Preprints (not yet peer-reviewed)

240 downloads
578 views

Lesion of the dopaminergic neurons of the nigrostriatal system is a key feature of Parkinson's disease (PD). Alpha-synuclein is a protein that is a major component of Lewy bodies, histopathological hallmarks of PD, and is involved in regulation of dopamine (DA)...

["Developmental Biology","Neuroscience","Neurology","Pathology"]
doi:10.7287/peerj.preprints.26547v2
82 downloads
147 views

Background and Objective: Clinical and experimental observations emphasize the role of inflammation as a direct risk factor for stroke. To better characterize the inflammation, we have conducted a detailed histological analysis of the inflammatory cell population...

["Neuroscience","Pathology"]
doi:10.7287/peerj.preprints.26510v1
252 downloads
434 views

The compound eye is the primary visual system in crustaceans. Although the histological structure and histochemical characteristics of compound eyes of some insect and crab species are now well understood, no such studies have been undertaken in the whiteleg shrimp...

["Aquaculture, Fisheries and Fish Science","Anatomy and Physiology","Ophthalmology","Pathology","Histology"]
doi:10.7287/peerj.preprints.3453v1
82 downloads
505 views

Small interference RNA has been widely used to suppress gene expression. Three different short-hairpin RNAs (shRNAs) against dopamine D1 receptor (Drd1), driven by mouse U6 promoter in self-complementary AAV8 vector (scAAV8), were used to silence mouse striatal...

["Neuroscience","Neurology","Pathology"]
doi:10.7287/peerj.preprints.3117v1
85 downloads
356 views

Increased levels of long noncoding RNA H19 (H19) have been observed in many inflammatory and organ fibrosis diseases including ulcerative colitis, osteoarthritis, liver fibrosis, renal fibrosis and pulmonary fibrosis. However, the role of H19 in bovine mastitis...

["Cell Biology","Veterinary Medicine","Pathology"]
doi:10.7287/peerj.preprints.3089v1
48 downloads
251 views

The identification of Parrot bornaviruses in psittacine birds with proventricular dilatation disease (PDD) has not been sufficient to explain the pathogenesis of this fatal disease since not all infected birds develop clinical signs. One hypothesis suggests that...

["Veterinary Medicine","Virology","Pathology"]
doi:10.7287/peerj.preprints.2852v1
190 downloads
283 views

Background: Electrolytic ablation and electroporation based ablation are minimally invasive, non-thermal surgical technologies that employ electrical currents and electric fields to ablate undesirable cells in a volume of tissue. In this study we explore the attributes...

["Bioengineering","Biophysics","Oncology","Pathology","Histology"]
doi:10.7287/peerj.preprints.2549v1
573 downloads
649 views

Visual medical analogies have been utilized by multiple medical disciplines for decades. Despite misgivings that some might have about such analogies, they act as excellent learning aids and will undoubtedly remain useful for decades to come. The microscope from...

["Pathology"]
doi:10.7287/peerj.preprints.2147v2
146 downloads
372 views

N-Acetyl-p-Aminophenol (APAP), aka acetaminophen, is the most commonly used over-the counter analgesic and antipyretic medication. However, its overdose leads to both liver and kidney damage. APAP-induced toxicity is considered as one of the primary causes of acute...

["Food Science and Technology","Neuroscience","Toxicology","Pathology","Pharmacology"]
doi:10.7287/peerj.preprints.2063v1
107 downloads
368 views

Bladder Cancer is one of the most frequent human cancer which develops on two tracks, papillary and non-papillary that correspond to clinically different forms of the disease. Most bladder cancers are chemically induced with tobacco smoking being the leading risk...

["Genomics","Molecular Biology","Pathology","Urology"]
doi:10.7287/peerj.preprints.1778v1
274 downloads
265 views

Phenotypic characterization of cellular responses in equine infectious encephalitides has had limited description of both peripheral and resident cell populations in central nervous system (CNS) tissues due to limited species-specific reagents that react with formalin-fixed,...

["Veterinary Medicine","Infectious Diseases","Pathology","Histology"]
doi:10.7287/peerj.preprints.1641v1
379 downloads
713 views

Purpose. Type 2 diabetes is the leading cause of end stage renal disease in the United States. Atherosclerotic renal artery stenosis is commonly observed in diabetic patients and impacts the rate of renal and cardiovascular disease progression. We hypothesized...

["Cardiology","Diabetes and Endocrinology","Nephrology","Pathology","Translational Medicine"]
doi:10.7287/peerj.preprints.1323v2
1,222 downloads
827 views

Whether obesity is a disease or a risk factor of chronic diseases including diabetes and fatty liver remains debating. We report here that a high-fat diet (HFD) alone or HFD and intramuscular injection of mice with a high dose (1.2 mg/kg) of lipopolysaccharide...

["Diabetes and Endocrinology","Pathology","Pharmacology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.1229v1
97 downloads
367 views

Background: In a region of Caribbean states with limited human and financial resources institutions of higher education must use the technology available to reach its students across the region and allow professionals in the Biomedical Sciences to teach, interact...

["Anatomy and Physiology","Pathology","Science and Medical Education"]
doi:10.7287/peerj.preprints.1104v1
181 downloads
530 views

Rothschild (2013) suggested that many of the facial and postcranial scars in tyrannosaurid specimens are in fact caused by claws of the other tyrannosaurids. However, the evidences suggested by Rothschild (2013) are very weak. Tooth marks can have very different...

["Animal Behavior","Ecosystem Science","Paleontology","Zoology","Pathology"]
doi:10.7287/peerj.preprints.980v1
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