Preprints (not yet peer-reviewed)

58 downloads
62 views

Background. The Ebola Virus Disease (EVD) is a highly infectious disease that has claimed over 25,000 cases in the past 50 years. While many past outbreaks of EVD resulted in relatively few incidents, the 2014 outbreak in West Africa was the most deadly occurrence...

["Virology","Epidemiology","Infectious Diseases","Statistics"]
doi:10.7287/peerj.preprints.3021v1
7 downloads
97 views

Live attenuated viral vaccines provide the most robust and longest lasting immune response. Yet designing them a priori to have reduced growth capacity and also to be robust to evolutionary reversion can be challenging. On the one hand, genome editing methods now...

["Evolutionary Studies","Virology"]
doi:10.7287/peerj.preprints.3001v1
15 downloads
145 views

Influenza A viruses cause an annual highly contagious respiratory disease in humans, and are responsible for periodic human pandemics that have high mortality rates. Pandemic influenza A viruses can result from reassortment of one or more gene segments between...

["Evolutionary Studies","Microbiology","Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.3000v1
59 downloads
330 views

Viruses could have originated from the frantic competition to survive among primitive life forms. This is the result of this new hypothesis which proposes that viruses could have originated as remnants of the disintegration of primitive microorganisms. The disintegration...

["Evolutionary Studies","Virology"]
doi:10.7287/peerj.preprints.1801v2
31 downloads
210 views

With the emergence of Next Generation Sequencing, major advances were made with regard to identifying viruses in natural environments. However, bioinformatical research on viruses is still limited because of the low amounts of viral DNA that can be obtained for...

["Biodiversity","Genomics","Microbiology","Virology"]
doi:10.7287/peerj.preprints.2912v1
17 downloads
114 views

The identification of Parrot bornaviruses in psittacine birds with proventricular dilatation disease (PDD) has not been sufficient to explain the pathogenesis of this fatal disease since not all infected birds develop clinical signs. One hypothesis suggests that...

["Veterinary Medicine","Virology","Pathology"]
doi:10.7287/peerj.preprints.2852v1
51 downloads
213 views

Background: Geminivirus (family Geminiviridae) is a prevalent plant virus that imperils agriculture globally, causing serious damage to the livelihood of farmers, particularly in developing countries. The virus evolves rapidly, attributing to its single-stranded...

["Agricultural Science","Bioinformatics","Genomics","Virology"]
doi:10.7287/peerj.preprints.2705v1
37 downloads
191 views

Diseases of marine mammals can be difficult to diagnose because of the life history and protected status of these animals. Stranded marine mammals have been a particularly useful resource to discover and comprehend the diseases that plague these top predators....

["Aquaculture, Fisheries and Fish Science","Marine Biology","Microbiology","Veterinary Medicine","Virology"]
doi:10.7287/peerj.preprints.2457v1
58 downloads
144 views

An acute outbreak of porcine hemagglutinating encephalomyelitis virus (PHEV) infection in piglets, characterized with neurological symptoms, vomiting, diarrhea, and wasting, occurred in China. Coronavirus-like particles were observed in the homogenized tissue suspensions...

["Veterinary Medicine","Virology"]
doi:10.7287/peerj.preprints.2351v1
87 downloads
262 views

Background – Corns are hard protuberances that occur on the digital footpads of Greyhound dogs. The cause of these lesions is unknown and there is little information about them in the veterinary literature. We received anecdotal examples of dog to dog spread of...

["Molecular Biology","Veterinary Medicine","Virology"]
doi:10.7287/peerj.preprints.2290v1
171 downloads
494 views

Zika virus (ZIKV), a mosquito borne disease, has been linked to congenital anomalies in humans. Recent outbreaks of ZIKV have caused the scientific community to focus on this previously neglected pathogen. Information regarding phosphorylation potential of ZIKV...

["Bioinformatics","Computational Biology","Virology"]
doi:10.7287/peerj.preprints.2047v2
42 downloads
314 views

The baculovirus expression vector system (BEVS) has been widely used to produce a large number of recombinant proteins, and is becoming one of the most powerful, robust, and cost-effective systems for the production of eukaryotic proteins. Nevertheless, as in any...

["Biotechnology","Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.2024v1
280 downloads
319 views

A major limitation with traditional phage preparations is the variability in titer, salts, and bacterial contaminants between successive propagations. Here we introduce the Phage On Tap (PoT) protocol for the quick and efficient preparation of homogenous bacteriophage...

["Microbiology","Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.1966v1
92 downloads
332 views

Members of the Caliciviridae family of positive sense RNA viruses cause a wide range of diseases in both humans and animals. The detailed characterization of the calicivirus life cycle had been hampered due to the lack of robust cell culture systems and experimental...

["Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.1960v1
204 downloads
471 views

The advent of metagenomic methods to sequence DNA directly from an environment has revolutionized viral ecology, making it possible to “see” natural viral communities that could not be previously studied through culture. This technological leap has enabled further...

["Bioinformatics","Genomics","Molecular Biology","Virology"]
doi:10.7287/peerj.preprints.1901v1
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