Preprints (not yet peer-reviewed)

22 downloads
162 views

It is now widely accepted that oligomers consisting of Aβ peptide are the cytotoxic species contributing mostly to the development of Alzheimer’s disease. Aβ peptide production results from the specific proteolytic processing of the amyloid precursor protein (APP)....

["Biophysics","Biotechnology","Cell Biology","Molecular Biology","Neuroscience"]
doi:10.7287/peerj.preprints.2804v1
35 downloads
168 views

Background. Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in the development and function of multiple organs and organ systems, including the central nervous system (CNS). FGF signaling via FGFR1, one of the three FGFRs expressed in...

["Cell Biology","Developmental Biology","Neuroscience"]
doi:10.7287/peerj.preprints.2729v1
40 downloads
251 views

Background. Bax Inhibitor-1 (BI-1), an integral transmembrane protein, acts as a suppressor of Bax-induced apoptosis through regulation of endoplasmic reticulum (ER) stress-induced cell death. The gene is highly conserved being found in a diverse range of organisms...

["Cell Biology","Genetics","Neuroscience"]
doi:10.7287/peerj.preprints.2548v1
68 downloads
244 views

Fibroblast growth factors (FGFs) and their receptors (FGFRs) have numerous functions in the developing and adult CNS. For example, the FGFR1 receptor is important for proliferation of radial glial cells in the cortex and hippocampus, oligodendrocyte proliferation...

["Cell Biology","Developmental Biology","Neuroscience","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.2343v1
1,107 downloads
4,491 views

Zika virus (ZIKV) has been associated with microcephaly and other brain abnormalities; however, the molecular and cellular consequences of Zika virus circulating in Brazil to the human brain development have not been studied yet. Here we describe alterations in...

["Cell Biology","Developmental Biology","Microbiology","Molecular Biology","Neuroscience"]
doi:10.7287/peerj.preprints.2033v1
676 downloads
2,012 views

Harmine is a β-carboline alkaloid present at highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation. It has been shown that Ayahuasca presents...

["Cell Biology","Neuroscience"]
doi:10.7287/peerj.preprints.1957v1
3,499 downloads
13,844 views

Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased dramatically in Brazil; however, causality between the widespread epidemic and malformations in fetal brains has not been confirmed. Here, we examine the effects of ZIKV infection...

["Cell Biology","Developmental Biology","Neuroscience"]
doi:10.7287/peerj.preprints.1817v3
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