doi:10.7717/peerj.2020
20 downloads
125 views

Edge preserving filters aim to simplify the representation of images (e.g., by reducing noise or eliminating irrelevant detail) while preserving their most significant edges. These filters are typically nonlinear and locally smooth the image structure while minimizing...

["Algorithms and Analysis of Algorithms","Computer Vision"]
doi:10.7717/peerj-cs.72
22 downloads
228 views

The acoustic space in a given environment is filled with footprints arising from three processes: biophony, geophony and anthrophony. Bioacoustic research using passive acoustic sensors can result in thousands of recordings. An important component of processing...

["Bioinformatics","Computational Biology"]
doi:10.7717/peerj-cs.70

Top subject areas - Articles

Top subject areas - People

View all subject areas