Preprints (not yet peer-reviewed)

17 downloads
67 views

Clinical bioinformatics, translational bioinformatics and personalised medicine are connected by the common task of analysing and integrating clinical data and results, in order to find important biomarkers related to pathologies and facilitate their prediction,...

["Bioinformatics","Computational Biology","Pathology","Statistics","Data Science"]
doi:10.7287/peerj.preprints.27398v1
258 downloads
614 views

Lesion of the dopaminergic neurons of the nigrostriatal system is a key feature of Parkinson's disease (PD). Alpha-synuclein is a protein that is a major component of Lewy bodies, histopathological hallmarks of PD, and is involved in regulation of dopamine (DA)...

["Developmental Biology","Neuroscience","Neurology","Pathology"]
doi:10.7287/peerj.preprints.26547v2
95 downloads
159 views

Background and Objective: Clinical and experimental observations emphasize the role of inflammation as a direct risk factor for stroke. To better characterize the inflammation, we have conducted a detailed histological analysis of the inflammatory cell population...

["Neuroscience","Pathology"]
doi:10.7287/peerj.preprints.26510v1
284 downloads
450 views

The compound eye is the primary visual system in crustaceans. Although the histological structure and histochemical characteristics of compound eyes of some insect and crab species are now well understood, no such studies have been undertaken in the whiteleg shrimp...

["Aquaculture, Fisheries and Fish Science","Anatomy and Physiology","Ophthalmology","Pathology","Histology"]
doi:10.7287/peerj.preprints.3453v1
86 downloads
518 views

Small interference RNA has been widely used to suppress gene expression. Three different short-hairpin RNAs (shRNAs) against dopamine D1 receptor (Drd1), driven by mouse U6 promoter in self-complementary AAV8 vector (scAAV8), were used to silence mouse striatal...

["Neuroscience","Neurology","Pathology"]
doi:10.7287/peerj.preprints.3117v1
90 downloads
366 views

Increased levels of long noncoding RNA H19 (H19) have been observed in many inflammatory and organ fibrosis diseases including ulcerative colitis, osteoarthritis, liver fibrosis, renal fibrosis and pulmonary fibrosis. However, the role of H19 in bovine mastitis...

["Cell Biology","Veterinary Medicine","Pathology"]
doi:10.7287/peerj.preprints.3089v1
50 downloads
263 views

The identification of Parrot bornaviruses in psittacine birds with proventricular dilatation disease (PDD) has not been sufficient to explain the pathogenesis of this fatal disease since not all infected birds develop clinical signs. One hypothesis suggests that...

["Veterinary Medicine","Virology","Pathology"]
doi:10.7287/peerj.preprints.2852v1
195 downloads
292 views

Background: Electrolytic ablation and electroporation based ablation are minimally invasive, non-thermal surgical technologies that employ electrical currents and electric fields to ablate undesirable cells in a volume of tissue. In this study we explore the attributes...

["Bioengineering","Biophysics","Oncology","Pathology","Histology"]
doi:10.7287/peerj.preprints.2549v1
653 downloads
670 views

Visual medical analogies have been utilized by multiple medical disciplines for decades. Despite misgivings that some might have about such analogies, they act as excellent learning aids and will undoubtedly remain useful for decades to come. The microscope from...

["Pathology"]
doi:10.7287/peerj.preprints.2147v2
153 downloads
378 views

N-Acetyl-p-Aminophenol (APAP), aka acetaminophen, is the most commonly used over-the counter analgesic and antipyretic medication. However, its overdose leads to both liver and kidney damage. APAP-induced toxicity is considered as one of the primary causes of acute...

["Food Science and Technology","Neuroscience","Toxicology","Pathology","Pharmacology"]
doi:10.7287/peerj.preprints.2063v1
113 downloads
377 views

Bladder Cancer is one of the most frequent human cancer which develops on two tracks, papillary and non-papillary that correspond to clinically different forms of the disease. Most bladder cancers are chemically induced with tobacco smoking being the leading risk...

["Genomics","Molecular Biology","Pathology","Urology"]
doi:10.7287/peerj.preprints.1778v1
308 downloads
272 views

Phenotypic characterization of cellular responses in equine infectious encephalitides has had limited description of both peripheral and resident cell populations in central nervous system (CNS) tissues due to limited species-specific reagents that react with formalin-fixed,...

["Veterinary Medicine","Infectious Diseases","Pathology","Histology"]
doi:10.7287/peerj.preprints.1641v1
392 downloads
727 views

Purpose. Type 2 diabetes is the leading cause of end stage renal disease in the United States. Atherosclerotic renal artery stenosis is commonly observed in diabetic patients and impacts the rate of renal and cardiovascular disease progression. We hypothesized...

["Cardiology","Diabetes and Endocrinology","Nephrology","Pathology","Translational Medicine"]
doi:10.7287/peerj.preprints.1323v2
1,286 downloads
839 views

Whether obesity is a disease or a risk factor of chronic diseases including diabetes and fatty liver remains debating. We report here that a high-fat diet (HFD) alone or HFD and intramuscular injection of mice with a high dose (1.2 mg/kg) of lipopolysaccharide...

["Diabetes and Endocrinology","Pathology","Pharmacology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.1229v1
102 downloads
381 views

Background: In a region of Caribbean states with limited human and financial resources institutions of higher education must use the technology available to reach its students across the region and allow professionals in the Biomedical Sciences to teach, interact...

["Anatomy and Physiology","Pathology","Science and Medical Education"]
doi:10.7287/peerj.preprints.1104v1
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