Preprints (not yet peer-reviewed)

26 downloads
67 views

Treatment of head louse infestation has evolved from widespread use of neurotoxic insecticides that have been extensively affected by resistance since the mid-1990s into the use of so-called physically acting treatments. It is widely believed that physically acting...

["Health Policy","Infectious Diseases","Pharmacology","Public Health","Ethical Issues"]
doi:10.7287/peerj.preprints.27412v1
189 downloads
227 views

Some marine microparasitic pathogens can survive several months outside the host in the water column to make contact with hosts or to be absorbed or filtered by hosts. Once inside, pathogens invade the host if they find suitable conditions for reproduction within...

["Ecology","Marine Biology","Mathematical Biology","Parasitology","Infectious Diseases"]
doi:10.7287/peerj.preprints.26454v3
50 downloads
85 views

Many Zika virus (ZIKV) pathogenesis-related studies have focused primarily on virus-driven pathology and neurotoxicity, instead of considering the possibility of pathogenesis as an (unintended) consequence of host innate immunity: specifically, as the side-effect...

["Bioinformatics","Neuroscience","Virology","Global Health","Infectious Diseases"]
doi:10.7287/peerj.preprints.27401v1
57 downloads
126 views

Neisseria meningitidis (Nm) and N. gonorrhoeae (Ng) are closely related pathogenic bacteria. Using those genes found across 20 Nm and 15 Ng genomes we find that Nm is 7x more diverse than Ng in their combined core genome. Both species have acquired the majority...

["Evolutionary Studies","Genetics","Genomics","Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.27382v1
32 downloads
85 views

In recent years, several computational methods have been developed to predict protein-protein interactions (PPIs) at a genome-wide level. Between them phylogenetic profiling is routinely used to infer PPIs occurring within an organism. Recent improvements of the...

["Bioinformatics","Parasitology","Infectious Diseases","Computational Science"]
doi:10.7287/peerj.preprints.27373v1
40 downloads
86 views

Tuberculosis (TB) has a long history as a major disease in humans and animals. New resistant strains are jeopardizing the advances in the battle against TB. 40% of HIV deaths occur due to concurrent TB illness. A causative agent of TB, Mycobacterium tuberculosis,...

["Biophysics","Infectious Diseases"]
doi:10.7287/peerj.preprints.27351v1
41 downloads
102 views

The field of crowdsourcing for medicine has substantially expanded. We define crowdsourcing as an organization having a large group attempt to solve community problem, then share the solution with the broader public. Large groups of individuals can participate...

["Global Health","Health Policy","Infectious Diseases","Internal Medicine","Human-Computer Interaction"]
doi:10.7287/peerj.preprints.27331v1
118 downloads
268 views

Background. Although pathogenic Gram-negative bacteria lack their own ubiquitination machinery, they have evolved or acquired virulence effectors that can manipulate the host ubiquitination process through structural and/or functional mimicry of host machinery....

["Bioinformatics","Computational Biology","Microbiology","Infectious Diseases","Data Mining and Machine Learning"]
doi:10.7287/peerj.preprints.27292v1
266 downloads
552 views

Background. Ebola Virus Disease (EVD) is a highly infectious disease that has produced over 25,000 cases in the past 50 years. While many past outbreaks resulted in relatively few cases, the 2014 outbreak in West Africa was the most deadly occurrence of EVD to...

["Epidemiology","Infectious Diseases","Statistics"]
doi:10.7287/peerj.preprints.3021v2
324 downloads
553 views

Bacteria and other microbes play a crucial role in human health and disease. Medicine and clinical microbiology have traditionally attempted to identify the etiological agents that causes disease, and how to eliminate them. Yet this traditional paradigm is becoming...

["Ecology","Evolutionary Studies","Genomics","Infectious Diseases","Translational Medicine"]
doi:10.7287/peerj.preprints.26969v2
532 downloads
1,335 views

Low-cost Illumina sequencing of clinically-important bacterial pathogens has generated thousands of publicly available genomic datasets. Analyzing these genomes and extracting relevant information for each pathogen and the associated clinical phenotypes requires...

["Bioinformatics","Genomics","Infectious Diseases","Public Health"]
doi:10.7287/peerj.preprints.26890v2
444 downloads
749 views

Klebsiella pneumoniae is an opportunistic bacterial pathogen known for its high frequency and diversity of antimicrobial resistance (AMR) genes. In addition to being a significant clinical problem in its own right, K. pneumoniae is the species within which several...

["Ecology","Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.26852v1
133 downloads
327 views

Two recent researches described the spread of East/Central/South African (ECSA) lineage of chikungunya virus (CHIKV) in the Northeastern and Southeastern Brazil (Charlys da Costa et al. 2017, Cunha et al. 2017) . Initial studies in Northern Brazil, as observed...

["Virology","Epidemiology","Infectious Diseases","Public Health","Translational Medicine"]
doi:10.7287/peerj.preprints.26707v1
114 downloads
196 views

Several studies that analyzed the burden of influenza during the 2009 pandemic found that excess mortality tended to wane or even disappear in equatorial regions, adding to evidence that suggests that seasonal influenza may have a lower impact in tropical settings....

["Epidemiology","Global Health","Infectious Diseases","Public Health","Translational Medicine"]
doi:10.7287/peerj.preprints.26705v1
117 downloads
141 views

Background. The pathogenic role of S. aureus as causative agent of serious infections and food poisoning is on the increase. However, there are few reports on comprehensive analyses of toxins and staphylococcal enterotoxin (SE) genes in S. aureus in Africa. This...

["Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.26535v1
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