Preprints (not yet peer-reviewed)

17 downloads
59 views

This detailed analysis provides an insight into aging processes in the human organism. The developmental program that controls the regulation of gene expression through epigenetic modifications leads to cellular senescence in the latter life. This epigenetic development...

["Cell Biology","Developmental Biology","Genetics","Molecular Biology"]
doi:10.7287/peerj.preprints.26998v1
25 downloads
106 views

The processes of association and dissociation of ribosomal subunits are of great importance for the protein biosynthesis. The mechanistic details of these processes, however, are not well known. In bacteria, upon translation termination, ribosome dissociates into...

["Biochemistry","Molecular Biology"]
doi:10.7287/peerj.preprints.26997v1
47 downloads
347 views

Human primary T cells are invaluable and feasible model systems to study the characteristics of the immune cells in various contexts, including but not limited to cancer immunotherapy. Following isolation of T cells from fresh human blood samples, it is possible...

["Cell Biology","Genetics","Molecular Biology","Immunology"]
doi:10.7287/peerj.preprints.26993v1
131 downloads
187 views

The existence of eukaryotic ribosomes with distinct ribosomal protein (RP) stoichiometry and regulatory roles in protein synthesis been speculated for over sixty years. Recent advances in mass spectrometry and high throughput analysis have begun to identify and...

["Biochemistry","Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.26991v1
26 downloads
137 views

Background: Laccases, copper-based polyphenol oxidases, played vital roles in lignin and humus degradation as well as fruiting body formation and stress response. Sixteen putative laccase genes (Lacc1-Lacc16) were reported in the genome of white-rot fungus Ganoderma...

["Agricultural Science","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26982v1
25 downloads
119 views

Background. Intramuscular fat (IMF) is an important economic trait for pork quality and a complex quantitative trait regulated by multiple genes. The objective of this work was to investigate the novel transcriptional effects of a multigene pathways on IMF deposition...

["Agricultural Science","Bioinformatics","Molecular Biology"]
doi:10.7287/peerj.preprints.26976v1
65 downloads
175 views

Clustered regularly interspersed short palindromic repeats (CRISPR) is a natural defense system for bacteria and archaea against foreign DNA and RNA. Specifically, short snippets of foreign DNA or RNA are incorporated into protospacer adjacent motif (PAM) repeats...

["Biochemistry","Bioengineering","Biotechnology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26975v1
160 downloads
326 views

The cellular abundance of proteins can vary even between isogenic single cells. This variability between single-cell protein levels can have functional roles, such as controlling cell fate during apoptosis induction or the proliferation/quiescence decision. Here,...

["Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.26965v1
89 downloads
113 views

A major obstacle to high-throughput genotyping of micro-hymenoptera is their small size. As species are difficult to discriminate and because complexes may exist, the sequencing of a pool of specimens is hazardous. Thus, one should be able to sequence pangenomic...

["Biodiversity","Entomology","Genomics","Molecular Biology","Taxonomy"]
doi:10.7287/peerj.preprints.26939v1
841 downloads
1,691 views

The viability of DNA metabarcoding for assessment of freshwater macrozoobenthos has been demonstrated over the past years. It matured to a stage where it can be applied to monitoring at a large scale, keeping pace with increased high throughput sequencing (HTS)...

["Molecular Biology","Freshwater Biology"]
doi:10.7287/peerj.preprints.3456v4
22 downloads
103 views

Proteolysis is increasingly documented as a method of regulation of mitochondrial function. Our studies of rhomboidfamily proteins’ roles in organelles show that this is also the case in the social amoeba Dictyostelium discoideum, in which four of these membrane-bound,...

["Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26930v1
44 downloads
200 views

Glacial–interglacial climate oscillations during the Pleistocene played a significant role in shifting species distributions. During this period (26 500 - 19 000 years ago) the sea level was 120 m lower than it is currently with large areas of the Southern African...

["Conservation Biology","Marine Biology","Molecular Biology","Plant Science"]
doi:10.7287/peerj.preprints.26927v1
151 downloads
485 views

Background. Comparative genomics between closely related bacterial strains can distinguish important features determining pathogenesis, antibiotic resistance, and phylogenetic structure. The Streptococcus genus is relevant to public health and food safety and it...

["Biodiversity","Bioinformatics","Genomics","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26665v2
36 downloads
119 views

Coping with nutritional stress is essential for cell survival, of which many strategies at the cellular level lend support for ensuring the survival of the population at a particular habitat. One postulated mechanism is swarming motility in bacterial cells, where,...

["Biochemistry","Bioengineering","Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26914v1
76 downloads
124 views

Temperature affects growth of bacteria by influencing enzyme and growth kinetics. Specifically, evolution selects for specific temperature range in which a microbe could thrive, and thus fix the temperature range in which biomolecule structure and function are...

["Biochemistry","Biotechnology","Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26901v1
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