Preprints (not yet peer-reviewed)

132 downloads
207 views

Objectives: Dose-response meta-analysis (DRMA) is widely employed to establishing the potential dose-response relationship between continuous exposures and disease outcomes. However, no method is readily available for exploring the relation between a discrete exposure...

["Epidemiology","Evidence Based Medicine","Internal Medicine","Public Health","Statistics"]
doi:10.7287/peerj.preprints.27277v1
73 downloads
132 views

The modern day medical professional needs to be able to work successfully in a team to ensure that the provision of a full range of care is provided to meet the wide needs of patients. However, traditional team skill training, that is much beloved of many Business...

["Evidence Based Medicine","Health Policy","Science and Medical Education"]
doi:10.7287/peerj.preprints.27188v1
164 downloads
231 views

Background Guidelines are systematically developed recommendations to assist practitioner and patient decisions about treatments for clinical conditions. Researchers, healthcare professionals and policy makers need to be able to retrieve clinical practice guidelines...

["Epidemiology","Evidence Based Medicine","Health Policy","Science and Medical Education","Statistics"]
doi:10.7287/peerj.preprints.27149v1
96 downloads
272 views

GDF11, a member of TGF-β superfamily, has recently received widespread attention as a novel anti-ageing/rejuvenation factor to reverse age-related dysfunctions in heart and skeletal muscle, and to induce angiogenesis and neurogenesis. However, these positive effects...

["Biochemistry","Bioinformatics","Cell Biology","Neuroscience","Evidence Based Medicine"]
doi:10.7287/peerj.preprints.27003v1
590 downloads
770 views

“Open access” has become a central theme of journal reform in academic publishing. In this article, I examine the relationship between open access publishing and an important infrastructural element of a modern research enterprise, scientific literature text mining,...

["Bioinformatics","Evidence Based Medicine","Health Policy","Translational Medicine","Science Policy"]
doi:10.7287/peerj.preprints.2566v2
185 downloads
490 views

The “reproducibility crisis” has been a highly visible source of scientific controversy and dispute. Here, I propose and review several avenues for identifying and prioritizing research studies for the purpose of targeted validation. Of the various proposals discussed,...

["Bioinformatics","Evidence Based Medicine","Health Policy","Translational Medicine","Science Policy"]
doi:10.7287/peerj.preprints.2830v2
1,085 downloads
601 views

Primary care services in England may be reaching saturation point. Demands to see a GP or practice nurse have increased substantially. Clinical complexity has also increased; patients are living longer, but with more multimorbidity.(1) These demands are mirrored...

["Emergency and Critical Care","Evidence Based Medicine","Science Policy"]
doi:10.7287/peerj.preprints.15934v1
148 downloads
513 views

Statistical significance provides evidence for or against an explanation of a population of interest, not a description of data sampled from the population. This simple distinction gets ignored in hundreds of thousands of research publications yearly, which confuse...

["Ecology","Evidence Based Medicine","Oncology","Statistics","Environmental Impacts"]
doi:10.7287/peerj.preprints.3394v1
208 downloads
550 views

Abstract Ginsenoside Rk1 (G-Rk1) is one of the unique components created by processing ginseng at high temperature, in particular of Sun Ginseng (SG). The aim of our study was to systematically review the pharmacological effects of G-Rk1.we conducted our search...

["Plant Science","Evidence Based Medicine","Pharmacology"]
doi:10.7287/peerj.preprints.3013v1
32,137 downloads
1,296 views

Meta analysis refers to a process of integration of the results of many studies to arrive at evidence syn- thesis. Meta analysis is similar to systematic review; however, in addition to narrative summary that is conducted in systematic review, in meta analysis,...

["Epidemiology","Evidence Based Medicine","Health Policy","Public Health","Statistics"]
doi:10.7287/peerj.preprints.2978v1
6,014 downloads
13,270 views

Background: Paediatric SLT roles often involve planning individualised intervention for specific children (provided directly by SLTs or indirectly through non-SLTs), working collaboratively with families and education staff and providing advice and training. A...

["Cognitive Disorders","Evidence Based Medicine","Pediatrics","Psychiatry and Psychology","Public Health"]
doi:10.7287/peerj.preprints.2951v1
187 downloads
376 views

Objective: The purpose of this study was to demonstrate the effects of the achievement motive on important variables such as the purpose in life and social participation with objective physical functions in predicting within-person fluctuations and between-person...

["Evidence Based Medicine","Geriatrics","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.2801v1
100 downloads
584 views

BACKGROUND: The use of public engagement and self-management in online clinical trials is growing with benefits, boundaries and minimal methodological guidance. This analysis explores whether running self-recruited online trials can provide trustworthy and useful...

["Clinical Trials","Evidence Based Medicine","Global Health","Public Health","Science and Medical Education"]
doi:10.7287/peerj.preprints.2671v1
250 downloads
340 views

Developing new endpoints for mobility is an important strategic aim for many groups both in industry and academia and the focus of a growing field. Bringing those novel endpoints to health authority acceptance for clinical decision making will require a concerted...

["Clinical Trials","Evidence Based Medicine","Translational Medicine","Computational Science"]
doi:10.7287/peerj.preprints.2546v1
817 downloads
334 views

This is a tutorial on how to use the GRADEPro GDT guidelines development tool for appraisal of articles. The tutorial assumes that the student has little experience of working with Gradepro and walks through in several steps how to use this tool. Grading of evidence...

["Evidence Based Medicine","Science and Medical Education"]
doi:10.7287/peerj.preprints.2520v1
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