Preprints (not yet peer-reviewed)

18 downloads
165 views

Maximakinin (MK), an amphibian peptide possessing the C-terminal sequence of bradykinin (BK), is a BK B2 receptor (B2R) agonist eliciting prolonged signaling. We reinvestigated this 19-mer for species-specific pharmacologic profile, in vivo confirmation of resistance...

["Cardiology","Pharmacology"]
doi:10.7287/peerj.preprints.2641v1
36 downloads
209 views

We comment on the recent developments and problems of three-dimensional printing in cardiology. Since there are currently no standards or consensuses for 3D printing in clinical medicine and the technology is at its infancy in cardiology, it’s very important to...

["Anatomy and Physiology","Cardiology","Clinical Trials","Radiology and Medical Imaging"]
doi:10.7287/peerj.preprints.2597v1
227 downloads
171 views

Cardiovascular disease is the leading cause of morbidity and mortality worldwide. In 2008 alone, 17.3 million deaths (representing 30% of all deaths) were attributable to the complications of cardiovascular disease. Of these deaths, 7.3 million were due to coronary...

["Cell Biology","Molecular Biology","Cardiology","Science and Medical Education"]
doi:10.7287/peerj.preprints.2586v1
73 downloads
196 views

Background. Oxidative stress could induce cell injury in vascular endothelial cells, which is the initial event in the development of atherosclerosis. Although quantitative real-time polymerase chain reaction (qRT-PCR) has been widely used in gene expression studies...

["Cell Biology","Molecular Biology","Cardiology"]
doi:10.7287/peerj.preprints.2460v1
181 downloads
297 views

Background: Arterial thrombosis causes heart attacks and strokes and constitutes one of the leading causes of morbidity and mortality in the world and few therapies are available for its treatment. Thus, new therapeutic approaches in the prevention and treatment...

["Biochemistry","Bioinformatics","Cardiology","Drugs and Devices"]
doi:10.7287/peerj.preprints.1919v1
316 downloads
384 views

Purpose. Type 2 diabetes is the leading cause of end stage renal disease in the United States. Atherosclerotic renal artery stenosis is commonly observed in diabetic patients and impacts the rate of renal and cardiovascular disease progression. We hypothesized...

["Cardiology","Diabetes and Endocrinology","Nephrology","Pathology","Translational Medicine"]
doi:10.7287/peerj.preprints.1323v2
47 downloads
279 views

Background. The diagnosis of non-adherence is complex and there are no completely reliable methods that can be used widely in daily practice. The aim of this study was to validate electronic prescriptions as a method of measuring treatment adherence in patients...

["Cardiology","Health Policy","Pharmacology","Legal Issues","Human-Computer Interaction"]
doi:10.7287/peerj.preprints.1538v1
143 downloads
270 views

Biomedical knowledge is growing exponentially; however, meta-knowledge around the data is often lacking. PubMed is a database comprising more than 21 million citations for biomedical literature from MEDLINE and additional life science journals dating back to the...

["Bioinformatics","Computational Biology","Cardiology","Evidence Based Medicine","Immunology"]
doi:10.7287/peerj.preprints.1446v1
45 downloads
192 views

Several positively charged epitopes on the surface of CXCL8 involved in the binding of the major components of endothelial glycocalyx, sulfated glycosaminoglycans (GAGs).In the present study, we aimed to test the hypothesis that the surface GAGs — heparan sulfate...

["Cell Biology","Molecular Biology","Cardiology"]
doi:10.7287/peerj.preprints.1421v1
280 downloads
422 views

Computational modelling of cardiac cellular electrophysiology has a long history, with many models now available for different species, cell types, and experimental preparations. This success brings with it a challenge: how do we assess and compare the underlying...

["Biophysics","Computational Biology","Cardiology","Computational Science"]
doi:10.7287/peerj.preprints.1338v1
44 downloads
282 views

BACKGROUND: The ischemic damage of the sinus node (SN) is a well known cause of cardiac arrhythmias and can be a consequence of any flow abnormality in the sinus node artery (SNA). Accordingly we aimed this retrospective study to: 1. evaluate the suitability of...

["Cardiology","Evidence Based Medicine","Hematology","Internal Medicine","Radiology and Medical Imaging"]
doi:10.7287/peerj.preprints.1204v1
311 downloads
501 views

Background: Summertime dips in blood pressure (BP), both in normotensive and hypertensive subjects, are well known. However, the dips are small and are not related to particular forms or doses of antihypertensive medication. Nevertheless it is the practice in some...

["Cardiology"]
doi:10.7287/peerj.preprints.144v3
37 downloads
252 views

Background: While single-institution studies reported the indications and outcomes of tracheostomy in children with congenital heart disease (CHD), no national analyses have been performed. We sought to examine the indications, performance, outcomes, and resource...

["Anaesthesiology and Pain Management","Cardiology","Epidemiology","Pediatrics","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.465v1
561 downloads
376 views

Platelets expose phosphatidylserine (PS), a component of the prothrombinase complex, on the outer surface of the plasma membrane when activated. [ref 1] The prothrombinase complex catalyzes the conversion of prothrombin to thrombin, and it has been demonstrated...

["Anatomy and Physiology","Cardiology","Hematology"]
doi:10.7287/peerj.preprints.351v1
1,004 downloads
362 views

Cardiopulmonary Resuscitation (CPR) is a simple and effective medical treatment for sudden cardiac arrest patients. Because of those existing interferences in the experiments, most of the animal experiments and the CPRs in vivo studies get contradictory conclusions....

["Anatomy and Physiology","Cardiology","Translational Medicine","Computational Science","Science and Medical Education"]
doi:10.7287/peerj.preprints.334v1
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