Preprints (not yet peer-reviewed)

176 downloads
409 views

Background. Ebola Virus Disease (EVD) is a highly infectious disease that has produced over 25,000 cases in the past 50 years. While many past outbreaks resulted in relatively few cases, the 2014 outbreak in West Africa was the most deadly occurrence of EVD to...

["Epidemiology","Infectious Diseases","Statistics"]
doi:10.7287/peerj.preprints.3021v2
195 downloads
392 views

Bacteria and other microbes play a crucial role in human health and disease. Medicine and clinical microbiology have traditionally attempted to identify the etiological agents that causes disease, and how to eliminate them. Yet this traditional paradigm is becoming...

["Ecology","Evolutionary Studies","Genomics","Infectious Diseases","Translational Medicine"]
doi:10.7287/peerj.preprints.26969v2
456 downloads
1,246 views

Low-cost Illumina sequencing of clinically-important bacterial pathogens has generated thousands of publicly available genomic datasets. Analyzing these genomes and extracting relevant information for each pathogen and the associated clinical phenotypes requires...

["Bioinformatics","Genomics","Infectious Diseases","Public Health"]
doi:10.7287/peerj.preprints.26890v2
279 downloads
658 views

Klebsiella pneumoniae is an opportunistic bacterial pathogen known for its high frequency and diversity of antimicrobial resistance (AMR) genes. In addition to being a significant clinical problem in its own right, K. pneumoniae is the species within which several...

["Ecology","Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.26852v1
98 downloads
280 views

Two recent researches described the spread of East/Central/South African (ECSA) lineage of chikungunya virus (CHIKV) in the Northeastern and Southeastern Brazil (Charlys da Costa et al. 2017, Cunha et al. 2017) . Initial studies in Northern Brazil, as observed...

["Virology","Epidemiology","Infectious Diseases","Public Health","Translational Medicine"]
doi:10.7287/peerj.preprints.26707v1
88 downloads
156 views

Several studies that analyzed the burden of influenza during the 2009 pandemic found that excess mortality tended to wane or even disappear in equatorial regions, adding to evidence that suggests that seasonal influenza may have a lower impact in tropical settings....

["Epidemiology","Global Health","Infectious Diseases","Public Health","Translational Medicine"]
doi:10.7287/peerj.preprints.26705v1
76 downloads
86 views

Background. The pathogenic role of S. aureus as causative agent of serious infections and food poisoning is on the increase. However, there are few reports on comprehensive analyses of toxins and staphylococcal enterotoxin (SE) genes in S. aureus in Africa. This...

["Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.26535v1
79 downloads
280 views

Background. Candida albicans is a commensal fungus that inhabits the oral mucosal surface and causes oral and systemic candidiasis. Oral candidiasis most commonly occurs in patients with AIDS, denture wearers and newborn children. Systemic candidiasis occurs mainly...

["Microbiology","Dentistry","Infectious Diseases","Women's Health"]
doi:10.7287/peerj.preprints.26526v1
127 downloads
140 views

Some marine microparasitic pathogens can survive several months outside the host in the water column to make contact with hosts or to be absorbed or filtered by hosts. Once inside, pathogens invade the host if they find suitable conditions for reproduction within...

["Ecology","Marine Biology","Mathematical Biology","Parasitology","Infectious Diseases"]
doi:10.7287/peerj.preprints.26454v2
136 downloads
248 views

Setting Seven public tuberculosis (TB) units in Kampala, Uganda, where Uganda’s national TB program recently introduced household contact investigation, as recommended by 2012 guidelines from WHO. Objective To apply a cascade analysis to implementation of household...

["Epidemiology","Global Health","Infectious Diseases","Public Health","Respiratory Medicine"]
doi:10.7287/peerj.preprints.3313v1
61 downloads
338 views

Bacterial surfaces are complex, built of from membranes, peptide-glycans and, importantly, proteins. The proteins play crucial roles as the key regulator of how the bacterium interacts with its environment. A full catalog of the motifs in coiled-coil proteins and...

["Bioinformatics","Infectious Diseases","Data Science"]
doi:10.7287/peerj.preprints.3118v2
117 downloads
289 views

Background. Antimicrobial drugs in veterinary medical practice are primarily prescribed for the purposes of maintaining or improving health and increasing productivity. However, their value is being eroded by antimicrobial resistance (AMR). Indiscriminate use of...

["Veterinary Medicine","Epidemiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.3253v1
65 downloads
323 views

Background. Parkinson’s disease (PD) is a disorder characterized by dopaminergic neuron programmed cell death. The etiology of PD remains uncertain—some cases are due to selected genes associated with familial heredity, others are due to environmental exposure...

["Microbiology","Neuroscience","Infectious Diseases"]
doi:10.7287/peerj.preprints.3152v1
298 downloads
2,628 views

Objective: In this study the main aspects of influenza transmission via fine and ultrafine bioaerosols were considered. Here, we aimed to estimate the impact of the different environment conditions on the deposition rate of the infectious bioaerosols in the respiratory...

["Epidemiology","Global Health","Infectious Diseases","Public Health","Respiratory Medicine"]
doi:10.7287/peerj.preprints.2237v5
100 downloads
962 views

We have originally shown for the first time the two different climatic patterns of seasonality of influenza and common colds have an only one common “link”. It is the effect of supersaturation and condensational growth in the upper airways which occurs under specific...

["Epidemiology","Global Health","Infectious Diseases","Public Health","Respiratory Medicine"]
doi:10.7287/peerj.preprints.2859v2
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