Preprints (not yet peer-reviewed)

Natural product libraries are important tools for drug discovery. However, until now, there has not been a system to allow projections of the potential number of hits from creating these libraries. The objective of this study was to develop a stochastic model system...

["Biodiversity","Biotechnology","Microbiology","Drugs and Devices","Computational Science"]
doi:10.7287/peerj.preprints.2734v1
23 downloads
143 views

Residence time (τ) is the average amount of time that particles spend in an ecosystem. Often estimated from the ratio of volume to flow rate, τ equates the physical environment with dynamics of growth. Here, we propose that τ is key to understanding relationships...

["Biodiversity","Ecology","Ecosystem Science","Microbiology"]
doi:10.7287/peerj.preprints.2727v1
8 downloads
67 views

River structures and their ecosystem funtciotns have been greatly destructed due to the human disturbance during the last decades. It is a pressing task to understand the complete structures and ecosystem functions of a natural river to restore the impired river...

["Ecology","Ecosystem Science","Environmental Sciences","Microbiology"]
doi:10.7287/peerj.preprints.2712v1
5 downloads
46 views

The biological activities of quinoxalone, a novel small molecular substance isolated from the broth of the myxobacterium Stigmatella eracta WXNXJ-B, was investigated. This study was designed to determine the anti-proliferative, apoptotic property of quinoxalone,...

["Biotechnology","Microbiology","Pharmacology"]
doi:10.7287/peerj.preprints.2703v1
4 downloads
60 views

Background: Lysyl oxidases (LOX) were studied mostly in mammals, whereas properties of recently found homologs in prokaryotic genomes remain enigmatic. Methods: LOX gene from Haloterrigena turkmenica has been cloned by PCR in a E. coli expression vector. Protein...

["Biochemistry","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.2691v1
7 downloads
93 views

Marker gene sequencing of microbial communities has generated big datasets of microbial relative abundances varying across environmental conditions, sample sites and treatments. These data often come with putative phylogenies, providing unique opportunities to...

["Computational Biology","Ecology","Mathematical Biology","Microbiology","Statistics"]
doi:10.7287/peerj.preprints.2685v1
3 downloads
53 views

Considering the difficulty of breeding endangered species in captivity relative to those in the wild, specific environmental factors such as availability of roaming space and nutrition may be important reasons contributing to the relative lack of procreation capability...

["Animal Behavior","Biochemistry","Conservation Biology","Microbiology","Zoology"]
doi:10.7287/peerj.preprints.2686v1
19 downloads
117 views

It has been reported that the intracellular pH of the budding yeast Saccharomyces cerevisiae is asymmetric between mother and daughter cells, and this asymmetry in pH underlies replicative aging and rejuvenation. S. cerevisiae growth morphology changes between...

["Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.2684v1
5 downloads
50 views

Background: The gastrointestinal tract (GIT) microbiota is essential to metabolic health, and the prevalence of the Western diet (WD) high in fat and sugar is increasing, with evidence highlighting a negative interaction between the GIT and WD resulting in liver...

["Microbiology","Veterinary Medicine","Zoology"]
doi:10.7287/peerj.preprints.2681v1
27 downloads
218 views

Cyanobacteria are major contributors to global biogeochemical cycles. The genetic diversity among Cyanobacteria enables them to thrive across many habitats. However, the taxonomy of Cyanobacteria remains unstable because of an inadequate taxonomic classification...

["Bioinformatics","Ecology","Genomics","Microbiology","Taxonomy"]
doi:10.7287/peerj.preprints.2676v1
6 downloads
32 views

Acinetobacter baumannii has emerged as an important pathogen related to serious infections and nosocomial outbreaks around the world. The aim of this study was to detect the distribution of carbapenemases and efflux pump in carbopenems-resistance Acinetobacter...

["Microbiology"]
doi:10.7287/peerj.preprints.2655v1
79 downloads
743 views

Press disturbances are stressors that are extended or ongoing relative to the generation times of community members, and, due to their longevity, have the potential to alter communities beyond the possibility of recovery. They also provide key opportunities to...

["Biodiversity","Ecology","Environmental Sciences","Microbiology","Soil Science"]
doi:10.7287/peerj.preprints.2446v2
28 downloads
331 views

The genetic structure of bacterial populations can be related to geographical locations of isolation. In some species, there is a strong correlation between geographical distances and genetic distances, which can be caused by different evolutionary mechanisms....

["Biogeography","Bioinformatics","Genomics","Microbiology","Epidemiology"]
doi:10.7287/peerj.preprints.2638v1
37 downloads
123 views

In the present study, Okara, a soybean by-product from the production of tofu and soymilk, was processed by solid state fermentation (SSF) with Neurospora crassa Mai 1-1, a filamentous and edible fungus which was firstly isolated in our group. The proximate composition,...

["Food Science and Technology","Microbiology","Nutrition"]
doi:10.7287/peerj.preprints.2636v1
32 downloads
159 views

Cascaded performance and compartments of constructed wetlands may harbor the internal eco-environmental gradients and further differentiate the niche and community structure of ammonia-oxidizing archaea (AOA). Here, we used quantitative PCR and 454 pyrosequencing...

["Biodiversity","Ecology","Microbiology"]
doi:10.7287/peerj.preprints.2629v1
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