Preprints (not yet peer-reviewed)

Chlamydia trachomatis is usally isolated only from humans and is often infected together with other sexually transmitted diseases(STD). C. trachomatis is a serious disease which infects 500 million people per year globally and causes blindness in 7 to 9 million...

["Biochemistry","Microbiology","Molecular Biology","Immunology","Infectious Diseases"]
doi:10.7287/peerj.preprints.3056v1
10 downloads
79 views

Background. Aspergillus niger along with many other lignocellulolytic fungi, has been widely used as a commercial workhorse for cellulase production. A fungal cellulase system generally includes three major classes of enzymes i.e. β-glucosidases, endoglucanases...

["Biochemistry","Biotechnology","Molecular Biology"]
doi:10.7287/peerj.preprints.3044v1
17 downloads
82 views

In recent years, the use of lectins for screening of potential biomarkers has gained increased importance in cancer research, given the development in glycobiology that highlights altered structural changes of glycans in cancer associated processes. Lectins, having...

["Biochemistry","Biotechnology","Oncology"]
doi:10.7287/peerj.preprints.3035v1
241 downloads
562 views

Microbes for environmental research should be cultured in growth media with characteristics (e.g., pH, ionic strength, and ionic composition) as close to their original habitat as possible. Additionally, the medium should also enable high cell density to be obtained,...

["Biochemistry","Bioengineering","Biotechnology","Environmental Sciences","Microbiology"]
doi:10.7287/peerj.preprints.1406v5
936 downloads
654 views

Microbes, with their vast metabolic capabilities and great adaptability, occupy almost every conceivable ecological niche on Earth. Thus, could they survive in the oligotrophic (i.e., nutrient poor) deionized (DI) water that we use for experiments? Observations...

["Biochemistry","Biodiversity","Ecology","Environmental Sciences","Microbiology"]
doi:10.7287/peerj.preprints.181v5
189 downloads
868 views

Solid medium enables spatially resolved simultaneous cultivation of different microbes in a simple and relatively low cost format useful for preliminary screening of microbial diversity. Lack of color contrast between colonies and agar, however, hampers colony...

["Biochemistry","Bioengineering","Environmental Sciences","Microbiology"]
doi:10.7287/peerj.preprints.89v5
109 downloads
529 views

Bacteria surface charge mediates important cell-environment and microbe-host interactions, and its accurate and precise measurement by microelectrophoresis requires removing metabolites adhered to the cell surface, where repeated centrifugation and washing by buffers...

["Biochemistry","Biotechnology","Environmental Sciences","Microbiology"]
doi:10.7287/peerj.preprints.91v5
181 downloads
823 views

The characteristics of the culture vessel determine, to a large extent, the type of growth medium suitable for use. For example, most growth media for high cell density cultivation are designed for expensive bioreactors operating either in continuous or fed-batch...

["Biochemistry","Bioengineering","Biotechnology","Environmental Sciences","Microbiology"]
doi:10.7287/peerj.preprints.117v5
303 downloads
1,268 views

Sufficient quantities of cells of consistent characteristics are needed for studying biologicalprocesses (at the population level ) in many areas of applied microbiology. However, generating the requisite biomass by cell culture is usually the rate-limiting step...

["Biochemistry","Biotechnology","Environmental Sciences","Microbiology"]
doi:10.7287/peerj.preprints.115v6
66 downloads
377 views

Primary production due to photosynthesis results in daytime oxygen production across marine and freshwater ecosystems. However, a prevalent, globally-occurring nighttime spike in dissolved oxygen (DO) challenges our traditional assumption that oxygen production...

["Biochemistry","Ecology","Ecosystem Science","Environmental Sciences","Marine Biology"]
doi:10.7287/peerj.preprints.2935v2
184 downloads
478 views

In this review, we present a summary of how computer modeling has been used in the development of covalent modifier drugs. Covalent modifier drugs bind by forming a chemical bond with their target. This covalent binding can improve the selectivity of the drug for...

["Biochemistry","Bioinformatics","Biophysics","Pharmacology","Computational Science"]
doi:10.7287/peerj.preprints.2857v2
89 downloads
232 views

Robotic Labs, in which experiments are carried out entirely by robots, have the potential to provide a reproducible and transparent foundation for performing basic biomedical laboratory experiments. In this article, we investigate whether these labs are applicable...

["Biochemistry","Science Policy"]
doi:10.7287/peerj.preprints.2974v1
15 downloads
118 views

Movement in proteins requires energy. To this end, natural selection has selected phosphate as the principal energy currency in cells. On the other hand, depicting the state of transcription could come in the form of epigenetic markers, which are modifications...

["Biochemistry","Cell Biology","Computational Biology","Genetics","Molecular Biology"]
doi:10.7287/peerj.preprints.2966v1
12 downloads
116 views

A salivary gland salivation stimulating peptide was identified from the salivary glands of the migratory locust by its ability to stimulate cAMP production in the same tissue. The gene coding for this peptide has recently been shown to code for a precursor consisting...

["Agricultural Science","Biochemistry","Entomology","Neuroscience","Zoology"]
doi:10.7287/peerj.preprints.2940v1
34 downloads
249 views

12R-LOX over-expression has been reported in various pathologies such as psoriasis, proliferative dermatitis as well as pulmonary obstructive diseases indicating that this enzyme plays significant role in pathogenesis of inflammatory diseases. 12R-LOX, therefore,...

["Biochemistry","Molecular Biology"]
doi:10.7287/peerj.preprints.2906v1
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