Preprints (not yet peer-reviewed)

107 downloads
165 views

Both animal hibernation (heterothermy) and human renal osteodystrophy are characterized by high levels of serum parathyroid hormone. To test the hypothesis of hibernation in an extinct human species, we examined the hominin skeletal collection from Sima de los...

["Anthropology","Paleontology","Anatomy and Physiology","Nephrology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.27370v1
51 downloads
115 views

Background. Methylmalonic acidemia is a rare inborn error of metabolism caused by mutations in methylmalonyl−CoA mutase (MUT) gene. As intermediate of propionate metabolism, MUT converts methylmalonyl−CoA into succinyl−CoA, which enters the Krebs cycle. Downstream...

["Biochemistry","Bioinformatics","Biotechnology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.27335v1
51 downloads
160 views

Characterized by high blood glucose concentration, resistance of cells to glucose uptake and reduced insulin sensitivity, Type II diabetes is a major health problem afflicting both developing and developed countries in increasing extent as populations around the...

["Biochemistry","Cell Biology","Diabetes and Endocrinology","Internal Medicine","Metabolic Sciences"]
doi:10.7287/peerj.preprints.27024v1
159 downloads
586 views

Period of starvation is regarded as a sound practice in aquaculture prior to handling, transportation and harvest, to minimise impacts on welfare and ensure proper hygiene after harvest. However, documentation of welfare issues such as stress following starvation...

["Aquaculture, Fisheries and Fish Science","Veterinary Medicine","Metabolic Sciences"]
doi:10.7287/peerj.preprints.2837v1
109 downloads
346 views

Major risk factors for neurodegenerative diseases share brain hypometabolism as one common outcome. In turn, many neurodegenerative pathologies result in brain hypometabolism; both epilepsy and Alzheimer's disease are characterised by disruptions in glucose metabolism....

["Neuroscience","Metabolic Sciences"]
doi:10.7287/peerj.preprints.2521v1
36 downloads
232 views

Here we present a single working model that attempts at reconciliation of biological systems. To do this we recognize and emphasize a universal theme of all biological systems: a need for resources. That is, we consider the dynamics of resource allocation as a...

["Biochemistry","Cell Biology","Mathematical Biology","Anatomy and Physiology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.2503v1
888 downloads
1,207 views

“Omics” studies generate long lists of genes, proteins, metabolites or other features which can be difficult to decipher. Feature set enrichment analysis utilizing annotated groups/classes of features (such as pathways, gene ontology terms or gene/metabolic modules)...

["Bioinformatics","Immunology","Statistics","Metabolic Sciences","Computational Science"]
doi:10.7287/peerj.preprints.2420v1
68 downloads
283 views

Background. White adipose tissue (WAT) is a complex, disperse, multifunctional organ which contains adipocytes, and a large proportion of fat, but also other cell types, active in defence, regeneration and signalling functions. Studies with adipocytes often require...

["Cell Biology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.2371v1
202 downloads
298 views

It is shown that the mass, metabolism and length explanation (MMLE) can simultaneously compute an animal’s body mass and BMR given its characteristic length using data for humans. MMLE was advanced in 1984 to explain the relationship between metabolic rate and...

["Mathematical Biology","Anatomy and Physiology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.2182v1
680 downloads
569 views

Nascent, burgeoning, youngest, ‘connecting link between genotype and phenotype’ are just some of the phrases associated with this ‘omics’ where small molecules (metabolites with molecular weight < 2000 Daltons) are studied in biological systems, i.e., metabolomics....

["Bioinformatics","Computational Biology","Plant Science","Metabolic Sciences","Computational Science"]
doi:10.7287/peerj.preprints.2002v1
333 downloads
547 views

The digestive tract of mammals and other animals is colonized by trillions of metabolically active microorganisms. Changes in the gut microbiota have been associated with obesity in both humans and laboratory animals. Dietary modifications can often modulate the...

["Bioinformatics","Food Science and Technology","Microbiology","Nutrition","Metabolic Sciences"]
doi:10.7287/peerj.preprints.1458v1
1,287 downloads
839 views

Whether obesity is a disease or a risk factor of chronic diseases including diabetes and fatty liver remains debating. We report here that a high-fat diet (HFD) alone or HFD and intramuscular injection of mice with a high dose (1.2 mg/kg) of lipopolysaccharide...

["Diabetes and Endocrinology","Pathology","Pharmacology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.1229v1
128 downloads
731 views

It is unclear whether the adipokine chemerin has pro- or anti-inflammatory properties, plays any role in the aetiology of obesity or type 2 diabetes, or whether agonists or antagonists of the chemerin receptor CMKLR1 have potential in the treatment of these diseases....

["Diabetes and Endocrinology","Pharmacology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.643v1
63 downloads
306 views

Kv1 channels are shaker-related potassium channels that influence insulin sensitivity. Kv1.3 -/- mice are protected from diet-induced insulin resistance and some studies suggest that Kv1.3 inhibitors provide similar protection. However, it is unclear whether blockade...

["Biochemistry","Diabetes and Endocrinology","Pharmacology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.498v1
443 downloads
556 views

Metabolic dysfunction in skeletal muscle is a major contributor to the development of type 2 diabetes. Endurance exercise training has long been established as an effective means to directly restore skeletal muscle glucose and lipid uptake and metabolism. However,...

["Molecular Biology","Diabetes and Endocrinology","Kinesiology","Metabolic Sciences"]
doi:10.7287/peerj.preprints.410v1
What is a PeerJ Preprint?

A PeerJ Preprint is a draft of an article, abstract, or poster that has not yet been peer-reviewed for formal publication. Submit a draft, incomplete, or final version of your work for free.

Submissions today can be approved by Editorial Staff and online in 24 hours.

Establish precedent. Solicit feedback. Publish updates.

Refine by manuscript type

Top subject areas - Preprints

Top subject areas - People

View all subject areas