Preprints (not yet peer-reviewed)

492 downloads
1,142 views

Background: Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulatory technique that has shown encouraging results regarding performance improvement of normal subjects in tests of executive functions. Moreover, when applied repeatedly in...

["Clinical Trials","Neurology","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.1610v2
125 downloads
134 views

Microglia are highly ramified brain phagocytes that are finely tuned to surrounding neuronal and glial activity. Combined, microglia morphology, dynamic process movement, phagocytic, and neuroinflammatory responses aid in the detection of changed neuronal function,...

["Neuroscience","Neurology"]
doi:10.7287/peerj.preprints.26937v1
242 downloads
580 views

Lesion of the dopaminergic neurons of the nigrostriatal system is a key feature of Parkinson's disease (PD). Alpha-synuclein is a protein that is a major component of Lewy bodies, histopathological hallmarks of PD, and is involved in regulation of dopamine (DA)...

["Developmental Biology","Neuroscience","Neurology","Pathology"]
doi:10.7287/peerj.preprints.26547v2
65 downloads
182 views

Background: We established a glioma biobank at Beijing Tiantan Hospital in November, 2010.Specialized staffs have been trained to collect, store and manage the biobank in accordance with standard operating procedures. Methods: One hundred samples were selected...

["Neurology","Oncology","Translational Medicine"]
doi:10.7287/peerj.preprints.3478v1
355 downloads
454 views

We propose a new hypothesis about the physical-chemical mechanisms of nerve conduction in myelinated nerves, tending to bridge the theoretical gap existing to date between the basic neuronal activity and its adaptation to myelination. All the considerations imply...

["Biochemistry","Neuroscience","Neurology"]
doi:10.7287/peerj.preprints.3409v1
82 downloads
506 views

Small interference RNA has been widely used to suppress gene expression. Three different short-hairpin RNAs (shRNAs) against dopamine D1 receptor (Drd1), driven by mouse U6 promoter in self-complementary AAV8 vector (scAAV8), were used to silence mouse striatal...

["Neuroscience","Neurology","Pathology"]
doi:10.7287/peerj.preprints.3117v1
122 downloads
283 views

A scientific theory or hypothesis is presented, in which mineral particles may play a pivotal role in the prion disease transmissible spongiform encephalopathy (TSE), and possibly also in other protein-misfolding diseases. Montmorillonite clay (Mte) and other minerals...

["Cell Biology","Molecular Biology","Infectious Diseases","Neurology"]
doi:10.7287/peerj.preprints.2982v1
202 downloads
1,037 views

The involvement of the right and left hemispheres in mediating language functions has been measured in a variety of ways over the centuries since the relative dominance of the left hemisphere was first known. Functional magnetic resonance imaging (fMRI) presents...

["Neuroscience","Neurology","Psychiatry and Psychology","Radiology and Medical Imaging"]
doi:10.7287/peerj.preprints.2962v2
99 downloads
228 views

The search for a universal definition of death is a relatively new objective in human history, framed by complex biological, technological, and socio-political factors. While it is widely understood that “life” and “death” describe inverse states of being, what...

["Health Policy","Neurology","Ethical Issues","Legal Issues"]
doi:10.7287/peerj.preprints.2890v1
131 downloads
353 views

Walking velocity is an important control variable in gait disorders due to sensory or cerebellar disfunction. Non-preferred walking speeds are closely linked to a higher risk of falls. A compensation strategy of patients to avoid these speed sectors can be assumed....

["Bioinformatics","Anatomy and Physiology","Neurology"]
doi:10.7287/peerj.preprints.2545v1
99 downloads
355 views

The study of subjective, first-person experience is a topic with both philosophical and practical implications. In this article, I discuss the value of collecting a critical mass of prose or verbal descriptions of introspectively determined, subjective effects...

["Toxicology","Evidence Based Medicine","Neurology","Pharmacology","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.2424v1
739 downloads
613 views

Background: Astrocytomas and oligodendrogliomas are two types of primary Central nervous system (CNS) tumors. Because of the cytoarchitectural variability and lacking of accurate differential diagnosis biomarkers, distinguishing between these neoplasms remains...

["Neuroscience","Neurology"]
doi:10.7287/peerj.preprints.2179v1
84 downloads
354 views

The autonomy of individuals is linked to the achievement of instrumental activities of daily living that require complex behavior. In elderly, the assessment of autonomy is usually based on questionnaires that have strong subjective constraints. Considering this...

["Neurology","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.2111v1
153 downloads
1,037 views

The objective of this pilot study was to evaluate the feasibility of Flash Visual Evoked Potentials (FVEPs) testing in birds of prey in a clinical setting and to describe the protocol and the baseline data for normal vision in this species. FVEP recordings were...

["Neuroscience","Veterinary Medicine","Zoology","Neurology"]
doi:10.7287/peerj.preprints.1875v2
354 downloads
512 views

Mild traumatic brain injury typically involves temporary impairment of neurological function. Previous studies used the water pressure or rotational injury for designing the device to make a rat mild traumatic brain injury model. The objective of this study was...

["Neuroscience","Neurology"]
doi:10.7287/peerj.preprints.2037v1
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