Preprints (not yet peer-reviewed)

17 downloads
69 views

Drug discovery is a step-by-step process very important in biopharmaceutical field. We are interested in identifying new investigational drug-likes as potential inhibitors of determinate biological-therapeutic targets, trying to decrease the side effects and to...

["Bioinformatics","Computational Biology","Drugs and Devices"]
doi:10.7287/peerj.preprints.2639v1
64 downloads
155 views

Motivation. The human chymase (EC 3.4.21.39) is a hydrolase abundant in secretory granules of mast cells, responsible for the synthesis of angiotensin II from its precursor. Moreover, it is also responsible for the conversion of transforming growth factor-β (TGF-β)...

["Biochemistry","Bioinformatics","Computational Biology","Drugs and Devices"]
doi:10.7287/peerj.preprints.2185v1
293 downloads
296 views

Background: Glioblastoma multiforme (GBM) is a grade IV brain tumor that arises from star-shaped glial cells supporting neural cells called astrocytes. The survival of GBM patients remains poor despite many specific molecular targets that have been developed and...

["Biochemistry","Bioinformatics","Computational Biology","Drugs and Devices","Oncology"]
doi:10.7287/peerj.preprints.1582v3
78 downloads
237 views

The fight against the emergence of mutant influenza strains has led to the screening of an increasing number of compounds for inhibitory activity against influenza neuraminidase. This study explores the chemical space of neuraminidase inhibitors (NAIs), which provides...

["Bioinformatics","Computational Biology","Drugs and Devices","Computational Science"]
doi:10.7287/peerj.preprints.1554v2
117 downloads
311 views

Aromatase, which is a rate-limiting enzyme that catalyzes the conversion of androgen to estrogen, plays an essential role in the development of estrogen-dependent breast cancer. Side effects due to aromatase inhibitors (AIs) necessitate the pursuit of novel inhibitor...

["Bioinformatics","Computational Biology","Drugs and Devices","Pharmacology"]
doi:10.7287/peerj.preprints.1556v1
131 downloads
549 views

Current research and development approaches to drug discovery have become less fruitful and more costly. One alternative paradigm is that of drug repositioning. Many marketed examples of repositioned drugs have been identified through serendipitous or rational...

["Bioinformatics","Computational Biology","Drugs and Devices","Pharmacology","Computational Science"]
doi:10.7287/peerj.preprints.1427v1
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