Preprints (not yet peer-reviewed)

199 downloads
399 views

Bacteria and other microbes play a crucial role in human health and disease. Medicine and clinical microbiology have traditionally attempted to identify the etiological agents that causes disease, and how to eliminate them. Yet this traditional paradigm is becoming...

["Ecology","Evolutionary Studies","Genomics","Infectious Diseases","Translational Medicine"]
doi:10.7287/peerj.preprints.26969v2
561 downloads
709 views

“Open access” has become a central theme of journal reform in academic publishing. In this article, I examine the relationship between open access publishing and an important infrastructural element of a modern research enterprise, scientific literature text mining,...

["Bioinformatics","Evidence Based Medicine","Health Policy","Translational Medicine","Science Policy"]
doi:10.7287/peerj.preprints.2566v2
171 downloads
446 views

The “reproducibility crisis” has been a highly visible source of scientific controversy and dispute. Here, I propose and review several avenues for identifying and prioritizing research studies for the purpose of targeted validation. Of the various proposals discussed,...

["Bioinformatics","Evidence Based Medicine","Health Policy","Translational Medicine","Science Policy"]
doi:10.7287/peerj.preprints.2830v2
98 downloads
280 views

Two recent researches described the spread of East/Central/South African (ECSA) lineage of chikungunya virus (CHIKV) in the Northeastern and Southeastern Brazil (Charlys da Costa et al. 2017, Cunha et al. 2017) . Initial studies in Northern Brazil, as observed...

["Virology","Epidemiology","Infectious Diseases","Public Health","Translational Medicine"]
doi:10.7287/peerj.preprints.26707v1
88 downloads
156 views

Several studies that analyzed the burden of influenza during the 2009 pandemic found that excess mortality tended to wane or even disappear in equatorial regions, adding to evidence that suggests that seasonal influenza may have a lower impact in tropical settings....

["Epidemiology","Global Health","Infectious Diseases","Public Health","Translational Medicine"]
doi:10.7287/peerj.preprints.26705v1
60 downloads
168 views

Background: We established a glioma biobank at Beijing Tiantan Hospital in November, 2010.Specialized staffs have been trained to collect, store and manage the biobank in accordance with standard operating procedures. Methods: One hundred samples were selected...

["Neurology","Oncology","Translational Medicine"]
doi:10.7287/peerj.preprints.3478v1
303 downloads
291 views

Objective: To characterize the regional and national variation in prescribing patterns in the Medicare Part D program using machine learning and dimensional reduction visualization methods. Methods: Using publicly available Medicare Part D claims data, we identified...

["Bioinformatics","Health Policy","Translational Medicine","Data Science"]
doi:10.7287/peerj.preprints.3470v1
149 downloads
765 views

In translational medicine, the technology of RNA sequencing (RNA-seq) continues to prove powerful, and transforming the RNA-seq data into biological insights has become increasingly imperative. We present the Transcriptomics profiler for Easy Discovery (TED) toolkit,...

["Bioinformatics","Genomics","Translational Medicine","Computational Science","Data Science"]
doi:10.7287/peerj.preprints.3385v1
147 downloads
990 views

Background and purpose Oxidative stress is involved in normal and pathological functioning of skeletal muscle. Protection of myoblasts from oxidative stress may improve muscle contraction and delay aging. Here we studied the effect of R. coriaria sumac fruit extract...

["Cell Biology","Translational Medicine"]
doi:10.7287/peerj.preprints.3383v1
98 downloads
223 views

One of the great challenges in ecology and evolutionary biology is to explain disease, whether caused by infectious agents such as parasites and pathogens, or by the deterioration or transformation of cellular behavior and function, a prime example of the latter...

["Evolutionary Studies","Global Health","Public Health","Translational Medicine","Population Biology"]
doi:10.7287/peerj.preprints.3378v1
256 downloads
619 views

Background: Salvia officinalis (sage) is a native plant to the Mediterranean region and has been used for a long time in traditional medicine for various diseases. We investigated possible anti-diabetic, anti-inflammatory and anti-obesity effects of sage methanol...

["Diabetes and Endocrinology","Nutrition","Translational Medicine"]
doi:10.7287/peerj.preprints.3086v1
46 downloads
403 views

Background: Diabetes is one of the major risk factors for peripheral arterial disease. In patients in whom surgery cannot be performed, cell therapy may be an alternative treatment. Since time is crucial for these patients, we propose the use of allogenic mesenchymal...

["Surgery and Surgical Specialties","Translational Medicine"]
doi:10.7287/peerj.preprints.3075v1
122 downloads
371 views

Background: Traditionally, EBRT prostate treatments have been administered using three different techniques: three-dimensional conformal radiation therapy (3D-CRT), intensity modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT). These...

["Oncology","Radiology and Medical Imaging","Translational Medicine"]
doi:10.7287/peerj.preprints.2938v1
268 downloads
308 views

Background: The gamma analysis index (γ) is the most commonly used method to compare a calculated and measured dose distribution. A caveat to the clinical use of γ is that the formalism does have a sensitivity to noise present in either distribution. Monte Carlo...

["Oncology","Radiology and Medical Imaging","Translational Medicine"]
doi:10.7287/peerj.preprints.2904v1
381 downloads
643 views

This document summarizes a series of authoritative views on research data management, sharing and citation, developed in Expert Groups, Working Groups, and other activities organized through FORCE11 (http://force11.org), an international community of over 2,000...

["Translational Medicine","Science Policy","Human-Computer Interaction","Computational Science"]
doi:10.7287/peerj.preprints.2836v1
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