Preprints (not yet peer-reviewed)

6 downloads
89 views

The secretory pathway in Plasmodium falciparum has evolved to transport proteins to the host cell membrane and to an endosymbiotic organelle, the apicoplast. The latter can occur via the ER or the ER-Golgi route. Here, we study these three routes using proteins...

["Cell Biology","Parasitology"]
doi:10.7287/peerj.preprints.2813v1
11 downloads
69 views

It is now widely accepted that oligomers consisting of Aβ peptide are the cytotoxic species contributing mostly to the development of Alzheimer’s disease. Aβ peptide production results from the specific proteolytic processing of the amyloid precursor protein (APP)....

["Biophysics","Biotechnology","Cell Biology","Molecular Biology","Neuroscience"]
doi:10.7287/peerj.preprints.2804v1
14 downloads
68 views

Cancer spread away from the primary tumour towards other parts of the body is what is most feared in cancer treatment, and is the leading cause of relapse for patients who are in remission after initial rounds of treatment with surgery, radiation or chemotherapy....

["Biochemistry","Cell Biology","Marine Biology","Molecular Biology","Histology"]
doi:10.7287/peerj.preprints.2800v1
14 downloads
77 views

Symbiotic bacteria are common in insects and can affect various aspects of their hosts’ biology. Although the effects of insect symbionts have been clarified for various insect symbiosis models, due to the difficulty of cultivating them in vitro, there is still...

["Cell Biology","Entomology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.2799v1
687 downloads
512 views

Divergence of treatment responses to chemotherapy exists across patients (often with unknown underlying mechanisms), with some patients exhibiting worsened outcome upon treatment. Genomic approaches (such as microarray profiling and whole genome sequencing) hold...

["Bioengineering","Bioinformatics","Cell Biology","Genomics","Histology"]
doi:10.7287/peerj.preprints.1049v6
18 downloads
71 views

BACKGROUNDː This article describes the characterization of a new cell line (IRB-1), which was established from an Iranian child with retinoblastoma. METHODSː Using cell culture techniques, we isolated a clonal population from primary Cultures of retinoblastoma...

["Cell Biology","Oncology","Ophthalmology"]
doi:10.7287/peerj.preprints.2780v1
34 downloads
119 views

Cellular heterogeneity is important to biological processes, including cancer and development. However, proteome heterogeneity is largely unexplored because of the limitations of existing methods for quantifying protein levels in single cells. To alleviate these...

["Biochemistry","Cell Biology","Computational Biology","Developmental Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2767v1
21 downloads
94 views

Background: Food preservation is essential to the growing world population, food economy. Freezing is a commonly used method for food preservation. While extending the life of the product, freezing has detrimental effects. It is causing loss of food weight and...

["Agricultural Science","Biophysics","Cell Biology","Food Science and Technology","Plant Science"]
doi:10.7287/peerj.preprints.2740v1
15 downloads
93 views

Background. Fibroblast growth factors (FGFs) and their receptors (FGFRs) are involved in the development and function of multiple organs and organ systems, including the central nervous system (CNS). FGF signaling via FGFR1, one of the three FGFRs expressed in...

["Cell Biology","Developmental Biology","Neuroscience"]
doi:10.7287/peerj.preprints.2729v1
90 downloads
265 views

It has been reported that the intracellular pH of the budding yeast Saccharomyces cerevisiae is asymmetric between mother and daughter cells, and this asymmetry in pH underlies replicative aging and rejuvenation. S. cerevisiae growth morphology changes between...

["Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.2684v1
29 downloads
76 views

Background. Increases in oceanic temperatures are expected to affect the cellular function of ecologically important organisms, such as sponges. Sponges are important to biodiversity, coral reef systems, benthic and spongiverous organisms, and the biomedical industry....

["Cell Biology","Conservation Biology","Ecology","Environmental Sciences","Marine Biology"]
doi:10.7287/peerj.preprints.2654v1
22 downloads
117 views

Quality disciplines have been widely used for decades in industrial and business fields. It is only in recent times, however, that Quality management and approaches have received proper attention in life science. In particular, the need for Quality standards in...

["Cell Biology","Food Science and Technology","Genetics","Molecular Biology","Science Policy"]
doi:10.7287/peerj.preprints.2637v1
92 downloads
122 views

Cardiovascular disease is the leading cause of morbidity and mortality worldwide. In 2008 alone, 17.3 million deaths (representing 30% of all deaths) were attributable to the complications of cardiovascular disease. Of these deaths, 7.3 million were due to coronary...

["Cell Biology","Molecular Biology","Cardiology","Science and Medical Education"]
doi:10.7287/peerj.preprints.2586v1
23 downloads
148 views

Identifying the pathways that control a cellular phenotype is the first step to building a mechanistic model. Recent examples in developmental biology, cancer genomics, and neurological disease have demonstrated how changes in the variability of gene expression...

["Bioinformatics","Cell Biology","Statistics"]
doi:10.7287/peerj.preprints.2585v1
37 downloads
98 views

Backgound. Death associated protein kinase 1 (DAPK) is an important tumor suppressor kinase involved in the regulation of multiple cellular activities such as apoptosis and autophagy. DNA methylation of DAPK gene was found in various types of cancers and often...

["Cell Biology"]
doi:10.7287/peerj.preprints.2568v1
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