Preprints (not yet peer-reviewed)

412 downloads
396 views

Primary care services in England may be reaching saturation point. Demands to see a GP or practice nurse have increased substantially. Clinical complexity has also increased; patients are living longer, but with more multimorbidity.(1) These demands are mirrored...

["Emergency and Critical Care","Evidence Based Medicine","Science Policy"]
doi:10.7287/peerj.preprints.15934v1
106 downloads
411 views

Statistical significance provides evidence for or against an explanation of a population of interest, not a description of data sampled from the population. This simple distinction gets ignored in hundreds of thousands of research publications yearly, which confuse...

["Ecology","Evidence Based Medicine","Oncology","Statistics","Environmental Impacts"]
doi:10.7287/peerj.preprints.3394v1
162 downloads
381 views

Abstract Ginsenoside Rk1 (G-Rk1) is one of the unique components created by processing ginseng at high temperature, in particular of Sun Ginseng (SG). The aim of our study was to systematically review the pharmacological effects of G-Rk1.we conducted our search...

["Plant Science","Evidence Based Medicine","Pharmacology"]
doi:10.7287/peerj.preprints.3013v1
12,413 downloads
791 views

Meta analysis refers to a process of integration of the results of many studies to arrive at evidence syn- thesis. Meta analysis is similar to systematic review; however, in addition to narrative summary that is conducted in systematic review, in meta analysis,...

["Epidemiology","Evidence Based Medicine","Health Policy","Public Health","Statistics"]
doi:10.7287/peerj.preprints.2978v1
3,143 downloads
11,475 views

Background: Paediatric SLT roles often involve planning individualised intervention for specific children (provided directly by SLTs or indirectly through non-SLTs), working collaboratively with families and education staff and providing advice and training. A...

["Cognitive Disorders","Evidence Based Medicine","Pediatrics","Psychiatry and Psychology","Public Health"]
doi:10.7287/peerj.preprints.2951v1
137 downloads
266 views

The “reproducibility crisis” has been a highly visible source of scientific controversy and dispute. Here, I propose and review several avenues for identifying and prioritizing research studies for the purpose of targeted validation. Of the various proposals discussed,...

["Bioinformatics","Evidence Based Medicine","Health Policy","Translational Medicine","Science Policy"]
doi:10.7287/peerj.preprints.2830v1
113 downloads
277 views

Objective: The purpose of this study was to demonstrate the effects of the achievement motive on important variables such as the purpose in life and social participation with objective physical functions in predicting within-person fluctuations and between-person...

["Evidence Based Medicine","Geriatrics","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.2801v1
65 downloads
477 views

BACKGROUND: The use of public engagement and self-management in online clinical trials is growing with benefits, boundaries and minimal methodological guidance. This analysis explores whether running self-recruited online trials can provide trustworthy and useful...

["Clinical Trials","Evidence Based Medicine","Global Health","Public Health","Science and Medical Education"]
doi:10.7287/peerj.preprints.2671v1
490 downloads
492 views

“Open access” has become a central theme of journal reform in academic publishing. In this article, I examine the consequences of an important technological loophole in which publishers can claim to be adhering to the principles of open access by releasing articles...

["Bioinformatics","Evidence Based Medicine","Health Policy","Translational Medicine","Science Policy"]
doi:10.7287/peerj.preprints.2566v1
183 downloads
263 views

Developing new endpoints for mobility is an important strategic aim for many groups both in industry and academia and the focus of a growing field. Bringing those novel endpoints to health authority acceptance for clinical decision making will require a concerted...

["Clinical Trials","Evidence Based Medicine","Translational Medicine","Computational Science"]
doi:10.7287/peerj.preprints.2546v1
388 downloads
257 views

This is a tutorial on how to use the GRADEPro GDT guidelines development tool for appraisal of articles. The tutorial assumes that the student has little experience of working with Gradepro and walks through in several steps how to use this tool. Grading of evidence...

["Evidence Based Medicine","Science and Medical Education"]
doi:10.7287/peerj.preprints.2520v1
81 downloads
244 views

Background: Achievement motive is expected to prevent lack of self-efficacy and hope, which negatively impact rehabilitation support, health, and psychological well-being. It has been indicated that the factor structure of the Scale for Achievement Motive in Rehabilitation...

["Epidemiology","Evidence Based Medicine","Geriatrics","Psychiatry and Psychology","Public Health"]
doi:10.7287/peerj.preprints.2459v1
74 downloads
288 views

The study of subjective, first-person experience is a topic with both philosophical and practical implications. In this article, I discuss the value of collecting a critical mass of prose or verbal descriptions of introspectively determined, subjective effects...

["Toxicology","Evidence Based Medicine","Neurology","Pharmacology","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.2424v1
75 downloads
541 views

Nuclear transfer techniques (a.k.a. mitochondrial replacement therapies) are currently under development to provide a route to eliminating particular instances of mitochondrial disease from the germline. Before these kinds of techniques are implemented clinically...

["Evolutionary Studies","Genetics","Genomics","Evidence Based Medicine","Statistics"]
doi:10.7287/peerj.preprints.2412v1
118 downloads
334 views

Introduction Hospital readmissions are common, expensive, and a key target of the Medicare Value Based Purchasing (VBP) program. Risk assessment tools have been developed to identify patients at high risk of hospital readmission so they can be targeted for interventions...

["Evidence Based Medicine","Health Policy","Internal Medicine"]
doi:10.7287/peerj.preprints.2093v1
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