Preprints (not yet peer-reviewed)

34 downloads
245 views

Previous studies have used the zebrafish to investigate the biology of lens crystallin proteins and their roles in development and disease. However, little is known about zebrafish α-crystallin promoter function, how it compares to that of mammals, or whether mammalian...

["Developmental Biology","Molecular Biology","Neuroscience","Ophthalmology"]
doi:10.7287/peerj.preprints.2889v1
199 downloads
934 views

Synapsida, the clade including therapsids and thus also mammals, is one of the two major branches of amniotes. Organismal design, with modularity as a concept, offers insights into the evolution of therapsids, a group that experienced profound anatomical transformations...

["Developmental Biology","Evolutionary Studies","Neuroscience","Paleontology","Anatomy and Physiology"]
doi:10.7287/peerj.preprints.2313v2
33 downloads
161 views

Background. Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in the development and function of multiple organs and organ systems, including the central nervous system (CNS). FGF signaling via FGFR1, one of the three FGFRs expressed in...

["Cell Biology","Developmental Biology","Neuroscience"]
doi:10.7287/peerj.preprints.2729v1
42 downloads
182 views

As space flight becomes more accessible in the future, humans will be exposed to gravity conditions other than our 1G environment on Earth. Changes in physiology and anatomy in altered gravity conditions have long been observed, especially the loss of muscle mass...

["Developmental Biology","Genetics","Neuroscience"]
doi:10.7287/peerj.preprints.2363v1
66 downloads
234 views

Fibroblast growth factors (FGFs) and their receptors (FGFRs) have numerous functions in the developing and adult CNS. For example, the FGFR1 receptor is important for proliferation of radial glial cells in the cortex and hippocampus, oligodendrocyte proliferation...

["Cell Biology","Developmental Biology","Neuroscience","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.2343v1
96 downloads
819 views

Systematic studies of micronutrients during brain formation are hindered by restrictions to animal models and adult post-mortem tissues. Recently, advances in stem cell biology have enabled recapitulation of the early stages of human telencephalon development....

["Developmental Biology","Neuroscience"]
doi:10.7287/peerj.preprints.2126v1
1,073 downloads
4,451 views

Zika virus (ZIKV) has been associated with microcephaly and other brain abnormalities; however, the molecular and cellular consequences of Zika virus circulating in Brazil to the human brain development have not been studied yet. Here we describe alterations in...

["Cell Biology","Developmental Biology","Microbiology","Molecular Biology","Neuroscience"]
doi:10.7287/peerj.preprints.2033v1
3,475 downloads
13,795 views

Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased dramatically in Brazil; however, causality between the widespread epidemic and malformations in fetal brains has not been confirmed. Here, we examine the effects of ZIKV infection...

["Cell Biology","Developmental Biology","Neuroscience"]
doi:10.7287/peerj.preprints.1817v3
102 downloads
364 views

Neonatal eye loss leads to an expansion of the primary somatosensory cortex (S1) in rodents. In blind rats, S1 expansion results from the predisplacement of S1 formation during the first three days of life, a process modulated by epigenetic factors. Some of these...

["Developmental Biology","Neuroscience"]
doi:10.7287/peerj.preprints.1782v1
92 downloads
202 views

Background: A macrogene is defined here as a gene on which successive mutations incrementing a repeat count produces successive punctuated evolutionary events in species that are homogeneous for it. The set of repeat count on the asp (abnormal spindle) family of...

["Developmental Biology","Neuroscience"]
doi:10.7287/peerj.preprints.1237v1
625 downloads
354 views

One of the great mysteries of the brain, which has puzzled all-time students of brain form and function is the contralateral organization of the forebrain, and the crossings of its major afferent and efferent connections. As a novel explanation, two recent studies...

["Developmental Biology","Neuroscience","Zoology"]
doi:10.7287/peerj.preprints.432v2
304 downloads
354 views

Aetiologies of developmental dyslexia often assume a deficit in auditory processing may be causally entailed in the specific learning disorder. The purpose of this study is to compare a number of assumed auditory features that are supposed to evidence the account...

["Biophysics","Developmental Biology","Neuroscience","Cognitive Disorders","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.341v1
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