Preprints (not yet peer-reviewed)

47 downloads
197 views

Sigmoidal and double-sigmoidal dynamics are commonly observed in many areas of biology. Here we present sicegar, an R package for the automated fitting and classification of sigmoidal and double-sigmodial data. The package categorizes data into one of three categories,...

["Bioinformatics","Computational Biology","Mathematical Biology","Statistics","Data Science"]
doi:10.7287/peerj.preprints.3116v1
28 downloads
388 views

Pedigrees, though straightforward and versatile, lack the ability to tell us information about many individuals. Though numerical systems have been developed, there is currently no system to quantify the probability of a pedigree following certain inheritance systems....

["Bioinformatics","Genetics","Mathematical Biology","Statistics"]
doi:10.7287/peerj.preprints.2871v5
42 downloads
202 views

We studied the effect of linearization on the repeatability of the Tofts and reference region models (RRM) for Dynamic Contrast-Enhanced MRI (DCE MRI). We compared the repeatabilities of these two linearized models, the standard non-linear version, and semi-quantitative...

["Mathematical Biology","Radiology and Medical Imaging","Statistics"]
doi:10.7287/peerj.preprints.2824v1
38 downloads
400 views

Marker gene sequencing of microbial communities has generated big datasets of microbial relative abundances varying across environmental conditions, sample sites and treatments. These data often come with putative phylogenies, providing unique opportunities to...

["Computational Biology","Ecology","Mathematical Biology","Microbiology","Statistics"]
doi:10.7287/peerj.preprints.2685v1
110 downloads
730 views

Wildlife collision data are ubiquitous, though challenging for making ecological inference due to typically irreducible uncertainty relating to the sampling process. We illustrate a new approach that is useful for generating inference from predator data arising...

["Conservation Biology","Ecology","Mathematical Biology","Statistics"]
doi:10.7287/peerj.preprints.2572v1
139 downloads
302 views

‘Big Data’ and a surge in quantitative methodologies increasingly urge bioresearchers to train and improve their mathematical and computational skills. In response to this challenge the Biotechnology and Biological Sciences Research Council in the United Kingdom...

["Computational Biology","Mathematical Biology","Science and Medical Education","Statistics","Computational Science"]
doi:10.7287/peerj.preprints.2523v1
46 downloads
344 views

Complex physiological dynamics have been argued to be a signature of healthy physiological function. Here we test whether the complexity of metabolic rate fluctuations in small endotherms decreases with lower environmental temperatures. To do so we examine the...

["Computational Biology","Ecology","Mathematical Biology","Statistics"]
doi:10.7287/peerj.preprints.2404v1
72 downloads
221 views

Estimation of natural selection on protein-coding sequences is a key comparative genomics approach for de novo prediction of lineage specific adaptations. Selective pressure is measured on a per-gene basis by comparing the rate of non-synonymous substitutions to...

["Bioinformatics","Computational Biology","Evolutionary Studies","Mathematical Biology","Statistics"]
doi:10.7287/peerj.preprints.2218v1
46 downloads
191 views

Background. In the early and late stages of cell reprogramming to induced pluripotent stem cells (iPSCs) ectopic expression of Oct4, Sox2, Klf4 and Myc (OSKM) aroused two peaks of transcriptional and epigenetic change respectively. However, it was relatively quiet...

["Bioinformatics","Cell Biology","Mathematical Biology","Molecular Biology","Statistics"]
doi:10.7287/peerj.preprints.1991v1
321 downloads
285 views

Bayesian statistics, in contrast to classical statistics, uses probability to represent uncertainty about the state of knowledge. Bayesian statistics has often been associated with the idea that knowledge is subjective and that a probability distribution represents...

["Conservation Biology","Ecology","Mathematical Biology","Science Policy","Statistics"]
doi:10.7287/peerj.preprints.1755v1
234 downloads
152 views

Length of hospital stay (LOS) is of primary importance in health services research because it is directly related to health care management and cost of health care. In some epidemiological settings the actual length of stay is not directly observed but it is known...

["Mathematical Biology","Epidemiology","Infectious Diseases","Public Health","Statistics"]
doi:10.7287/peerj.preprints.1663v1
46 downloads
184 views

The conservation and management of wild populations and ecosystems almost always involves making decisions in the face of uncertainty and risk. The application of science to the ecological decision-making process was something that the late Professor Daniel Goodman...

["Conservation Biology","Ecology","Mathematical Biology","Science Policy","Statistics"]
doi:10.7287/peerj.preprints.1583v1
610 downloads
608 views

Mathematical models are frequently used to assess the impact of control interventions for Chlamydia trachomatis and other sexually transmitted infections (STIs). Modeling approaches that stratify the population by the number of sex partners often assume the transmission...

["Computational Biology","Mathematical Biology","Epidemiology","Infectious Diseases","Statistics"]
doi:10.7287/peerj.preprints.940v2
104 downloads
244 views

The conserved nature of sleep in Drosophila has allowed the fruit fly to emerge in the last decade as a powerful model organism in which to study sleep. Recent sleep studies in Drosophila have focused on the discovery and characterization of hyposomnolent mutants....

["Animal Behavior","Entomology","Mathematical Biology","Statistics"]
doi:10.7287/peerj.preprints.1408v1
169 downloads
432 views

In biological mass spectrometry, crude instrumental data need to be converted into meaningful theoretical models. Several data processing and data evaluation steps are required to come to the final results. These operations are often difficult to reproduce, because...

["Bioinformatics","Biophysics","Computational Biology","Mathematical Biology","Statistics"]
doi:10.7287/peerj.preprints.1359v1
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