Preprints (not yet peer-reviewed)

62 downloads
29 views

The “reproducibility crisis” has been a highly visible source of scientific controversy and dispute. Here, I propose and review several avenues for identifying and prioritizing research studies for the purpose of targeted validation. Of the various proposals discussed,...

["Bioinformatics","Evidence Based Medicine","Health Policy","Translational Medicine","Science Policy"]
doi:10.7287/peerj.preprints.2830v1
25 downloads
79 views

Background. Osteoarthritis is the leading cause of chronic joint pain, causing important productivity and economic losses. It is believed that peripheral and centralized sensitization play a role in the creation and maintenance of a chronic painful state. Different...

["Anaesthesiology and Pain Management","Pharmacology","Rheumatology","Translational Medicine"]
doi:10.7287/peerj.preprints.2704v1
11 downloads
130 views

Context. The statistical analysis is an important part of the process of assessing the quality of randomized controlled trials, unfortunately it tends to be underestimated or even omitted by editors, in this sense, scales that cover this gap becomes necessary....

["Translational Medicine","Statistics"]
doi:10.7287/peerj.preprints.2609v1
437 downloads
365 views

“Open access” has become a central theme of journal reform in academic publishing. In this article, I examine the consequences of an important technological loophole in which publishers can claim to be adhering to the principles of open access by releasing articles...

["Bioinformatics","Evidence Based Medicine","Health Policy","Translational Medicine","Science Policy"]
doi:10.7287/peerj.preprints.2566v1
99 downloads
120 views

Developing new endpoints for mobility is an important strategic aim for many groups both in industry and academia and the focus of a growing field. Bringing those novel endpoints to health authority acceptance for clinical decision making will require a concerted...

["Clinical Trials","Evidence Based Medicine","Translational Medicine","Computational Science"]
doi:10.7287/peerj.preprints.2546v1
40 downloads
179 views

Motivation Ferroportin (Fpn) is a membrane protein belonging to the Major Facilitator Superfamily of transporters. It is the only vertebrate iron exporter known so far. Several Fpn mutations lead to the so-called ‘ferroportin disease’ or type 4 haemochromatosis,...

["Biochemistry","Bioinformatics","Cell Biology","Computational Biology","Translational Medicine"]
doi:10.7287/peerj.preprints.2149v1
51 downloads
155 views

Objective: The aim of this study was to use the Animals in Research: Reporting In Vivo Experiments (ARRIVE) guidelines to evaluate the quality of reporting of recent gastric cancer animal experiments. Materials and Methods: A literature search of studies was performed...

["Veterinary Medicine","Gastroenterology and Hepatology","Oncology","Translational Medicine","Statistics"]
doi:10.7287/peerj.preprints.2049v1
151 downloads
1,377 views

Background: Digital medicine and smartphone-enabled health technologies provide a novel source of human health and human biology data. However, in part due to its intricacies, few methods have been established to analyze and interpret data in this domain. We previously...

["Evidence Based Medicine","Translational Medicine","Science and Medical Education","Human-Computer Interaction","Computational Science"]
doi:10.7287/peerj.preprints.1911v1
147 downloads
267 views

Recent studies have shown that International medical graduates (IMG) comprise a substantial and increasingly larger share of the medical workforce, internationally. IMGs wishing to work in English-speaking countries face many challenges. And overcoming such challenges...

["Translational Medicine","Science and Medical Education","Computational Science"]
doi:10.7287/peerj.preprints.1711v2
303 downloads
299 views

Purpose. Type 2 diabetes is the leading cause of end stage renal disease in the United States. Atherosclerotic renal artery stenosis is commonly observed in diabetic patients and impacts the rate of renal and cardiovascular disease progression. We hypothesized...

["Cardiology","Diabetes and Endocrinology","Nephrology","Pathology","Translational Medicine"]
doi:10.7287/peerj.preprints.1323v2
222 downloads
308 views

Cell communication is central to the integration of cell function required for the development and homeostasis of multicellular animals. Proteins are an important currency of cell communication, acting locally (auto-, juxta-, or paracrine) or systemically (endocrine)....

["Biochemistry","Drugs and Devices","Surgery and Surgical Specialties","Translational Medicine"]
doi:10.7287/peerj.preprints.1378v1
67 downloads
144 views

The GCTF-PRO seeks to examine the extent gastric cancer patients are tapping into new information particularly outside of conventional healthcare disclosures. Its significance is in assessing dimensions of QOL paradigms that frame statistical power using predictive...

["Evidence Based Medicine","Health Policy","Translational Medicine","Statistics","Palliative Care"]
doi:10.7287/peerj.preprints.1344v1
93 downloads
260 views

Kisspeptin receptor (KISS1R) agonists with increased half-life and similar efficacy to kisspeptin in vitro may provide beneficial applications in breeding management of many species. However, many of these agonists have not been tested in vivo. These studies were...

["Veterinary Medicine","Anatomy and Physiology","Translational Medicine"]
doi:10.7287/peerj.preprints.912v1
82 downloads
416 views

We report a method to cause cell death by remotely heating microparticles by induction heating, this technique could be used to remove vascular deposits and thrombosis. In this preliminary work, we used micrometer size spherical (ferromagnetic) particles and (pure)...

["Bioengineering","Biophysics","Drugs and Devices","Translational Medicine"]
doi:10.7287/peerj.preprints.815v1
1,123 downloads
513 views

Despite the increasing availability of chemicals, the number of New Drug Approvals (NDA) from the Food and Drug Administration (FDA) remains unchanged. The number of chemical structures available online via web-based open source applications will reach the symbolic...

["Bioinformatics","Public Health","Translational Medicine","Science Policy","Statistics"]
doi:10.7287/peerj.preprints.813v1
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