Preprints (not yet peer-reviewed)

Cytokines are fundamental for a functioning immune system, and thus, potentially serve as important indicators of animal health. Quantitation of mRNA using quantitative reverse transcription polymerase chain reaction (qRT-PCR) is an established immunological technique....

["Marine Biology","Molecular Biology","Veterinary Medicine","Immunology"]
doi:10.7287/peerj.preprints.2735v1

Development of drug resistance limits the effectiveness of anticancer treatments. Understanding the molecular mechanisms triggering this event in tumor cells may lead to improved therapeutic strategies. Here we used RNA-seq to compare the transcriptomes of an erythroleukemia...

["Molecular Biology","Hematology"]
doi:10.7287/peerj.preprints.2731v1
462 downloads
1,627 views

A central challenge in the present era of biodiversity loss is to assess and manage human impacts on freshwater ecosystems. Macroinvertebrates are an ideal group for Environmental Impacts Assessment (EIA). However, generating accurate macroinvertebrate inventories...

["Biodiversity","Bioinformatics","Ecology","Genetics","Molecular Biology"]
doi:10.7287/peerj.preprints.2044v4
2 downloads
55 views

Structure informs function, and this may be the evolutionary reason why alternative splicing, which is capable of generating different variants of the same protein, arise. But, given the energetic cost of generating different splice variants for testing their capability...

["Biochemistry","Bioinformatics","Genomics","Molecular Biology","Anatomy and Physiology"]
doi:10.7287/peerj.preprints.2717v1
4 downloads
60 views

Background: Lysyl oxidases (LOX) were studied mostly in mammals, whereas properties of recently found homologs in prokaryotic genomes remain enigmatic. Methods: LOX gene from Haloterrigena turkmenica has been cloned by PCR in a E. coli expression vector. Protein...

["Biochemistry","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.2691v1
7 downloads
63 views

The repair of DNA from alkylation damage is generally performed by evolutionary conserved protein complexes. However, specific repair of O6-alkylated-guanines is a task of a small class of proteins called AGTs (alkylated DNA-protein alkyl-transferases): by using...

["Biochemistry","Molecular Biology"]
doi:10.7287/peerj.preprints.2683v1
12 downloads
106 views

Type I restriction-modification enzymes are multisubunit, multifunctional molecular machines that recognize specific DNA target sequences, and their multisubunit organization underlies their multifunctionality. EcoR124I is the archetype of Type I restriction-modification...

["Biochemistry","Biophysics","Computational Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2680v1
11 downloads
52 views

Background: Gerbera delavayi Franch., a perennial herb native to southwest China, is of important and special value in textile and culture. Its abaxial leaves have a layer of soft fibers, which can be manually peeled, twisted into a yarn, and applied in textiles...

["Conservation Biology","Genetics","Molecular Biology","Plant Science"]
doi:10.7287/peerj.preprints.2656v1
8 downloads
152 views

Intracellular calcium ion (Ca2+) signaling is deeply involved in development, as demonstrated by the use of various Ca2+ sensors. Ca2+ patterns in wildtype and mutant zebrafish have been reported to date, however, not many zebrafish embryos with congenital anomaly...

["Developmental Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2644v1
13 downloads
88 views

Quality disciplines have been widely used for decades in industrial and business fields. It is only in recent times, however, that Quality management and approaches have received proper attention in life science. In particular, the need for Quality standards in...

["Cell Biology","Food Science and Technology","Genetics","Molecular Biology","Science Policy"]
doi:10.7287/peerj.preprints.2637v1
79 downloads
109 views

Synthetic biology is often misunderstood as creation of artificial life or new biology using principles different from those of extant organisms around us. But, fundamentally, the field is about engineering biology in a more efficient and effective way, and endowing...

["Biochemistry","Bioengineering","Biotechnology","Computational Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2634v1
96 downloads
134 views

Microorganisms are tightly bounded to the animals on Earth. Bacteria, among other types of microbes, interact with their hosts in several ways regarding metabolic pathways, development, complex behavioral processes such as mate recognition, among others. The adult...

["Animal Behavior","Biodiversity","Conservation Biology","Molecular Biology","Zoology"]
doi:10.7287/peerj.preprints.2627v1
74 downloads
261 views

In the face of increasing threats to biodiversity, the advancement of methods for surveying biological communities is a major priority for ecologists. Recent advances in molecular biological technologies have made it possible to detect and sequence DNA from environmental...

["Biodiversity","Ecology","Marine Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2608v1
26 downloads
200 views

The adaptative bleaching hypothesis (ABH) states that depending on the symbiotic flexibility of coral hosts (i.e., the ability of corals to “switch” or “shuffle” their algal symbionts), coral bleaching can lead to a change in the composition of their associated...

["Biodiversity","Ecology","Marine Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2607v1
74 downloads
114 views

Cardiovascular disease is the leading cause of morbidity and mortality worldwide. In 2008 alone, 17.3 million deaths (representing 30% of all deaths) were attributable to the complications of cardiovascular disease. Of these deaths, 7.3 million were due to coronary...

["Cell Biology","Molecular Biology","Cardiology","Science and Medical Education"]
doi:10.7287/peerj.preprints.2586v1
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