Preprints (not yet peer-reviewed)

84 downloads
151 views

The mutational processes responsible for the somatic mutations observed in tumor samples can significantly vary not only between tumor types but also among the individual cancers within a tumor class. Mutational processes can be represented by so called “mutational...

["Bioinformatics","Computational Biology","Genomics","Oncology"]
doi:10.7287/peerj.preprints.3257v1
43 downloads
220 views

We previously demonstrated how CITED1 knockdown in melanoma cells had the capacity to perturb expression of a significant number of genes that comprised MITF and several of its known transcriptional targets. This manifest as a switch from a more invasive to a more...

["Cell Biology","Genomics","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.3146v1
402 downloads
3,302 views

OncoRank adopts a method for finding recurrent miRNA-target interactions to find genes with consistent relationships to patient survival across cancers. Genes are first ranked in each cancer by their Cox coefficients, and these ranks are then combined by applying...

["Bioinformatics","Genomics","Oncology"]
doi:10.7287/peerj.preprints.2574v1
283 downloads
592 views

Identification of appropriate reference genes (RGs) is critical to accurate data interpretation in quantitative real-time PCR (qPCR) experiments. In this study, we have utilised next generation RNA-sequencing (RNA-seq) to analyse the transcriptome of a panel of...

["Genomics","Molecular Biology","Dermatology","Oncology","Medical Genetics"]
doi:10.7287/peerj.preprints.2331v1
434 downloads
288 views

Hereditary breast and ovarian cancer syndrome, caused by a germline deleterious variant in the BRCA1 or BRCA2 genes, is characterized by an increased risk for breast, ovarian, pancreatic and other cancers. Identification of those who have a BRCA1/2 mutation is...

["Genetics","Genomics","Oncology","Women's Health"]
doi:10.7287/peerj.preprints.1463v1
397 downloads
1,529 views

There is a need for a genomic theoretical framework which would explain the increasingly vast and discreet genomic data in the context of phenomena observed in cell. The search for a genomic explanation to functional networks of cancer metasignature genes lead...

["Bioinformatics","Cell Biology","Evolutionary Studies","Genomics","Oncology"]
doi:10.7287/peerj.preprints.126v3
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