Preprints (not yet peer-reviewed)

Lesion of the dopaminergic neurons of the nigrostriatal system is a key feature of Parkinson's disease (PD). Alpha-synuclein is a protein that is a major component of Lewy bodies, histopathological hallmarks of PD, and is involved in regulation of dopamine (DA)...

["Developmental Biology","Neuroscience","Neurology","Pathology"]
doi:10.7287/peerj.preprints.26547v1
10 downloads
26 views

In vertebrates, it has been argued that the development and evolution of an enlarged brain requires an increased basal metabolic rate or a compensatory reduction in the resources devoted to the formation of other metabolically costly tissues, leading to a reduction...

["Anthropology","Developmental Biology","Evolutionary Studies"]
doi:10.7287/peerj.preprints.26543v1
83 downloads
239 views

Background. The sustainable methods of propagation for Typha domingensis through somatic embryogenesis can help to mitigate its current condition of ecological marginalisation and overexploitation. Then, the hypothesis established that the variation of the concentration...

["Biotechnology","Developmental Biology","Plant Science","Histology","Freshwater Biology"]
doi:10.7287/peerj.preprints.26459v1
64 downloads
133 views

Parkinson’s disease is a widespread condition caused by degeneration of dopamine neurons in the midbrain. A number of proteins are known to be important to signalling mechanisms present in the midbrain during natural dopamine neuron development, and may be utilised...

["Bioinformatics","Developmental Biology","Neuroscience"]
doi:10.7287/peerj.preprints.26443v2
29 downloads
136 views

Purpose: This study was performed to investigate the expression pattern of Wnt inhibitory factor 1 (Wif1) during anorectal development in normal and anorectal malformation (ARM) embryos and the possible role of Wif1 in the pathogenesis of ARM. Methods: ARM was...

["Developmental Biology","Gastroenterology and Hepatology","Pediatrics"]
doi:10.7287/peerj.preprints.3459v1
117 downloads
254 views

The discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka in 2006 was heralded as a major breakthrough of the decade in stem cell research. The ability to reprogrammed human somatic cells to a pluripotent embryonic stem cell-like state through...

["Cell Biology","Developmental Biology","Genetics"]
doi:10.7287/peerj.preprints.3374v1
40 downloads
191 views

Although comparative studies of anuran ontogeny have provided new data on heterochrony in the life cycles of frogs, most of them have not included Colombian species. Using different staining techniques, we describe the cranial and poscranial elements development...

["Biodiversity","Developmental Biology","Evolutionary Studies","Taxonomy","Zoology"]
doi:10.7287/peerj.preprints.3368v1
73 downloads
207 views

Many plant species exhibit heterophylly, displaying different leaves upon a single plant. The molecular mechanisms regulating this phenomenon, however, have remained elusive. In this study, the transcriptomes of submerged and floating leaves of an aquatic heterophyllous...

["Cell Biology","Developmental Biology","Evolutionary Studies","Genetics","Plant Science"]
doi:10.7287/peerj.preprints.3336v1
174 downloads
479 views

Phenotypic differences between closely related taxa or populations can arise through genetic variation or be environmentally induced, in both cases leading to altered transcription of genes during the structural and functional development of the body. Comparative...

["Developmental Biology","Ecology","Evolutionary Studies","Genomics","Freshwater Biology"]
doi:10.7287/peerj.preprints.3318v1
57 downloads
206 views

Quality disciplines have been widely used for decades in industrial and business fields. It is only in recent times, however, that Quality management and approaches have received proper attention in life science. The development, optimization, validation and dissemination...

["Biochemistry","Cell Biology","Developmental Biology","Ethical Issues","Science Policy"]
doi:10.7287/peerj.preprints.3316v1
50 downloads
384 views

The study of ontogeny in the fossil record is complicated by two main factors: growth series are not available for many taxa, and correctly assigning juveniles and adults to the same taxon is often difficult, especially where several related taxa coexisted. Ontogenetic...

["Developmental Biology","Evolutionary Studies","Marine Biology","Paleontology","Zoology"]
doi:10.7287/peerj.preprints.3162v2
119 downloads
689 views

AMNH FARB 291 is a unique sauropod dinosaur specimen, excavated in 1898 from the Bone Cabin Quarry of Wyoming (Upper Jurassic; Morrison Formation). It consists of a sequence of five contiguous dorsal vertebrae, all with biconvex centra: a morphology not previously...

["Developmental Biology","Evolutionary Studies","Paleontology"]
doi:10.7287/peerj.preprints.3144v2
801 downloads
541 views

One of the great mysteries of the brain, which has puzzled all-time students of brain form and function is the contralateral organization of the forebrain, and the crossings of its major afferent and efferent connections. As a novel explanation, two recent studies...

["Developmental Biology","Neuroscience","Zoology"]
doi:10.7287/peerj.preprints.432v3
76 downloads
122 views

It is well documented that coordination of feeding behavior in anuran amphibians requires precise coordination of the jaw levators and depressors with the timing of the protraction of the tongue. (for review, see Nishikawa, 2000). However, the neuronal mechanism...

["Developmental Biology","Neuroscience"]
doi:10.7287/peerj.preprints.3131v1
88 downloads
176 views

Mitochondria cannot be produced de novo by the cell, but are inherited across generations. Their peculiar genetics (multiple genomes per cell, no meiosis, replication independent from cell cycle, high mutation rate) and the possible exposition to Reactive Oxygen...

["Developmental Biology","Evolutionary Studies"]
doi:10.7287/peerj.preprints.3122v1
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