Preprints (not yet peer-reviewed)

ABSTRACT Although the activation of pathogen phagocytosis via complement system has been studied, erythrocyte-phagocyte interactions in pigs are not clearly understood. Therefore, we sought to investigate the ability of porcine erythrocytes to clear immune complexes...

["Immunology"]
doi:10.7287/peerj.preprints.26881v1
66 downloads
181 views

Single-cell RNA-seq is revolutionizing our understanding of cell type heterogeneity in many fields of biology, ranging from neuroscience to cancer to immunology. In Immunology, one of the main promises of this approach is the ability to define cell types as clusters...

["Bioinformatics","Computational Biology","Evolutionary Studies","Immunology"]
doi:10.7287/peerj.preprints.26858v1
50 downloads
92 views

Serpins are a broadly distributed superfamily of protease inhibitors that are present in all kingdoms of life. The acronym, serpin, is derived from their function as potent ser ine p roteases in hibitors. Early studies of serpins focused on their functions in haemostasis...

["Biochemistry","Microbiology","Parasitology","Immunology"]
doi:10.7287/peerj.preprints.26645v1
50 downloads
139 views

Calcium signaling and body temperature are two important factors governing activation of immune cells. However, molecular identities of major players involved in such critical regulations are still unknown, especially in avian systems. In this work we explored...

["Cell Biology","Immunology","Histology"]
doi:10.7287/peerj.preprints.26614v1
25 downloads
91 views

Background. Porcine erythrocytes express complement receptor 1-like (CR1-like), which is involved in immune adherence. Methods. In this study, porcine erythrocyte samples were collected from fifty-five individual Landrace swine to characterize differences in porcine...

["Agricultural Science","Immunology"]
doi:10.7287/peerj.preprints.26596v1
75 downloads
167 views

Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that has caused tremendous economic losses worldwide. In this study, we designed a chimeric nanoparticles vaccine with the predominant epitope of FMDV (VP1 131–160) displayed on...

["Bioengineering","Biotechnology","Immunology"]
doi:10.7287/peerj.preprints.26448v1
70 downloads
176 views

The 'Hygiene hypothesis', a cornerstone model to account for the role of exogenous pathogens and later of endogenous microbiota in immune disorders, is currently presumed to operate at the innate immunity and metabolite levels to properly 'educate' the immune system....

["Immunology"]
doi:10.7287/peerj.preprints.3237v1
94 downloads
293 views

Prevailing immunological dogma dictates self-nonself discrimination, meaning to respond or not, and effector class regulation, meaning choosing the most effective response, are two separate decisions the immune system makes when faced with a new antigen. Representing...

["Immunology"]
doi:10.7287/peerj.preprints.3081v1
40 downloads
189 views

Chlamydia trachomatis is usally isolated only from humans and is often infected together with other sexually transmitted diseases(STD). C. trachomatis is a serious disease which infects 500 million people per year globally and causes blindness in 7 to 9 million...

["Biochemistry","Microbiology","Molecular Biology","Immunology","Infectious Diseases"]
doi:10.7287/peerj.preprints.3056v1
43 downloads
438 views

BACKGROUND: 2’-4’ Dinitrofluorobenzene (DNFB) induced contact hypersensitivity is an established model of contact sensitivity and leukocyte migration. Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) deficient mice were used to examine the role of PECAM-1...

["Cell Biology","Dermatology","Immunology"]
doi:10.7287/peerj.preprints.2947v2
85 downloads
269 views

Cytokines are fundamental for a functioning immune system, and thus, potentially serve as important indicators of animal health. Quantitation of mRNA using quantitative reverse transcription polymerase chain reaction (qRT-PCR) is an established immunological technique....

["Marine Biology","Molecular Biology","Veterinary Medicine","Immunology"]
doi:10.7287/peerj.preprints.2735v1
566 downloads
915 views

“Omics” studies generate long lists of genes, proteins, metabolites or other features which can be difficult to decipher. Feature set enrichment analysis utilizing annotated groups/classes of features (such as pathways, gene ontology terms or gene/metabolic modules)...

["Bioinformatics","Immunology","Statistics","Metabolic Sciences","Computational Science"]
doi:10.7287/peerj.preprints.2420v1
243 downloads
597 views

In aggressive solid tumors like melanoma, a strategy for therapy personalization can be achieved by combining high-throughput data on the patient’s specific tumor mutation and expression profiles. A remarkable case is dendritic cell-based immunotherapy, where tumor...

["Bioinformatics","Dermatology","Immunology"]
doi:10.7287/peerj.preprints.2385v1
80 downloads
229 views

Snakebite envenomings represent a neglected public health issue in many parts of the rural tropical world. Animal-derived antivenoms have existed for more than a hundred years and are effective in neutralizing snake venom toxins when timely administered. However,...

["Bioinformatics","Biotechnology","Toxicology","Immunology","Synthetic Biology"]
doi:10.7287/peerj.preprints.2364v1
421 downloads
339 views

Different types of stem cells are targeted by a number of cytokines that alter proliferation, differentiation, or other properties of stem cells. Stem cells are known to express various cytokine genes. As IL-12, IL-14, G-CSF, and GM-CSF expression is lost after...

["Allergy and Clinical Immunology","Immunology"]
doi:10.7287/peerj.preprints.2347v1
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