Preprints (not yet peer-reviewed)

37 downloads
326 views

BACKGROUND: The use of public engagement and self-management in online clinical trials is growing with benefits, boundaries and minimal methodological guidance. This analysis explores whether running self-recruited online trials can provide trustworthy and useful...

["Clinical Trials","Evidence Based Medicine","Global Health","Public Health","Science and Medical Education"]
doi:10.7287/peerj.preprints.2671v1
32 downloads
164 views

We comment on the recent developments and problems of three-dimensional printing in cardiology. Since there are currently no standards or consensuses for 3D printing in clinical medicine and the technology is at its infancy in cardiology, it’s very important to...

["Anatomy and Physiology","Cardiology","Clinical Trials","Radiology and Medical Imaging"]
doi:10.7287/peerj.preprints.2597v1
105 downloads
137 views

Developing new endpoints for mobility is an important strategic aim for many groups both in industry and academia and the focus of a growing field. Bringing those novel endpoints to health authority acceptance for clinical decision making will require a concerted...

["Clinical Trials","Evidence Based Medicine","Translational Medicine","Computational Science"]
doi:10.7287/peerj.preprints.2546v1
61 downloads
119 views

Wearable physiological sensors have the projected capability to detect unknown and unreported health conditions. Development requires rounds of discovery-oriented human subject research and confirmatory clinical trials. However, each study is a significant investment...

["Clinical Trials","Epidemiology","Infectious Diseases","Public Health","Ethical Issues"]
doi:10.7287/peerj.preprints.2079v1
53 downloads
200 views

Background. Interventions and services for people with mental health problems can have broad remits: they are often designed to treat people with a variety of diagnoses. Furthermore, addressing mental health problems can have long term implications for economic,...

["Clinical Trials","Evidence Based Medicine","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.1988v1
51 downloads
209 views

In publication of a controlled trial article from health science research, the abstract is an important part that readers usually read first and then decide whether to read the whole article; therefore, information provided in the abstract should be adequate. The...

["Agricultural Science","Veterinary Medicine","Clinical Trials","Evidence Based Medicine"]
doi:10.7287/peerj.preprints.1945v1
32 downloads
242 views

Conventional methods in this field include identifying and screening compounds in a laboratory setting with cells and animals, and then moving on to clinical trials with promising compounds. To complicate the issue with these methods, effective compounds might...

["Clinical Trials","Drugs and Devices"]
doi:10.7287/peerj.preprints.1902v1
48 downloads
95 views

Background: Simtics Integrated Cognitive Simulator (ICS) is a software learning environment, previously demonstrated to be of use to surgical trainees in learning the cognitive aspects of procedural skills. It also includes a Test-Mode, which has not previously...

["Clinical Trials","Surgery and Surgical Specialties","Human-Computer Interaction","Computational Science"]
doi:10.7287/peerj.preprints.1893v1
646 downloads
377 views

The FDA adaptive trial design guidance (1) is a thoughtful but lengthy document that explains on 50 pages wide-ranging and important topics “such as ... what aspects of adaptive design trials (i.e., clinical, statistical, regulatory) call for special consideration,...

["Clinical Trials","Drugs and Devices","Statistics"]
doi:10.7287/peerj.preprints.1825v1
280 downloads
1,706 views

Background. Imaging biomarkers hold tremendous promise in the precision medicine clinical applications. Development of such biomarkers relies heavily on image post-processing tools for automated image quantitation. Their deployment in the context of clinical research...

["Bioinformatics","Clinical Trials","Oncology","Radiology and Medical Imaging"]
doi:10.7287/peerj.preprints.1541v3
57 downloads
160 views

Biological medicinal products are one of most innovative and promising methods of pharmacotherapy. During the last 20 years several original biological medicinal products have been registered and marketed. Their safety and efficacy have been investigated thoroughly...

["Biotechnology","Clinical Trials"]
doi:10.7287/peerj.preprints.1699v1
59 downloads
1,946 views

There are numerous medical disorders without effective treatments. It is possible that many of un-treatable conditions need more than one compound co-operatively for improvement or cure. Approval of drugs in the U.S. is governed by a rigorous review process by...

["Clinical Trials","Evidence Based Medicine","Health Policy","Public Health"]
doi:10.7287/peerj.preprints.1626v1
190 downloads
722 views

Background: Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulatory technique that has shown encouraging results regarding performance improvement of normal subjects in tests of executive functions. Moreover, when applied repeatedly in...

["Clinical Trials","Neurology","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.1610v1
96 downloads
201 views

Olmesartan belongs to a class of drugs called angiotensin II receptor blockers (ARBs). It works by relaxing blood vessels so that blood can flow more easily and is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes,...

["Clinical Trials","Pharmacology"]
doi:10.7287/peerj.preprints.1540v1
39 downloads
226 views

Bosentan is a drug used in the treatment of pulmonary arterial hypertension. Evaluation of bosentan pharmacokinetics is an important step of the drug development. The aim of our study was to evaluate bioanalytical method reliability by assessing the influence of...

["Clinical Trials","Pharmacology"]
doi:10.7287/peerj.preprints.1539v1
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