Preprints (not yet peer-reviewed)

40 downloads
98 views

Here we shall apply the approach presented in the paper Dynamics of resource allocation in biological systems in considering resource allocation in cancer cell metabolism, specifically, aerobic glycolysis (Warburg effect). Aerobic glycolysis, the metabolic phenomenon...

["Biochemistry","Cell Biology","Mathematical Biology","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.2533v1
107 downloads
228 views

The late detection of non-genotoxic carcinogens in the drug development process can delay drug candidates for unmet medical needs from reaching the market despite considerable investments in their development. To enable faster, safer, and less expensive development...

["Bioinformatics","Computational Biology","Molecular Biology","Oncology","Pharmacology"]
doi:10.7287/peerj.preprints.2393v1
112 downloads
365 views

Identification of appropriate reference genes (RGs) is critical to accurate data interpretation in quantitative real-time PCR (qPCR) experiments. In this study, we have utilised next generation RNA-sequencing (RNA-seq) to analyse the transcriptome of a panel of...

["Genomics","Molecular Biology","Dermatology","Oncology","Medical Genetics"]
doi:10.7287/peerj.preprints.2331v1
27 downloads
119 views

Background. Mitotic arrest deficient 2 (Mad2) is a key component of spindle assembly checkpoint and overexpressed in human lung cancers, but the mechanism of the deregulation of Mad2 in lung cancer is largely unknown. We aim to investigate the regulation of Mad2...

["Cell Biology","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.2298v1
25 downloads
151 views

Motivation Neuroblastoma (NB) is the most common solid pediatric tumor, deriving from ganglionic lineage precursors of the sympathetic nervous system. Half of the patients with high-risk NB die despite treatment and more accurate outcome prediction models are needed...

["Bioinformatics","Molecular Biology","Oncology","Pediatrics"]
doi:10.7287/peerj.preprints.2263v1
30 downloads
124 views

Cross-contamination of human and animal cell lines is a frequent event. For this reason, the results obtained with the same cell lines by different research groups are often not fully comparable, this leading to main reproducibility issues. The short tandem repeat...

["Bioinformatics","Cell Biology","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.2194v1
175 downloads
309 views

Background: Colorectal cancer (CRC) is one of the commonest cancers in Malaysia and majority of the patients will present with advanced disease at diagnosis particularly in cases of proximal CRCs. Little is known about the relationship between the genetic landscape...

["Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.2109v1
70 downloads
150 views

Synthetic analogs of 1alpha,25-dihydroxycholecalciferol [1alpha,25-(OH)2D3] and 1alpha,25-dihydroxyergocalciferol [1alpha,25-(OH)2D2] have long been considered as key regulators of calcium and phosphate homeostasis. These analogs have been recently investigated...

["Biochemistry","Molecular Biology","Oncology","Pharmacology","Science and Medical Education"]
doi:10.7287/peerj.preprints.1653v1
180 downloads
451 views

Background: Papillary thyroid carcinoma (PTC) is the commonest thyroid malignancy originating from the follicle cells in the thyroid. Despite a good overall prognosis, certain high-risk cases as in those with lymph node metastasis (LNM) have progressive disease...

["Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.1535v1
166 downloads
374 views

Background: The somatic mutation theory as the origin of cancer (carcinogenesis) was born some 100 years ago, when Theodor Boveri 1914 suggested that a combination of chromosomal defects may result in cancer. This was followed by Karl-Heinrich Bauer in 1928 suggesting...

["Cell Biology","Genetics","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.1024v1
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