Preprints (not yet peer-reviewed)

43 downloads
78 views

CodonGenie, freely available from http://codon.synbiochem.co.uk, is a simple web application for designing ambiguous codons to support protein mutagenesis applications. Ambiguous codons are derived from specific heterogeneous nucleotide mixtures, which create sequence...

["Bioengineering","Bioinformatics","Biotechnology","Computational Biology","Synthetic Biology"]
doi:10.7287/peerj.preprints.2797v1
70 downloads
155 views

Indoles represent a structural element in a myriad of natural products and biologically active molecules. Of special importance are 2,3-disubstituted indoles. Thus, a number of methods for their synthesis have been described. However, these are often hampered by...

["Biochemistry","Computational Biology","Synthetic Biology"]
doi:10.7287/peerj.preprints.1842v1
244 downloads
428 views

In the early days of the human genome project (HGP), during the late 1980s and early 1990s, there was skepticism that the genome project would produce biologically meaningful information. The reality is that bioinformatics has allowed us to extract far more biology...

["Bioinformatics","Biotechnology","Computational Biology","Genomics","Synthetic Biology"]
doi:10.7287/peerj.preprints.1501v1
48 downloads
245 views

Two Component Systems and Phosphorelays (TCS/PR) are environmental signal transduction cascades in prokaryotes and, less frequently, in eukaryotes. The internal domain organization of proteins and the topology of TCS/PR cascades play an important role in shaping...

["Bioinformatics","Computational Biology","Mathematical Biology","Synthetic Biology"]
doi:10.7287/peerj.preprints.1267v1
159 downloads
269 views

Bacterial populations transition between growing and non-growing phases, based on nutrient availability and stress conditions. The hallmark of a growing state is anabolism, including DNA replication and cell division. In contrast, bacteria in a growth-arrested...

["Bioinformatics","Computational Biology","Microbiology","Synthetic Biology"]
doi:10.7287/peerj.preprints.866v1
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