Preprints (not yet peer-reviewed)

76 downloads
236 views

This report summarizes the scientific content and activities of the second edition of the Brazilian Student Council Symposium organized by the Regional Student Group Brazil (RSG-Brazil), a branch of the International Society for Computational Biology (ISCB). The...

["Bioinformatics","Science and Medical Education"]
doi:10.7287/peerj.preprints.26521v1
18 downloads
60 views

Accurate detection of target microbial species in metagenomic datasets from environmental samples remains limited because the limit of detection of current methods is typically inaccessible and the frequency of false-positives, resulting from inadequate identification...

["Bioinformatics","Genomics"]
doi:10.7287/peerj.preprints.26515v1
172 downloads
596 views

Evolutionary biology has entered an era of unprecedented amounts of DNA sequence data, as new sequencing platforms such as Massive Parallel Sequencing (MPS) can generate billions of nucleotides within less than a day. The current bottleneck is how to efficiently...

["Bioinformatics","Computational Biology","Evolutionary Studies","Genetics"]
doi:10.7287/peerj.preprints.26477v3
10 downloads
37 views

Ribosomes are highly conserved given the importance of protein synthesis to cell survival. Although small differences in structure and functions exists in ribosomes from different species of bacteria, archaea and eukaryotes, the general structure and function remains...

["Biochemistry","Bioinformatics","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.26511v1
36 downloads
115 views

We describe the scientific community of an India effort, the Bioinfomatics Club for Experimenting Scientists (Bioclues) whose aim works on four avenues, viz. Mentoring, Outreach, Research and Entrepreneurship (MORE). Incepted in the year 2005, the organization...

["Bioinformatics","Biotechnology","Ethical Issues","Science and Medical Education","Science Policy"]
doi:10.7287/peerj.preprints.26503v1
29 downloads
113 views

Background: Zika virus (ZIKV) is an arbovirus that belongs to family Flaviviridae. The virus has emerged as a global threat and no FDA approved vaccine is available, so an efficient vaccine needs to be designed in order to prevent the infection. Computationally...

["Bioinformatics","Computational Biology"]
doi:10.7287/peerj.preprints.26499v1
324 downloads
1,000 views

Background. DNA metabarcoding is used to generate species composition data for entire communities. However, sequencing errors in high throughput sequencing instruments are fairly common, usually requiring reads to be clustered into operational taxonomic units (OTU),...

["Biogeography","Bioinformatics","Molecular Biology","Freshwater Biology"]
doi:10.7287/peerj.preprints.3269v2
23 downloads
81 views

Proteins that modify the activity of transcription factor (TF), often called modulators, play a vital role in gene transcriptional regulation. Alternative splicing is a critical step of gene processing and it can modulate gene function by adding or removing certain...

["Bioengineering","Bioinformatics","Biotechnology","Genetics","Computational Science"]
doi:10.7287/peerj.preprints.26482v1
21,278 downloads
60,589 views

The website Sci-Hub enables users to download PDF versions of scholarly articles, including many articles that are paywalled at their journal’s site. Sci-Hub has grown rapidly since its creation in 2011, but the extent of its coverage was unclear. Here we report...

["Bioinformatics","Legal Issues","Science and Medical Education","Statistics","Computational Science"]
doi:10.7287/peerj.preprints.3100v3
114 downloads
452 views

Exogenous sequence contamination presents a challenge in first-draft genomes because it can lead to non-contiguous, chimeric assembled sequences. This can mislead downstream analyses reliant on synteny, such as linkage-based analyses. Recently, the Mojave Desert...

["Bioinformatics","Computational Biology","Evolutionary Studies","Genomics","Computational Science"]
doi:10.7287/peerj.preprints.3266v4
14 downloads
76 views

Background. Hepatitis C Virus (HCV) is a major causative agent of liver infection leading to critical liver damage. In response to HCV, the improper regulation of host immune system leads to chronic infection. The host immune system employs multiple cell types,...

["Bioinformatics","Computational Biology"]
doi:10.7287/peerj.preprints.26456v1
61 downloads
129 views

Parkinson’s disease is a widespread condition caused by degeneration of dopamine neurons in the midbrain. A number of proteins are known to be important to signalling mechanisms present in the midbrain during natural dopamine neuron development, and may be utilised...

["Bioinformatics","Developmental Biology","Neuroscience"]
doi:10.7287/peerj.preprints.26443v2
700 downloads
1,331 views

Background: Taxonomic classification of marker-gene sequences is an important step in microbiome analysis. Results: We present q2-feature-classifier ( https://github.com/qiime2/q2-feature-classifier ), a QIIME 2 plugin containing several novel machine-learning...

["Bioinformatics","Microbiology","Taxonomy"]
doi:10.7287/peerj.preprints.3208v2
78 downloads
141 views

DataScope is a web-based tool for generating interactive visual dashboards on large scale multidimensional datasets. Users can use these dashboards to explore data and create cohorts for downstream analysis. We describe DataScope's architecture, design considerations...

["Bioinformatics","Human-Computer Interaction","Visual Analytics"]
doi:10.7287/peerj.preprints.26441v1
113 downloads
569 views

Background. The phytohormone jasmonates (JAs) regulate fundamental plant processes; such as the anthocyanin accumulation during ripening of strawberry, a non-climacteric fruit model. Jasmonoyl-isoleucine (JA-Ile), one of the bioactive JA molecules, mediates binding...

["Biochemistry","Bioinformatics","Computational Biology","Computational Science"]
doi:10.7287/peerj.preprints.2772v2
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