Preprints (not yet peer-reviewed)

172 downloads
277 views

“Omics” studies generate long lists of genes, proteins, metabolites or other features which can be difficult to decipher. Feature set enrichment analysis utilizing annotated groups/classes of features (such as pathways, gene ontology terms or gene/metabolic modules)...

["Bioinformatics","Immunology","Statistics","Metabolic Sciences","Computational Science"]
doi:10.7287/peerj.preprints.2420v1
82 downloads
205 views

In aggressive solid tumors like melanoma, a strategy for therapy personalization can be achieved by combining high-throughput data on the patient’s specific tumor mutation and expression profiles. A remarkable case is dendritic cell-based immunotherapy, where tumor...

["Bioinformatics","Dermatology","Immunology"]
doi:10.7287/peerj.preprints.2385v1
35 downloads
104 views

Snakebite envenomings represent a neglected public health issue in many parts of the rural tropical world. Animal-derived antivenoms have existed for more than a hundred years and are effective in neutralizing snake venom toxins when timely administered. However,...

["Bioinformatics","Biotechnology","Toxicology","Immunology","Synthetic Biology"]
doi:10.7287/peerj.preprints.2364v1
48 downloads
177 views

Different types of stem cells are targeted by a number of cytokines that alter proliferation, differentiation, or other properties of stem cells. Stem cells are known to express various cytokine genes. As IL-12, IL-14, G-CSF, and GM-CSF expression is lost after...

["Allergy and Clinical Immunology","Immunology"]
doi:10.7287/peerj.preprints.2347v1
169 downloads
278 views

Background. With 214 million cases and 438,000 deaths in 2015, malaria remains one of the deadliest infectious diseases in tropical countries. Several species of the protozoan Plasmodium cause malaria. However, almost all the fatalities are due to Plasmodium falciparum,...

["Parasitology","Global Health","Immunology","Infectious Diseases"]
doi:10.7287/peerj.preprints.1918v1
98 downloads
299 views

Introduction Age is the primary risk factor for major human chronic diseases, including cardiovascular disorders, cancer, type 2 diabetes, and neurodegenerative diseases. Chronic, low-grade, systemic inflammation is associated with aging and the progression of...

["Computational Biology","Microbiology","Geriatrics","Immunology"]
doi:10.7287/peerj.preprints.1754v1
148 downloads
195 views

Genes of the major histocompatibility complex (MHC) are of great interest to molecular ecologists due to their role in the immune response and the complex evolutionary mechanisms affecting their abundance and distribution. Next generation sequencing (NGS) offers...

["Bioinformatics","Molecular Biology","Zoology","Immunology"]
doi:10.7287/peerj.preprints.1662v1
119 downloads
181 views

Biomedical knowledge is growing exponentially; however, meta-knowledge around the data is often lacking. PubMed is a database comprising more than 21 million citations for biomedical literature from MEDLINE and additional life science journals dating back to the...

["Bioinformatics","Computational Biology","Cardiology","Evidence Based Medicine","Immunology"]
doi:10.7287/peerj.preprints.1446v1
133 downloads
543 views

Current strategies to improve graft outcome following kidney transplantation consider information at the HLA loci. Here, we used exome sequencing of DNA from ABO compatible kidney graft recipients and their living donors to determine recipient and donor mismatches...

["Genomics","Immunology","Nephrology"]
doi:10.7287/peerj.preprints.854v2
41 downloads
129 views

Background. Epigenetic influences have been implicated in the development of autoimmunity. While such mechanisms have been linked to mouse models of intestinal inflammation, and to human inflammatory bowel disease (IBD), the involvement of epigenetic mechanisms...

["Molecular Biology","Gastroenterology and Hepatology","Immunology"]
doi:10.7287/peerj.preprints.1391v1
97 downloads
155 views

Vertebrate mothers transfer diverse compounds to developing embryos that can affect their development and final phenotype (i.e. maternal effects). However, the way such effects modulate offspring phenotype, in particular their immunity remains unclear. To test...

["Evolutionary Studies","Virology","Zoology","Immunology","Infectious Diseases"]
doi:10.7287/peerj.preprints.1380v1
86 downloads
186 views

Acute carbon monoxide poisoning (ACMP) is one of the most common types of poisoning worldwide, and may result in delayed encephalopathy, however, its pathogenesis remains obscure and there is no optimal treatment strategy for the patients with ACMP. Here, we developed...

["Immunology","Neurology"]
doi:10.7287/peerj.preprints.1226v1
95 downloads
221 views

Overcoming drug-resistance is one of the major challenges to control tuberculosis (TB). The up-regulation of efflux pumps is one common mechanism that leads to drug-resistance. Therefore, immunotherapy targeting these efflux pump antigens could be promising strategy...

["Biochemistry","Microbiology","Immunology"]
doi:10.7287/peerj.preprints.987v1
36 downloads
234 views

Objective: Chronic nasal carriage of Staphylococcus aureus (SA) increases the risk of relapse while Rituximab (RTX) is an effective agent for inducing and maintaining remission in patients with Granulomatosis with polyangiitis (GPA). We investigated whether B cell...

["Allergy and Clinical Immunology","Immunology","Infectious Diseases","Internal Medicine","Rheumatology"]
doi:10.7287/peerj.preprints.972v1
206 downloads
283 views

In this Opinion piece, I argue that the dynamics of viruses and the cellular immune response depend on the body size of the host. I use allometric scaling theory to interpret observed quantitative differences in the infection dynamics of lymphocytic choriomeningitis...

["Ecology","Mathematical Biology","Microbiology","Virology","Immunology"]
doi:10.7287/peerj.preprints.803v2
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