Preprints (not yet peer-reviewed)

72 downloads
176 views

Currently the National Center of Biotechnology Information (NCBI) assigns individual taxonomy identifiers to each distinct influenza virus isolate submitted to GenBank. To support this practice, individual flu isolates must be manually added to the NCBI taxonomy...

["Bioinformatics","Computational Biology","Taxonomy","Virology","Science Policy"]
doi:10.7287/peerj.preprints.3428v1
32 downloads
124 views

The hemagglutinin subtypes from Influenza A can be divided into distinct lineages. This is important for tracing the evolutionary history of the gene. It allows regional lineages to be identified and studied. The process of lineage identification depends on phylogenetic...

["Bioinformatics","Virology","Computational Science"]
doi:10.7287/peerj.preprints.3396v1
35 downloads
140 views

The Rickettsiales-like prokaryote - Candidatus Xenohaliotis californiensis (Ca. Xc) – has decimated black abalone populations along the Pacific coast of North America. White abalone, – Haliotis sorenseni – are also susceptible and nearly extinct in the wild due...

["Aquaculture, Fisheries and Fish Science","Conservation Biology","Microbiology","Virology","Natural Resource Management"]
doi:10.7287/peerj.preprints.3351v1
39 downloads
302 views

Current research posits that all multicellular organisms live in symbioses with associated microorganisms and form so-called metaorganisms or holobionts. Cnidarian metaorganisms are of specific interest given that stony corals provide the foundation of the globally...

["Bioinformatics","Genomics","Virology","Biosphere Interactions"]
doi:10.7287/peerj.preprints.3343v1
28 downloads
251 views

Background. Enteroviruses are small non-enveloped viruses with (+) ssRNA genome with one open reading frame. Enterovirus protein 3C (or 3CD for some species) binds the replicative element oriL to initiate replication. The replication of enteroviruses features low...

["Evolutionary Studies","Genomics","Virology"]
doi:10.7287/peerj.preprints.3153v2
32 downloads
117 views

Lineage determination is an important part of the analysis of viral sequence data. Previously this has depended on phylogenetic analysis in order to identify distinct clades within the phylogenetic trees. This method is time consuming and dependent on a set of...

["Bioinformatics","Virology"]
doi:10.7287/peerj.preprints.3166v1
34 downloads
151 views

Recently, a novel phenomenon of horizontal gene transfer of helicase-encoding sequence from positive-stranded RNA viruses to LINE transposons in insect genomes was described. TRAS family transposons encoding an ORF2 protein, which comprised all typical functional...

["Entomology","Genomics","Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.3101v1
89 downloads
186 views

Background. The Ebola Virus Disease (EVD) is a highly infectious disease that has claimed over 25,000 cases in the past 50 years. While many past outbreaks of EVD resulted in relatively few incidents, the 2014 outbreak in West Africa was the most deadly occurrence...

["Virology","Epidemiology","Infectious Diseases","Statistics"]
doi:10.7287/peerj.preprints.3021v1
16 downloads
152 views

Live attenuated viral vaccines provide the most robust and longest lasting immune response. Yet designing them a priori to have reduced growth capacity and also to be robust to evolutionary reversion can be challenging. On the one hand, genome editing methods now...

["Evolutionary Studies","Virology"]
doi:10.7287/peerj.preprints.3001v1
41 downloads
256 views

Influenza A viruses cause an annual highly contagious respiratory disease in humans, and are responsible for periodic human pandemics that have high mortality rates. Pandemic influenza A viruses can result from reassortment of one or more gene segments between...

["Evolutionary Studies","Microbiology","Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.3000v1
75 downloads
382 views

Viruses could have originated from the frantic competition to survive among primitive life forms. This is the result of this new hypothesis which proposes that viruses could have originated as remnants of the disintegration of primitive microorganisms. The disintegration...

["Evolutionary Studies","Virology"]
doi:10.7287/peerj.preprints.1801v2
83 downloads
269 views

With the emergence of Next Generation Sequencing, major advances were made with regard to identifying viruses in natural environments. However, bioinformatical research on viruses is still limited because of the low amounts of viral DNA that can be obtained for...

["Biodiversity","Genomics","Microbiology","Virology"]
doi:10.7287/peerj.preprints.2912v1
23 downloads
150 views

The identification of Parrot bornaviruses in psittacine birds with proventricular dilatation disease (PDD) has not been sufficient to explain the pathogenesis of this fatal disease since not all infected birds develop clinical signs. One hypothesis suggests that...

["Veterinary Medicine","Virology","Pathology"]
doi:10.7287/peerj.preprints.2852v1
67 downloads
241 views

Background: Geminivirus (family Geminiviridae) is a prevalent plant virus that imperils agriculture globally, causing serious damage to the livelihood of farmers, particularly in developing countries. The virus evolves rapidly, attributing to its single-stranded...

["Agricultural Science","Bioinformatics","Genomics","Virology"]
doi:10.7287/peerj.preprints.2705v1
73 downloads
248 views

Diseases of marine mammals can be difficult to diagnose because of the life history and protected status of these animals. Stranded marine mammals have been a particularly useful resource to discover and comprehend the diseases that plague these top predators....

["Aquaculture, Fisheries and Fish Science","Marine Biology","Microbiology","Veterinary Medicine","Virology"]
doi:10.7287/peerj.preprints.2457v1
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