Preprints (not yet peer-reviewed)

474 downloads
1,992 views

Horseshoe crabs have been integral to the safe production of vaccines and injectable medications for the past forty years. The bleeding of live horseshoe crabs, a process that leaves thousands dead annually, is an ecologically unsustainable practice for all four...

["Conservation Biology","Drugs and Devices","Pharmacology","Synthetic Biology","Environmental Impacts"]
doi:10.7287/peerj.preprints.26922v1
218 downloads
214 views

Background. Beyond its traditional uses in the Balkan area, Sideritis scardica (known as Greek mountain tea, Lamiaceae) is currently extensively investigated for its pharmacological activity in the central nervous system. Antidepressant, psychostimulating, cognition-enhancing...

["Cognitive Disorders","Drugs and Devices","Pharmacology"]
doi:10.7287/peerj.preprints.3483v1
70 downloads
382 views

Previously, we revealed that several kampo medicines that are used for patients with excess and/or medium patterns [kakkonto (TJ-1), shosaikoto (TJ-9), hangeshashinto (TJ-14), and orento (TJ-120)] reduced prostaglandin (PG)E<2 levels using LPS-treated human gingival...

["Cell Biology","Dentistry","Pharmacology"]
doi:10.7287/peerj.preprints.3227v2
46 downloads
165 views

Background. Microdialysis is a valued method to study the pharmacokinetics of drug distribution from an injection site or to a tumor site. The objective of this study was to assess the feasibility of prolonged use of subcutaneously implanted microdialysis catheters...

["Drugs and Devices","Oncology","Pharmacology"]
doi:10.7287/peerj.preprints.3324v1
112 downloads
221 views

Backgroud. Mercuric sulfide (HgS) has been used in traditional medicines for thousands of years, such as cinnabar, Zuotai and so on. Increasing research supports that HgS is different from mercury chloride (HgCl2) and methylmercury (MeHg) in toxicity and pharmacology,...

["Toxicology","Pharmacology"]
doi:10.7287/peerj.preprints.3308v1
57 downloads
441 views

Background: Drugs for dementia have been available in England from 1997. Since their launch, there have been several changes to national guidelines and initiatives that may have influenced prescribing. These include changes in National Institute for health and...

["Neuroscience","Epidemiology","Pharmacology","Statistics"]
doi:10.7287/peerj.preprints.3238v1
248 downloads
410 views

The classical way of defining enzyme inhibition has obscured the distinction between inhibitory effect and the inhibitor binding constant. This article examines the relationship between the simple binding curve used to define biomolecular interactions and the standard...

["Biochemistry","Computational Biology","Mathematical Biology","Drugs and Devices","Pharmacology"]
doi:10.7287/peerj.preprints.3094v1
173 downloads
434 views

Abstract Ginsenoside Rk1 (G-Rk1) is one of the unique components created by processing ginseng at high temperature, in particular of Sun Ginseng (SG). The aim of our study was to systematically review the pharmacological effects of G-Rk1.we conducted our search...

["Plant Science","Evidence Based Medicine","Pharmacology"]
doi:10.7287/peerj.preprints.3013v1
533 downloads
608 views

In this review, we present a summary of how computer modeling has been used in the development of covalent modifier drugs. Covalent modifier drugs bind by forming a chemical bond with their target. This covalent binding can improve the selectivity of the drug for...

["Biochemistry","Bioinformatics","Biophysics","Pharmacology","Computational Science"]
doi:10.7287/peerj.preprints.2857v2
58 downloads
227 views

Propofol is an intravenous anesthetic commonly used due to its favorable pharmacokinetic and pharmacodynamic profile. There are discrepancies in the literature about the most appropriate sample for determining propofol concentrations. Although plasma has been used...

["Veterinary Medicine","Pharmacology"]
doi:10.7287/peerj.preprints.2885v1
71 downloads
383 views

Background. Osteoarthritis is the leading cause of chronic joint pain, causing important productivity and economic losses. It is believed that peripheral and centralized sensitization play a role in the creation and maintenance of a chronic painful state. Different...

["Anesthesiology and Pain Management","Pharmacology","Rheumatology","Translational Medicine"]
doi:10.7287/peerj.preprints.2704v1
36 downloads
348 views

The biological activities of quinoxalone, a novel small molecular substance isolated from the broth of the myxobacterium Stigmatella eracta WXNXJ-B, was investigated. This study was designed to determine the anti-proliferative, apoptotic property of quinoxalone,...

["Biotechnology","Microbiology","Pharmacology"]
doi:10.7287/peerj.preprints.2703v1
40 downloads
262 views

Maximakinin (MK), an amphibian peptide possessing the C-terminal sequence of bradykinin (BK), is a BK B2 receptor (B2R) agonist eliciting prolonged signaling. We reinvestigated this 19-mer for species-specific pharmacologic profile, in vivo confirmation of resistance...

["Cardiology","Pharmacology"]
doi:10.7287/peerj.preprints.2641v1
74 downloads
474 views

Benign prostatic hyperplasia is a common disease in men aged over 50 years old, with an incidence increasing to more than 80% over the age of 70, that is increasingly going to attract pharmaceutical interest. Within conventional therapies, such as α-adrenoreceptor...

["Computational Biology","Pharmacology"]
doi:10.7287/peerj.preprints.2543v1
81 downloads
336 views

The study of subjective, first-person experience is a topic with both philosophical and practical implications. In this article, I discuss the value of collecting a critical mass of prose or verbal descriptions of introspectively determined, subjective effects...

["Toxicology","Evidence Based Medicine","Neurology","Pharmacology","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.2424v1
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