Preprints (not yet peer-reviewed)

21 downloads
137 views

Purpose: To compare the intraoperative angle stability and the postoperative outflow of two ab interno trabeculectomy devices that excise the trabecular meshwork. The newer device has an active aspiration and irrigation port while the older requires viscoelastic...

["Drugs and Devices","Ophthalmology","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.2762v2
15 downloads
74 views

Natural product libraries are important tools for drug discovery. However, until now, there has not been a system to allow projections of the potential number of hits from creating these libraries. The objective of this study was to develop a stochastic model system...

["Biodiversity","Biotechnology","Microbiology","Drugs and Devices","Computational Science"]
doi:10.7287/peerj.preprints.2734v1
18 downloads
72 views

Drug discovery is a step-by-step process very important in biopharmaceutical field. We are interested in identifying new investigational drug-likes as potential inhibitors of determinate biological-therapeutic targets, trying to decrease the side effects and to...

["Bioinformatics","Computational Biology","Drugs and Devices"]
doi:10.7287/peerj.preprints.2639v1
65 downloads
159 views

Motivation. The human chymase (EC 3.4.21.39) is a hydrolase abundant in secretory granules of mast cells, responsible for the synthesis of angiotensin II from its precursor. Moreover, it is also responsible for the conversion of transforming growth factor-β (TGF-β)...

["Biochemistry","Bioinformatics","Computational Biology","Drugs and Devices"]
doi:10.7287/peerj.preprints.2185v1
22 downloads
103 views

It is well known that the biological properties of compounds are directly related to the configuration of their stereogenic centers. Therefore, the determination of the compound spatial structure, including its configuration, is crucial for better understanding...

["Biophysics","Drugs and Devices","Science and Medical Education"]
doi:10.7287/peerj.preprints.1935v1
131 downloads
207 views

Background: Arterial thrombosis causes heart attacks and strokes and constitutes one of the leading causes of morbidity and mortality in the world and few therapies are available for its treatment. Thus, new therapeutic approaches in the prevention and treatment...

["Biochemistry","Bioinformatics","Cardiology","Drugs and Devices"]
doi:10.7287/peerj.preprints.1919v1
19 downloads
110 views

The copper(I)-mediated reaction of nitrones with terminal acetylenes, known as the Kinugasa reaction, represents an attractive method of direct formation of the β-lactam ring. The reaction can be performed in many ways. Diastereoselective versions, including cyclic...

["Drugs and Devices","Synthetic Biology"]
doi:10.7287/peerj.preprints.1917v1
102 downloads
120 views

Pemetrexed is an antifolate antineoplastic agent that acts by inhibiting the formation of precursor purine and pyrimidine nucleotides. Pemetrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal and cancer cells....

["Drugs and Devices"]
doi:10.7287/peerj.preprints.1910v1
31 downloads
237 views

Conventional methods in this field include identifying and screening compounds in a laboratory setting with cells and animals, and then moving on to clinical trials with promising compounds. To complicate the issue with these methods, effective compounds might...

["Clinical Trials","Drugs and Devices"]
doi:10.7287/peerj.preprints.1902v1
47 downloads
135 views

Amides represent an important class of compounds in chemistry, chemical biology and pharmaceutical industry. Their broad utility in many fields is closely tied to the structure of the amide moiety which endows these compounds with unique features. The low reactivity...

["Drugs and Devices","Synthetic Biology"]
doi:10.7287/peerj.preprints.1770v2
31 downloads
135 views

Fullerene molecules are created entirely of carbon and form orbicular or ellipsoidal cage shape similar to a hollow tube. The derivatives of fullerenes are classified into the following categories according to their functionalization: endohedral fullerenes with...

["Drugs and Devices","Science and Medical Education","Computational Science"]
doi:10.7287/peerj.preprints.1869v1
33 downloads
95 views

Fullerene molecules are created entirely of carbon and have a highly unusual attributes. The one of the fullerene derivatives are heterofullerenes when one or more carbon atoms that form the fullerene carbon cage are replaced by a non-carbon atom, i.e., a heteroatom....

["Drugs and Devices","Science and Medical Education"]
doi:10.7287/peerj.preprints.1865v1
295 downloads
297 views

Background: Glioblastoma multiforme (GBM) is a grade IV brain tumor that arises from star-shaped glial cells supporting neural cells called astrocytes. The survival of GBM patients remains poor despite many specific molecular targets that have been developed and...

["Biochemistry","Bioinformatics","Computational Biology","Drugs and Devices","Oncology"]
doi:10.7287/peerj.preprints.1582v3
68 downloads
124 views

According to the World Health Organization, one of the criteria for the standardized assessment of case causality in adverse drug reactions is the temporal relationship between the intake of a drug and the occurrence of a reaction or a laboratory test abnormality....

["Drugs and Devices","Pharmacology","Computational Science"]
doi:10.7287/peerj.preprints.1846v1
34 downloads
160 views

The core tasks of the Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte [BfArM]) with respect to medical device safety include evaluating risks arising from the use or application of medical devices (based on incident...

["Drugs and Devices","Psychiatry and Psychology","Human-Computer Interaction"]
doi:10.7287/peerj.preprints.1840v1
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