Preprints (not yet peer-reviewed)

22 downloads
134 views

Introduction: Tissue engineering is being redesigned through promising studies that present great potential to create biomaterials capable of forming functional tissues. The cellular expansion and integration depends very much on the quality and adequacy of the...

["Bioengineering","Biotechnology","Cell Biology"]
doi:10.7287/peerj.preprints.3329v1
24 downloads
79 views

Scale transcends multiple levels of biological and physical organization, and is the critical factor that determines success of any scientific investigation. Specifically, the scale at which a question is posed plays a crucial role in influencing the type of experiments...

["Biochemistry","Bioengineering","Biophysics","Biotechnology","Cell Biology"]
doi:10.7287/peerj.preprints.3261v1
13 downloads
82 views

Microfluidic cell culture chambers have enabled the isolation, culture and growth of various species of microorganisms and human cells. However, based on elastomers such as poly(dimethyl siloxane) (PDMS), these culture devices are not readily amenable to imaging...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.3245v1
960 downloads
695 views

Divergence of treatment responses to chemotherapy exists across patients (often with unknown underlying mechanisms), with some patients exhibiting worsened outcome upon treatment. Genomic approaches (such as microarray profiling and whole genome sequencing) hold...

["Bioengineering","Bioinformatics","Cell Biology","Genomics","Histology"]
doi:10.7287/peerj.preprints.1049v6
371 downloads
680 views

Challenging disposal problems are associated with plastics use due to its poor biodegrability and emissions of hazardous chemicals during incineration. Poly-β-hydroxybutyric acids (PHB), a lipid based storage polymer in bacteria, is biodegradable, biorenewable...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.534v5
195 downloads
510 views

About a decade ago, I observed that as the cell growth rate increases, mRNAs coding for ribosomal proteins are transcriptionally induced to varying degrees. This observation puzzled me as it defied my expectation that faster growing cells meet their demands for...

["Biochemistry","Bioengineering","Cell Biology","Genomics"]
doi:10.7287/peerj.preprints.1504v1
77 downloads
362 views

This work follows as a response to a problem posed in a previous work (Jeff-Eke, 2015b). Here we propose and explore a probable solution to the posed problem of how well a cellular system can tolerate random changes to the frequency of osmolytes infused into an...

["Biochemistry","Bioengineering","Biophysics","Cell Biology","Computational Biology"]
doi:10.7287/peerj.preprints.1187v2
119 downloads
342 views

This is a companion to A Gauge model for analysis of Biological systems. Here we reconcile the gauge model with a “real” system, which in this case is a unicellular system. We address effects of infusion of free osmolytes into an intracellular space of interest,...

["Biochemistry","Bioengineering","Biophysics","Cell Biology","Mathematical Biology"]
doi:10.7287/peerj.preprints.1163v2
81 downloads
489 views

Meniscal tears are a common cause of stifle lameness in dogs. Use of autologous synoviocytes from the affected stifle is an attractive cell source for tissue engineering replacement fibrocartilage. However, the diseased state of these cells may impede in vitro...

["Bioengineering","Cell Biology","Veterinary Medicine","Orthopedics"]
doi:10.7287/peerj.preprints.475v1
146 downloads
491 views

Multiple cell types form specialized protein complexes, podosomes or invadopodia and collectively referred to as invadosomes, which are used by the cell to actively degrade the surrounding extracellular matrix. Due to their potential importance in both healthy...

["Bioengineering","Bioinformatics","Cell Biology","Computational Biology","Computational Science"]
doi:10.7287/peerj.preprints.320v1
1,248 downloads
471 views

Background: The thickness and composition of the surface liquid lining the human lungs are maintained by a balance between epithelial secretion and absorption of ions and water. An understanding of epithelial transport pathways and the factors that regulate them...

["Bioengineering","Biophysics","Cell Biology","Molecular Biology","Respiratory Medicine"]
doi:10.7287/peerj.preprints.256v1
181 downloads
550 views

In the clinical/microbiological laboratory there are currently several ways of separating specific cells from a fluid suspension. Conventionally cells can be separated based on size, density, electrical charge, light-scattering properties, and antigenic surface...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology"]
doi:10.7287/peerj.preprints.5
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