Preprints (not yet peer-reviewed)

37 downloads
128 views

Background. Currently, the number of obese people in the world has reached alarming proportions. During the expansion of adipose tissue, a number of functions such as activation and release of cytokines and hormones may be affected. This causes the body to take...

["Diabetes and Endocrinology","Nutrition"]
doi:10.7287/peerj.preprints.2535v1
113 downloads
177 views

Steroids play multiple roles in the regulation of development, physiology, reproduction, and behavior. Measuring circulating steroids is especially challenging since concentrations are extremely labile, responding to stressors within minutes. Matrices that integrate...

["Andrology","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.2069v2
71 downloads
306 views

Aim/hypothesis The aim of our study was to characterize the human salivary proteome and determine the changes in protein expression in 2 different stages of diabetic retinopathy with type-2 diabetes mellitus: (1) with non-proliferative diabetic retinopathy (NPDR)...

["Biochemistry","Diabetes and Endocrinology","Ophthalmology"]
doi:10.7287/peerj.preprints.1973v1
303 downloads
299 views

Purpose. Type 2 diabetes is the leading cause of end stage renal disease in the United States. Atherosclerotic renal artery stenosis is commonly observed in diabetic patients and impacts the rate of renal and cardiovascular disease progression. We hypothesized...

["Cardiology","Diabetes and Endocrinology","Nephrology","Pathology","Translational Medicine"]
doi:10.7287/peerj.preprints.1323v2
110 downloads
214 views

The growing number of wildlife endocrinology studies have greatly enhanced our understanding of comparative endocrinology, and have also generated extensive longitudinal data for a vast number of species. However, the extensive graphical analysis required for these...

["Biodiversity","Computational Biology","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.1546v1
133 downloads
160 views

Type 2 diabetes mellitus (T2DM) is a chronic and progressive disease that is strongly associated with the all-cause and cardiovascular mortality. The present study aimed to analyze the abundance and functionality of intrinsically disordered regions in several biomarkers...

["Biochemistry","Bioinformatics","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.1395v1
890 downloads
475 views

Whether obesity is a disease or a risk factor of chronic diseases including diabetes and fatty liver remains debating. We report here that a high-fat diet (HFD) alone or HFD and intramuscular injection of mice with a high dose (1.2 mg/kg) of lipopolysaccharide...

["Diabetes and Endocrinology","Pathology","Pharmacology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.1229v1
150 downloads
269 views

The metabolic syndrome (MS) affects 21-53% of patients with chronic obstructive pulmonary disease (COPD) with a higher prevalence in the early stages of COPD, with results being highly variable between studies. MS may also correlate with disease characteristics....

["Diabetes and Endocrinology","Epidemiology","Internal Medicine","Respiratory Medicine"]
doi:10.7287/peerj.preprints.1022v1
287 downloads
341 views

INTRODUCTION: Diabetic retinopathy affects majority (70% to 90%) of diabetic patients, causes visual impairment which leads to severe psycho-social disruption in life. Our objective was to study the patients of diabetic retinopathy, co-relate between the types...

["Diabetes and Endocrinology","Ophthalmology","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.981v1
320 downloads
297 views

Diabetes mellitus (DM) affects 2-37% of patients with chronic obstructive pulmonary disease (COPD), with results being highly variable between studies. DM may also correlate with disease characteristics.The aim of this study was to examine the prevalence of DM...

["Diabetes and Endocrinology","Epidemiology","Internal Medicine","Respiratory Medicine"]
doi:10.7287/peerj.preprints.939v1
75 downloads
403 views

It is unclear whether the adipokine chemerin has pro- or anti-inflammatory properties, plays any role in the aetiology of obesity or type 2 diabetes, or whether agonists or antagonists of the chemerin receptor CMKLR1 have potential in the treatment of these diseases....

["Diabetes and Endocrinology","Pharmacology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.643v1
39 downloads
201 views

Kv1 channels are shaker-related potassium channels that influence insulin sensitivity. Kv1.3 -/- mice are protected from diet-induced insulin resistance and some studies suggest that Kv1.3 inhibitors provide similar protection. However, it is unclear whether blockade...

["Biochemistry","Diabetes and Endocrinology","Pharmacology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.498v1
356 downloads
369 views

Metabolic dysfunction in skeletal muscle is a major contributor to the development of type 2 diabetes. Endurance exercise training has long been established as an effective means to directly restore skeletal muscle glucose and lipid uptake and metabolism. However,...

["Molecular Biology","Diabetes and Endocrinology","Kinesiology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.410v1
266 downloads
247 views

Background: Cardiovascular disease is a major cause of death in the western world. Regular physical activity is known to be highly beneficial for improving cardiovascular health status. Methods:The current abstract is based on the authors own data and a literature...

["Cell Biology","Diabetes and Endocrinology","Epidemiology","Kinesiology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.367v1
396 downloads
328 views

We determined the effect of butyrate and other short-chain fatty acids (SCFA) on rates of lipolysis in 3T3-L1 adipocytes. Prolonged treatment with butyrate (5 mM) increased the rate of lipolysis approximately 2-3-fold. Aminobutyric acid and acetate had little or...

["Biochemistry","Cell Biology","Diabetes and Endocrinology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.312v1
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