Preprints (not yet peer-reviewed)

41 downloads
258 views

Background. Osteoarthritis is the leading cause of chronic joint pain, causing important productivity and economic losses. It is believed that peripheral and centralized sensitization play a role in the creation and maintenance of a chronic painful state. Different...

["Anaesthesiology and Pain Management","Pharmacology","Rheumatology","Translational Medicine"]
doi:10.7287/peerj.preprints.2704v1
228 downloads
300 views

A 6-year-old female Shetland Sheepdog with a history of cardiorespiratory compromise during general anaesthesia was referred for ovariohysterectomy surgery. Clinical examination was unremarkable at presentation and physiologic parameters under general anaesthesia...

["Veterinary Medicine","Allergy and Clinical Immunology","Anaesthesiology and Pain Management","Emergency and Critical Care","Pharmacology"]
doi:10.7287/peerj.preprints.2275v1
84 downloads
242 views

Paclitaxel, a chemotherapeutic agent, causes neuropathic pain whose supraspinal pathophysiology is not fully understood. Dysregulation of sodium channel expression, studied mainly in the periphery and spinal cord level, contributes to the pathogenesis of neuropathic...

["Molecular Biology","Neuroscience","Anaesthesiology and Pain Management","Pharmacology"]
doi:10.7287/peerj.preprints.1936v1
84 downloads
253 views

Background. Medications are not exempt from adverse drug reactions (ADR) and how the physician perceives the risk of prescription drugs could influence their availability to report ADR and their prescription behavior. Methods. We assess the perception of risk and...

["Anaesthesiology and Pain Management","Pharmacology","Public Health","Science and Medical Education"]
doi:10.7287/peerj.preprints.1890v1
125 downloads
380 views

Valproate, an indirect γ-aminobutiric acid agonist has been successfully used in various painful conditions. Despite its frequent use, limited pre-clinical and clinical data exist about its analgesic effect. We tested valproate p.o. in increasing doses (10, 25,...

["Neuroscience","Anaesthesiology and Pain Management","Pharmacology"]
doi:10.7287/peerj.preprints.1613v1
472 downloads
512 views

Tramadol is used in both human and veterinary medicine to treat postoperative pain. The purpose of this study was to evaluate tramadol as a sole postoperative analgesic and to compare drug plasma concentration to clinical pain score. A high or low dose of tramadol...

["Anaesthesiology and Pain Management","Evidence Based Medicine","Pharmacology","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.1510v1
114 downloads
435 views

Spinal astrocyte activation contributes to the pathogenesis of paclitaxel-induced neuropathic pain (PINP) in animal models. We examined glial fibrillary acidic protein (GFAP; an astrocyte marker) immunoreactivity and gene expression of GFAP, glutamate transporters...

["Molecular Biology","Neuroscience","Anaesthesiology and Pain Management","Pharmacology"]
doi:10.7287/peerj.preprints.1246v2
452 downloads
384 views

Aim Pain associated poor sleep quality has been reported among opioid dependent patients on methadone maintenance therapy (MMT) but objective pain data are lacking. This study aimed to investigate the rate of objective pain sensitivity and the relationship between...

["Anaesthesiology and Pain Management","Drugs and Devices","Internal Medicine","Nursing","Pharmacology"]
doi:10.7287/peerj.preprints.615v1
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