Preprints (not yet peer-reviewed)

38 downloads
130 views

The 'Hygiene hypothesis', a cornerstone model to account for the role of exogenous pathogens and later of endogenous microbiota in immune disorders, is currently presumed to operate at the innate immunity and metabolite levels to properly 'educate' the immune system....

["Immunology"]
doi:10.7287/peerj.preprints.3237v1
60 downloads
241 views

Prevailing immunological dogma dictates self-nonself discrimination, meaning to respond or not, and effector class regulation, meaning choosing the most effective response, are two separate decisions the immune system makes when faced with a new antigen. Representing...

["Immunology"]
doi:10.7287/peerj.preprints.3081v1
21 downloads
131 views

Chlamydia trachomatis is usally isolated only from humans and is often infected together with other sexually transmitted diseases(STD). C. trachomatis is a serious disease which infects 500 million people per year globally and causes blindness in 7 to 9 million...

["Biochemistry","Microbiology","Molecular Biology","Immunology","Infectious Diseases"]
doi:10.7287/peerj.preprints.3056v1
23 downloads
318 views

BACKGROUND: 2’-4’ Dinitrofluorobenzene (DNFB) induced contact hypersensitivity is an established model of contact sensitivity and leukocyte migration. Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) deficient mice were used to examine the role of PECAM-1...

["Cell Biology","Dermatology","Immunology"]
doi:10.7287/peerj.preprints.2947v2
61 downloads
214 views

Cytokines are fundamental for a functioning immune system, and thus, potentially serve as important indicators of animal health. Quantitation of mRNA using quantitative reverse transcription polymerase chain reaction (qRT-PCR) is an established immunological technique....

["Marine Biology","Molecular Biology","Veterinary Medicine","Immunology"]
doi:10.7287/peerj.preprints.2735v1
386 downloads
667 views

“Omics” studies generate long lists of genes, proteins, metabolites or other features which can be difficult to decipher. Feature set enrichment analysis utilizing annotated groups/classes of features (such as pathways, gene ontology terms or gene/metabolic modules)...

["Bioinformatics","Immunology","Statistics","Metabolic Sciences","Computational Science"]
doi:10.7287/peerj.preprints.2420v1
194 downloads
451 views

In aggressive solid tumors like melanoma, a strategy for therapy personalization can be achieved by combining high-throughput data on the patient’s specific tumor mutation and expression profiles. A remarkable case is dendritic cell-based immunotherapy, where tumor...

["Bioinformatics","Dermatology","Immunology"]
doi:10.7287/peerj.preprints.2385v1
69 downloads
199 views

Snakebite envenomings represent a neglected public health issue in many parts of the rural tropical world. Animal-derived antivenoms have existed for more than a hundred years and are effective in neutralizing snake venom toxins when timely administered. However,...

["Bioinformatics","Biotechnology","Toxicology","Immunology","Synthetic Biology"]
doi:10.7287/peerj.preprints.2364v1
283 downloads
293 views

Different types of stem cells are targeted by a number of cytokines that alter proliferation, differentiation, or other properties of stem cells. Stem cells are known to express various cytokine genes. As IL-12, IL-14, G-CSF, and GM-CSF expression is lost after...

["Allergy and Clinical Immunology","Immunology"]
doi:10.7287/peerj.preprints.2347v1
254 downloads
390 views

Background. With 214 million cases and 438,000 deaths in 2015, malaria remains one of the deadliest infectious diseases in tropical countries. Several species of the protozoan Plasmodium cause malaria. However, almost all the fatalities are due to Plasmodium falciparum,...

["Parasitology","Global Health","Immunology","Infectious Diseases"]
doi:10.7287/peerj.preprints.1918v1
118 downloads
419 views

Introduction Age is the primary risk factor for major human chronic diseases, including cardiovascular disorders, cancer, type 2 diabetes, and neurodegenerative diseases. Chronic, low-grade, systemic inflammation is associated with aging and the progression of...

["Computational Biology","Microbiology","Geriatrics","Immunology"]
doi:10.7287/peerj.preprints.1754v1
218 downloads
354 views

Genes of the major histocompatibility complex (MHC) are of great interest to molecular ecologists due to their role in the immune response and the complex evolutionary mechanisms affecting their abundance and distribution. Next generation sequencing (NGS) offers...

["Bioinformatics","Molecular Biology","Zoology","Immunology"]
doi:10.7287/peerj.preprints.1662v1
160 downloads
290 views

Biomedical knowledge is growing exponentially; however, meta-knowledge around the data is often lacking. PubMed is a database comprising more than 21 million citations for biomedical literature from MEDLINE and additional life science journals dating back to the...

["Bioinformatics","Computational Biology","Cardiology","Evidence Based Medicine","Immunology"]
doi:10.7287/peerj.preprints.1446v1
159 downloads
697 views

Current strategies to improve graft outcome following kidney transplantation consider information at the HLA loci. Here, we used exome sequencing of DNA from ABO compatible kidney graft recipients and their living donors to determine recipient and donor mismatches...

["Genomics","Immunology","Nephrology"]
doi:10.7287/peerj.preprints.854v2
60 downloads
219 views

Background. Epigenetic influences have been implicated in the development of autoimmunity. While such mechanisms have been linked to mouse models of intestinal inflammation, and to human inflammatory bowel disease (IBD), the involvement of epigenetic mechanisms...

["Molecular Biology","Gastroenterology and Hepatology","Immunology"]
doi:10.7287/peerj.preprints.1391v1
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