Preprints (not yet peer-reviewed)

56 downloads
217 views

Two recent researches described the spread of East/Central/South African (ECSA) lineage of chikungunya virus (CHIKV) in the Northeastern and Southeastern Brazil (Charlys da Costa et al. 2017, Cunha et al. 2017) . Initial studies in Northern Brazil, as observed...

["Virology","Epidemiology","Infectious Diseases","Public Health","Translational Medicine"]
doi:10.7287/peerj.preprints.26707v1
51 downloads
109 views

Several studies that analyzed the burden of influenza during the 2009 pandemic found that excess mortality tended to wane or even disappear in equatorial regions, adding to evidence that suggests that seasonal influenza may have a lower impact in tropical settings....

["Epidemiology","Global Health","Infectious Diseases","Public Health","Translational Medicine"]
doi:10.7287/peerj.preprints.26705v1
39 downloads
136 views

Background: We established a glioma biobank at Beijing Tiantan Hospital in November, 2010.Specialized staffs have been trained to collect, store and manage the biobank in accordance with standard operating procedures. Methods: One hundred samples were selected...

["Neurology","Oncology","Translational Medicine"]
doi:10.7287/peerj.preprints.3478v1
194 downloads
263 views

Objective: To characterize the regional and national variation in prescribing patterns in the Medicare Part D program using machine learning and dimensional reduction visualization methods. Methods: Using publicly available Medicare Part D claims data, we identified...

["Bioinformatics","Health Policy","Translational Medicine","Data Science"]
doi:10.7287/peerj.preprints.3470v1
102 downloads
609 views

In translational medicine, the technology of RNA sequencing (RNA-seq) continues to prove powerful, and transforming the RNA-seq data into biological insights has become increasingly imperative. We present the Transcriptomics profiler for Easy Discovery (TED) toolkit,...

["Bioinformatics","Genomics","Translational Medicine","Computational Science","Data Science"]
doi:10.7287/peerj.preprints.3385v1
109 downloads
769 views

Background and purpose Oxidative stress is involved in normal and pathological functioning of skeletal muscle. Protection of myoblasts from oxidative stress may improve muscle contraction and delay aging. Here we studied the effect of R. coriaria sumac fruit extract...

["Cell Biology","Translational Medicine"]
doi:10.7287/peerj.preprints.3383v1
83 downloads
196 views

One of the great challenges in ecology and evolutionary biology is to explain disease, whether caused by infectious agents such as parasites and pathogens, or by the deterioration or transformation of cellular behavior and function, a prime example of the latter...

["Evolutionary Studies","Global Health","Public Health","Translational Medicine","Population Biology"]
doi:10.7287/peerj.preprints.3378v1
189 downloads
479 views

Background: Salvia officinalis (sage) is a native plant to the Mediterranean region and has been used for a long time in traditional medicine for various diseases. We investigated possible anti-diabetic, anti-inflammatory and anti-obesity effects of sage methanol...

["Diabetes and Endocrinology","Nutrition","Translational Medicine"]
doi:10.7287/peerj.preprints.3086v1
38 downloads
311 views

Background: Diabetes is one of the major risk factors for peripheral arterial disease. In patients in whom surgery cannot be performed, cell therapy may be an alternative treatment. Since time is crucial for these patients, we propose the use of allogenic mesenchymal...

["Surgery and Surgical Specialties","Translational Medicine"]
doi:10.7287/peerj.preprints.3075v1
97 downloads
362 views

Background: Traditionally, EBRT prostate treatments have been administered using three different techniques: three-dimensional conformal radiation therapy (3D-CRT), intensity modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT). These...

["Oncology","Radiology and Medical Imaging","Translational Medicine"]
doi:10.7287/peerj.preprints.2938v1
213 downloads
280 views

Background: The gamma analysis index (γ) is the most commonly used method to compare a calculated and measured dose distribution. A caveat to the clinical use of γ is that the formalism does have a sensitivity to noise present in either distribution. Monte Carlo...

["Oncology","Radiology and Medical Imaging","Translational Medicine"]
doi:10.7287/peerj.preprints.2904v1
361 downloads
562 views

This document summarizes a series of authoritative views on research data management, sharing and citation, developed in Expert Groups, Working Groups, and other activities organized through FORCE11 (http://force11.org), an international community of over 2,000...

["Translational Medicine","Science Policy","Human-Computer Interaction","Computational Science"]
doi:10.7287/peerj.preprints.2836v1
137 downloads
265 views

The “reproducibility crisis” has been a highly visible source of scientific controversy and dispute. Here, I propose and review several avenues for identifying and prioritizing research studies for the purpose of targeted validation. Of the various proposals discussed,...

["Bioinformatics","Evidence Based Medicine","Health Policy","Translational Medicine","Science Policy"]
doi:10.7287/peerj.preprints.2830v1
63 downloads
342 views

Background. Osteoarthritis is the leading cause of chronic joint pain, causing important productivity and economic losses. It is believed that peripheral and centralized sensitization play a role in the creation and maintenance of a chronic painful state. Different...

["Anesthesiology and Pain Management","Pharmacology","Rheumatology","Translational Medicine"]
doi:10.7287/peerj.preprints.2704v1
53 downloads
240 views

Context. The statistical analysis is an important part of the process of assessing the quality of randomized controlled trials, unfortunately it tends to be underestimated or even omitted by editors, in this sense, scales that cover this gap becomes necessary....

["Translational Medicine","Statistics"]
doi:10.7287/peerj.preprints.2609v1
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