Preprints (not yet peer-reviewed)

4 downloads
30 views

Background. Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in the development and function of multiple organs and organ systems, including the central nervous system (CNS). FGF signaling via FGFR1, one of the three FGFRs expressed in...

["Cell Biology","Developmental Biology","Neuroscience"]
doi:10.7287/peerj.preprints.2729v1
19 downloads
117 views

It has been reported that the intracellular pH of the budding yeast Saccharomyces cerevisiae is asymmetric between mother and daughter cells, and this asymmetry in pH underlies replicative aging and rejuvenation. S. cerevisiae growth morphology changes between...

["Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.2684v1
18 downloads
40 views

Background. Increases in oceanic temperatures are expected to affect the cellular function of ecologically important organisms, such as sponges. Sponges are important to biodiversity, coral reef systems, benthic and spongiverous organisms, and the biomedical industry....

["Cell Biology","Conservation Biology","Ecology","Environmental Sciences","Marine Biology"]
doi:10.7287/peerj.preprints.2654v1
13 downloads
85 views

Quality disciplines have been widely used for decades in industrial and business fields. It is only in recent times, however, that Quality management and approaches have received proper attention in life science. In particular, the need for Quality standards in...

["Cell Biology","Food Science and Technology","Genetics","Molecular Biology","Science Policy"]
doi:10.7287/peerj.preprints.2637v1
74 downloads
114 views

Cardiovascular disease is the leading cause of morbidity and mortality worldwide. In 2008 alone, 17.3 million deaths (representing 30% of all deaths) were attributable to the complications of cardiovascular disease. Of these deaths, 7.3 million were due to coronary...

["Cell Biology","Molecular Biology","Cardiology","Science and Medical Education"]
doi:10.7287/peerj.preprints.2586v1
23 downloads
129 views

Identifying the pathways that control a cellular phenotype is the first step to building a mechanistic model. Recent examples in developmental biology, cancer genomics, and neurological disease have demonstrated how changes in the variability of gene expression...

["Bioinformatics","Cell Biology","Statistics"]
doi:10.7287/peerj.preprints.2585v1
30 downloads
83 views

Backgound. Death associated protein kinase 1 (DAPK) is an important tumor suppressor kinase involved in the regulation of multiple cellular activities such as apoptosis and autophagy. DNA methylation of DAPK gene was found in various types of cancers and often...

["Cell Biology"]
doi:10.7287/peerj.preprints.2568v1
57 downloads
225 views

The evolutionarily conserved Mediator complex is a critical player in regulating transcription. Comprised of approximately two dozen proteins, Mediator integrates diverse regulatory signals through direct protein-protein interactions that, in turn, modulate the...

["Cell Biology","Developmental Biology","Evolutionary Studies","Molecular Biology"]
doi:10.7287/peerj.preprints.2530v2
30 downloads
145 views

Background. Bax Inhibitor-1 (BI-1), an integral transmembrane protein, acts as a suppressor of Bax-induced apoptosis through regulation of endoplasmic reticulum (ER) stress-induced cell death. The gene is highly conserved being found in a diverse range of organisms...

["Cell Biology","Genetics","Neuroscience"]
doi:10.7287/peerj.preprints.2548v1
18 downloads
92 views

Here we shall apply the approach presented in the paper Dynamics of resource allocation in biological systems in considering resource allocation in cancer cell metabolism, specifically, aerobic glycolysis (Warburg effect). Aerobic glycolysis, the metabolic phenomenon...

["Biochemistry","Cell Biology","Mathematical Biology","Molecular Biology","Oncology"]
doi:10.7287/peerj.preprints.2533v1
12 downloads
101 views

Here we present a single working model that attempts at reconciliation of biological systems. To do this we recognize and emphasize a universal theme of all biological systems: a need for resources. That is, we consider the dynamics of resource allocation as a...

["Biochemistry","Cell Biology","Mathematical Biology","Anatomy and Physiology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.2503v1
33 downloads
211 views

Chlamydia suis is a swine pathogen that also causes zoonotic infections. Many strains contain a tet(C) cassette conferring tetracycline resistance originally acquired by horizontal gene transfer from a Gram-negative donor. As we and others have described the capacity...

["Cell Biology","Genomics","Microbiology","Molecular Biology","Infectious Diseases"]
doi:10.7287/peerj.preprints.2489v1
22 downloads
103 views

Background. Oxidative stress could induce cell injury in vascular endothelial cells, which is the initial event in the development of atherosclerosis. Although quantitative real-time polymerase chain reaction (qRT-PCR) has been widely used in gene expression studies...

["Cell Biology","Molecular Biology","Cardiology"]
doi:10.7287/peerj.preprints.2460v1
35 downloads
172 views

The subcellular positioning of chloroplasts can be changed by alterations in the environment such as light and temperature. For example, in leaf mesophyll cells, chloroplasts localize along anticlinal cell walls under high-intensity light, and along periclinal...

["Cell Biology","Plant Science"]
doi:10.7287/peerj.preprints.2425v1
22 downloads
111 views

Background. White adipose tissue (WAT) is a complex, disperse, multifunctional organ which contains adipocytes, and a large proportion of fat, but also other cell types, active in defence, regeneration and signalling functions. Studies with adipocytes often require...

["Cell Biology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.2371v1
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