Preprints (not yet peer-reviewed)

12 downloads
78 views

Hydrolysis of ATP by Na+/K+-ATPase, a P-Type ATPase, catalyzing active Na+ and K+ transport through cellular membranes leads transiently to a phosphorylation of its catalytical α-subunit. Surprisingly, 3-dimensional molecular structure analysis of P-type ATPases...

["Biochemistry","Bioinformatics","Biophysics","Computational Biology","Computational Science"]
doi:10.7287/peerj.preprints.2812v1
772 downloads
648 views

The past influences the present and future; for example, in computational chemistry, simplifying assumptions and approximations important in the pre-computing era remains relevant today in allowing simulation of larger systems with reasonable amount of computer...

["Biochemistry","Bioengineering","Biophysics","Computational Biology","Computational Science"]
doi:10.7287/peerj.preprints.365v4
14 downloads
68 views

Cancer spread away from the primary tumour towards other parts of the body is what is most feared in cancer treatment, and is the leading cause of relapse for patients who are in remission after initial rounds of treatment with surgery, radiation or chemotherapy....

["Biochemistry","Cell Biology","Marine Biology","Molecular Biology","Histology"]
doi:10.7287/peerj.preprints.2800v1
22 downloads
77 views

American trypanosomiasis is a chronic and endemic disease, which affects millions of people. Trypanosoma cruzi, its causative agent, has a life cycle that involves complex morphological and functional transitions, as well as a variety of environmental conditions....

["Biochemistry","Genomics","Molecular Biology","Parasitology","Infectious Diseases"]
doi:10.7287/peerj.preprints.2782v1
29 downloads
132 views

Trypanosoma brucei brucei (TBB) belongs to the unicellular parasitic protozoa organisms, specifically to the Trypanosoma genus of the Trypanosomatidae class. A variety of different vertebrate species can be infected by TBB including humans and animals. Under particular...

["Biochemistry","Bioinformatics","Computational Biology","Evolutionary Studies","Parasitology"]
doi:10.7287/peerj.preprints.2775v1
8 downloads
122 views

Background. The phytohormone jasmonates (JAs) regulate fundamental plant processes; such as the anthocyanin accumulation during ripening of strawberry, a non-climacteric fruit model. Jasmonoyl-isoleucine (JA-Ile), one of the bioactive JA molecules, mediates binding...

["Biochemistry","Bioinformatics","Computational Biology","Computational Science"]
doi:10.7287/peerj.preprints.2772v1
39 downloads
120 views

Cellular heterogeneity is important to biological processes, including cancer and development. However, proteome heterogeneity is largely unexplored because of the limitations of existing methods for quantifying protein levels in single cells. To alleviate these...

["Biochemistry","Cell Biology","Computational Biology","Developmental Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2767v1
17 downloads
99 views

The filamentous fungus Rhizopus delemar naturally accumulates relatively high amounts of fumarate. Although the culture conditions that increase fumarate yields are well established, the network underlying the accumulation of fumarate is not yet fully understood....

["Biochemistry","Bioinformatics","Biotechnology","Microbiology"]
doi:10.7287/peerj.preprints.2742v1
14 downloads
66 views

Structure informs function, and this may be the evolutionary reason why alternative splicing, which is capable of generating different variants of the same protein, arise. But, given the energetic cost of generating different splice variants for testing their capability...

["Biochemistry","Bioinformatics","Genomics","Molecular Biology","Anatomy and Physiology"]
doi:10.7287/peerj.preprints.2717v1
7 downloads
74 views

Allelopathic macroalgae have been shown to have significant negative effects on corals via the transfer of toxic compounds. The interaction that takes place between allelopathic macroalgae and other algae, however, has not been studied in detail. Here, the effects...

["Biochemistry","Ecology","Marine Biology"]
doi:10.7287/peerj.preprints.2700v1
13 downloads
73 views

Background: Lysyl oxidases (LOX) were studied mostly in mammals, whereas properties of recently found homologs in prokaryotic genomes remain enigmatic. Methods: LOX gene from Haloterrigena turkmenica has been cloned by PCR in a E. coli expression vector. Protein...

["Biochemistry","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.2691v1
15 downloads
85 views

Considering the difficulty of breeding endangered species in captivity relative to those in the wild, specific environmental factors such as availability of roaming space and nutrition may be important reasons contributing to the relative lack of procreation capability...

["Animal Behavior","Biochemistry","Conservation Biology","Microbiology","Zoology"]
doi:10.7287/peerj.preprints.2686v1
13 downloads
91 views

The repair of DNA from alkylation damage is generally performed by evolutionary conserved protein complexes. However, specific repair of O6-alkylated-guanines is a task of a small class of proteins called AGTs (alkylated DNA-protein alkyl-transferases): by using...

["Biochemistry","Molecular Biology"]
doi:10.7287/peerj.preprints.2683v1
14 downloads
136 views

Type I restriction-modification enzymes are multisubunit, multifunctional molecular machines that recognize specific DNA target sequences, and their multisubunit organization underlies their multifunctionality. EcoR124I is the archetype of Type I restriction-modification...

["Biochemistry","Biophysics","Computational Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.2680v1
13 downloads
65 views

Food components are object of many studies aimed to identify compounds responsible of positive effects in nutrition and food science. Compound categories include antioxidants, whose positive activity is commonly related to their activity in deactivating free radicals....

["Biochemistry","Bioinformatics","Computational Biology"]
doi:10.7287/peerj.preprints.2658v1
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