Preprints (not yet peer-reviewed)

26 downloads
162 views

Small interference RNA has been widely used to suppress gene expression. Three different short-hairpin RNAs (shRNAs) against dopamine D1 receptor (Drd1), driven by mouse U6 promoter in self-complementary AAV8 vector (scAAV8), were used to silence mouse striatal...

["Neuroscience","Neurology","Pathology"]
doi:10.7287/peerj.preprints.3117v1
56 downloads
175 views

A scientific theory or hypothesis is presented, in which mineral particles may play a pivotal role in the prion disease transmissible spongiform encephalopathy (TSE), and possibly also in other protein-misfolding diseases. Montmorillonite clay (Mte) and other minerals...

["Cell Biology","Molecular Biology","Infectious Diseases","Neurology"]
doi:10.7287/peerj.preprints.2982v1
125 downloads
640 views

The involvement of the right and left hemispheres in mediating language functions has been measured in a variety of ways over the centuries since the relative dominance of the left hemisphere was first known. Functional magnetic resonance imaging (fMRI) presents...

["Neuroscience","Neurology","Psychiatry and Psychology","Radiology and Medical Imaging"]
doi:10.7287/peerj.preprints.2962v2
35 downloads
168 views

The search for a universal definition of death is a relatively new objective in human history, framed by complex biological, technological, and socio-political factors. While it is widely understood that “life” and “death” describe inverse states of being, what...

["Health Policy","Neurology","Ethical Issues","Legal Issues"]
doi:10.7287/peerj.preprints.2890v1
50 downloads
184 views

Walking velocity is an important control variable in gait disorders due to sensory or cerebellar disfunction. Non-preferred walking speeds are closely linked to a higher risk of falls. A compensation strategy of patients to avoid these speed sectors can be assumed....

["Bioinformatics","Anatomy and Physiology","Neurology"]
doi:10.7287/peerj.preprints.2545v1
47 downloads
261 views

The study of subjective, first-person experience is a topic with both philosophical and practical implications. In this article, I discuss the value of collecting a critical mass of prose or verbal descriptions of introspectively determined, subjective effects...

["Toxicology","Evidence Based Medicine","Neurology","Pharmacology","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.2424v1
657 downloads
381 views

Background: Astrocytomas and oligodendrogliomas are two types of primary Central nervous system (CNS) tumors. Because of the cytoarchitectural variability and lacking of accurate differential diagnosis biomarkers, distinguishing between these neoplasms remains...

["Neuroscience","Neurology"]
doi:10.7287/peerj.preprints.2179v1
65 downloads
274 views

The autonomy of individuals is linked to the achievement of instrumental activities of daily living that require complex behavior. In elderly, the assessment of autonomy is usually based on questionnaires that have strong subjective constraints. Considering this...

["Neurology","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.2111v1
87 downloads
483 views

The objective of this pilot study was to evaluate the feasibility of Flash Visual Evoked Potentials (FVEPs) testing in birds of prey in a clinical setting and to describe the protocol and the baseline data for normal vision in this species. FVEP recordings were...

["Neuroscience","Veterinary Medicine","Zoology","Neurology"]
doi:10.7287/peerj.preprints.1875v2
253 downloads
320 views

Mild traumatic brain injury typically involves temporary impairment of neurological function. Previous studies used the water pressure or rotational injury for designing the device to make a rat mild traumatic brain injury model. The objective of this study was...

["Neuroscience","Neurology"]
doi:10.7287/peerj.preprints.2037v1
337 downloads
708 views

Parkinson's disease (PD) is one of the most common neurodegenerative disorders, yet the etiology of the majority of its cases remains unknown. In this article, relevant published evidence is interpreted and integrated into a comprehensive hypothesis on the nature,...

["Cell Biology","Neurology"]
doi:10.7287/peerj.preprints.1314v4
134 downloads
560 views

Language Impairment (LI) is a developmental disorder that mainly manifests impaired language learning and processing. Evidence, largely from English-speaking population studies, has shown that children with LI compared to typically developing (TD) children have...

["Cognitive Disorders","Neurology","Pediatrics","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.1675v1
410 downloads
399 views

The present contribution reports direct numerical simulations of pulsatile flow through a 75% eccentric stenosis using the Lattice Boltzmann Method (LBM). The stenosis was previously studied by Varghese, Frankel, and Fischer in a benchmark computation, and the...

["Computational Biology","Neurology","Computational Science"]
doi:10.7287/peerj.preprints.1548v3
248 downloads
858 views

Background: Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulatory technique that has shown encouraging results regarding performance improvement of normal subjects in tests of executive functions. Moreover, when applied repeatedly in...

["Clinical Trials","Neurology","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.1610v1
272 downloads
266 views

Objectives: Previous studies have consistently shown increased rates of childhood adversity in chronic fatigue syndrome (CFS). However, such aetiopathogenic studies of CFS are potentially confounded by co-morbidity and misdiagnosis particularly with depression....

["Neurology"]
doi:10.7287/peerj.preprints.1571v1
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