Preprints (not yet peer-reviewed)

25 downloads
79 views

Background. Osteoarthritis is the leading cause of chronic joint pain, causing important productivity and economic losses. It is believed that peripheral and centralized sensitization play a role in the creation and maintenance of a chronic painful state. Different...

["Anaesthesiology and Pain Management","Pharmacology","Rheumatology","Translational Medicine"]
doi:10.7287/peerj.preprints.2704v1
107 downloads
104 views

Historically, handling insects usually involved their being killed as early studies used these organisms for work on genetics, physiology and/or pesticide bioassays. With the advancement of these research topics, the development of behavioral studies and the sensitivity...

["Agricultural Science","Animal Behavior","Entomology","Anaesthesiology and Pain Management"]
doi:10.7287/peerj.preprints.2571v1
37 downloads
119 views

Objectives: Use of clinical audits to assess and improve perioperative hypothermia management in client-owned dogs. Methods: Two clinical audits were performed. Audit 1: data were collected to determine the incidence and duration of perioperative hypothermia (defined...

["Veterinary Medicine","Anaesthesiology and Pain Management"]
doi:10.7287/peerj.preprints.2350v1
80 downloads
192 views

A 6-year-old female Shetland Sheepdog with a history of cardiorespiratory compromise during general anaesthesia was referred for ovariohysterectomy surgery. Clinical examination was unremarkable at presentation and physiologic parameters under general anaesthesia...

["Veterinary Medicine","Allergy and Clinical Immunology","Anaesthesiology and Pain Management","Emergency and Critical Care","Pharmacology"]
doi:10.7287/peerj.preprints.2275v1
68 downloads
146 views

Paclitaxel, a chemotherapeutic agent, causes neuropathic pain whose supraspinal pathophysiology is not fully understood. Dysregulation of sodium channel expression, studied mainly in the periphery and spinal cord level, contributes to the pathogenesis of neuropathic...

["Molecular Biology","Neuroscience","Anaesthesiology and Pain Management","Pharmacology"]
doi:10.7287/peerj.preprints.1936v1
75 downloads
194 views

Background. Medications are not exempt from adverse drug reactions (ADR) and how the physician perceives the risk of prescription drugs could influence their availability to report ADR and their prescription behavior. Methods. We assess the perception of risk and...

["Anaesthesiology and Pain Management","Pharmacology","Public Health","Science and Medical Education"]
doi:10.7287/peerj.preprints.1890v1
73 downloads
239 views

Valproate, an indirect γ-aminobutiric acid agonist has been successfully used in various painful conditions. Despite its frequent use, limited pre-clinical and clinical data exist about its analgesic effect. We tested valproate p.o. in increasing doses (10, 25,...

["Neuroscience","Anaesthesiology and Pain Management","Pharmacology"]
doi:10.7287/peerj.preprints.1613v1
310 downloads
424 views

Tramadol is used in both human and veterinary medicine to treat postoperative pain. The purpose of this study was to evaluate tramadol as a sole postoperative analgesic and to compare drug plasma concentration to clinical pain score. A high or low dose of tramadol...

["Anaesthesiology and Pain Management","Evidence Based Medicine","Pharmacology","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.1510v1
105 downloads
281 views

Spinal astrocyte activation contributes to the pathogenesis of paclitaxel-induced neuropathic pain (PINP) in animal models. We examined glial fibrillary acidic protein (GFAP; an astrocyte marker) immunoreactivity and gene expression of GFAP, glutamate transporters...

["Molecular Biology","Neuroscience","Anaesthesiology and Pain Management","Pharmacology"]
doi:10.7287/peerj.preprints.1246v2
1,814 downloads
743 views

Manual therapy has long been a component of physical rehabilitation programs, especially to treat those in pain. The mechanisms of manual therapy, however, are not fully understood, and it has been suggested that its pain modulatory effects are of neurophysiological...

["Neuroscience","Anaesthesiology and Pain Management","Anatomy and Physiology"]
doi:10.7287/peerj.preprints.996v2
586 downloads
334 views

["Anaesthesiology and Pain Management","Dermatology","Epidemiology"]
doi:10.7287/peerj.preprints.785v1
375 downloads
321 views

Aim Pain associated poor sleep quality has been reported among opioid dependent patients on methadone maintenance therapy (MMT) but objective pain data are lacking. This study aimed to investigate the rate of objective pain sensitivity and the relationship between...

["Anaesthesiology and Pain Management","Drugs and Devices","Internal Medicine","Nursing","Pharmacology"]
doi:10.7287/peerj.preprints.615v1
34 downloads
215 views

Background: While single-institution studies reported the indications and outcomes of tracheostomy in children with congenital heart disease (CHD), no national analyses have been performed. We sought to examine the indications, performance, outcomes, and resource...

["Anaesthesiology and Pain Management","Cardiology","Epidemiology","Pediatrics","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.465v1
77 downloads
315 views

Background: Do-not-resuscitate (DNR) orders are often active in patients with multiple comorbidities and a short natural life expectancy, but limited information exists as to how often these patients undergo high-risk operations and of the perioperative outcomes...

["Anaesthesiology and Pain Management","Emergency and Critical Care","Palliative Care","Public health","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.128v1
578 downloads
450 views

Involuntary movement during and after neuraxial anesthesia, such as spinal and epidural anesthesia, is rarely observed. In this report, we describe a case of myoclonus-like involuntary movement of the upper extremities in a patient undergoing a planned repeat cesarean...

["Anaesthesiology and Pain Management","Gynecology and Obstetrics","Neurology"]
doi:10.7287/peerj.preprints.101v1
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