Preprints (not yet peer-reviewed)

18 downloads
87 views

Background. The current study aims to explore the effects of advanced glycation end products (AGEs) on the microRNA (miRNA) expression profile in kidney tissues in a murine diabetic nephropathy (DN) model, and to investigate the possible underlying mechanisms....

["Genomics","Molecular Biology","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.3026v1
77 downloads
306 views

Whole genome sequencing is opening the door to novel insights into the population structure and evolutionary history of poorly known species. In organisms with large genomes, which includes most amphibians, whole-genome sequencing is excessively challenging and...

["Bioinformatics","Evolutionary Studies","Genomics","Molecular Biology","Zoology"]
doi:10.7287/peerj.preprints.2980v1
33 downloads
206 views

Trichoplax adhaerens, the only known species of Placozoa is likely to be closely related to an early metazoan that preceded branching of Cnidaria and Bilateria. This animal species is surprisingly well adapted to free life in the World Ocean inhabiting tidal costal...

["Evolutionary Studies","Genomics","Molecular Biology","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.2945v1
66 downloads
168 views

In the past decades, novel pharmaceutical compounds have been produced by a wide diverse groups of marine bacteria. These marine bacteria are potential reservoirs for antimicrobial products. In this study, we investigated 40 soil samples collected from the Great...

["Biodiversity","Genomics","Marine Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.2910v1
27 downloads
163 views

American trypanosomiasis is a chronic and endemic disease, which affects millions of people. Trypanosoma cruzi, its causative agent, has a life cycle that involves complex morphological and functional transitions, as well as a variety of environmental conditions....

["Biochemistry","Genomics","Molecular Biology","Parasitology","Infectious Diseases"]
doi:10.7287/peerj.preprints.2782v1
72 downloads
383 views

Introduction 2nd generation sequencing or better known as next-generation sequencing (NGS) represents a cutting-edge technology in life sciences and current foundation for unravelling nucleotide sequences. Since advent of first platforms in 2005 the number of different...

["Bioinformatics","Biotechnology","Genomics","Molecular Biology"]
doi:10.7287/peerj.preprints.2771v1
93 downloads
293 views

Introduction Next Generation Sequencing (NGS) platforms have radically changed the field of genomics and are routinely applied to a variety of functional genomics problems. Although NGS has markedly accelerated multiple areas of genomics research it is a massively...

["Bioinformatics","Genomics","Molecular Biology","Computational Science"]
doi:10.7287/peerj.preprints.2752v1
22 downloads
98 views

Structure informs function, and this may be the evolutionary reason why alternative splicing, which is capable of generating different variants of the same protein, arise. But, given the energetic cost of generating different splice variants for testing their capability...

["Biochemistry","Bioinformatics","Genomics","Molecular Biology","Anatomy and Physiology"]
doi:10.7287/peerj.preprints.2717v1
49 downloads
327 views

Chlamydia suis is a swine pathogen that also causes zoonotic infections. Many strains contain a tet(C) cassette conferring tetracycline resistance originally acquired by horizontal gene transfer from a Gram-negative donor. As we and others have described the capacity...

["Cell Biology","Genomics","Microbiology","Molecular Biology","Infectious Diseases"]
doi:10.7287/peerj.preprints.2489v1
328 downloads
1,402 views

The high cost of library preparation remains a major obstacle to sequencing large numbers of individual genomes. Illumina’s proprietary tagmentation technology allows for rapid and easy preparation of sequencing libraries, but remains prohibitively expensive for...

["Bioinformatics","Genomics","Molecular Biology"]
doi:10.7287/peerj.preprints.2475v1
55 downloads
231 views

microRNAs are small, non-coding RNAs involved in post-transcriptional gene regulation. Since the dysregulation of only a few miRNAs can affect many biological pathways, miRNAs are thought to play a key role in cancer development and can be used as biomarkers for...

["Bioinformatics","Genomics","Molecular Biology"]
doi:10.7287/peerj.preprints.2423v1
20 downloads
238 views

Background: Reference genes serve an important role as an endogenous control/standard for data normalisation in gene expression studies. Although reference genes have recently been suggested for marsupials, independent analysis of reference genes on different immune...

["Genomics","Molecular Biology"]
doi:10.7287/peerj.preprints.2422v1
419 downloads
462 views

Circular RNAs (circRNAs) belong to a recently re-discovered species of RNA that emerge during RNA maturation through a process called back-splicing. A downstream 5’ splice site is linked to an upstream 3’ splice site to form a circular transcript instead of a canonical...

["Bioinformatics","Computational Biology","Genomics","Molecular Biology"]
doi:10.7287/peerj.preprints.2418v1
171 downloads
451 views

Identification of appropriate reference genes (RGs) is critical to accurate data interpretation in quantitative real-time PCR (qPCR) experiments. In this study, we have utilised next generation RNA-sequencing (RNA-seq) to analyse the transcriptome of a panel of...

["Genomics","Molecular Biology","Dermatology","Oncology","Medical Genetics"]
doi:10.7287/peerj.preprints.2331v1
114 downloads
261 views

Advances in biodiversity genomic sequencing will increasingly depend on the availability of DNA samples—and their quantifiable metadata—preserved in large institutional biorepositories that are discoverable to the scientific community. Improvements in sequencing...

["Biodiversity","Bioinformatics","Genomics","Molecular Biology","Zoology"]
doi:10.7287/peerj.preprints.2202v1
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