Preprints (not yet peer-reviewed)

27 downloads
77 views

Explaining the variability in drug sensitivity across a panel of cell lines using genomic information is a key aspect of cancer drug discovery. The results of such analyses may ultimately determine which patients are likely to benefit from a new treatment. There...

["Bioinformatics","Computational Biology","Genomics","Drugs and Devices","Oncology"]
doi:10.7287/peerj.preprints.27345v1
102 downloads
207 views

Background. Mesenchymal stem/stromal cells (MSCs) are a promising tool for cell-based therapies in the treatment of tissue injury. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis plays a significant role in directing MSC homing to...

["Cell Biology","Mathematical Biology","Drugs and Devices"]
doi:10.7287/peerj.preprints.27144v1
516 downloads
846 views

The classical way of defining enzyme inhibition has obscured the distinction between inhibitory effect and the inhibitor binding constant. This article examines the relationship between the simple binding curve used to define biomolecular interactions and the standard...

["Biochemistry","Computational Biology","Mathematical Biology","Drugs and Devices","Pharmacology"]
doi:10.7287/peerj.preprints.3094v2
123 downloads
295 views

In recent years, the pharmaceutical industry has been confronted with rising R&D costs paired with decreasing productivity. Attrition rates for new molecules are tremendous, with a substantial number of molecules failing in an advanced stage of development. Repositioning...

["Bioinformatics","Drugs and Devices","Computational Science","Data Mining and Machine Learning","Data Science"]
doi:10.7287/peerj.preprints.27002v1
1,741 downloads
2,616 views

Horseshoe crabs have been integral to the safe production of vaccines and injectable medications for the past forty years. The bleeding of live horseshoe crabs, a process that leaves thousands dead annually, is an ecologically unsustainable practice for all four...

["Conservation Biology","Drugs and Devices","Pharmacology","Synthetic Biology","Environmental Impacts"]
doi:10.7287/peerj.preprints.26922v1
482 downloads
315 views

Background. Beyond its traditional uses in the Balkan area, Sideritis scardica (known as Greek mountain tea, Lamiaceae) is currently extensively investigated for its pharmacological activity in the central nervous system. Antidepressant, psychostimulating, cognition-enhancing...

["Cognitive Disorders","Drugs and Devices","Pharmacology"]
doi:10.7287/peerj.preprints.3483v1
3,493 downloads
793 views

Underpowered experiments have three problems: the probability of a false positive result is higher, true effects are harder to detect, and the true effects that are detected tend to have inflated effect sizes. Many biology experiments are underpowered and recent...

["Animal Behavior","Neuroscience","Drugs and Devices","Ethical Issues","Statistics"]
doi:10.7287/peerj.preprints.3363v1
66 downloads
193 views

Background. Microdialysis is a valued method to study the pharmacokinetics of drug distribution from an injection site or to a tumor site. The objective of this study was to assess the feasibility of prolonged use of subcutaneously implanted microdialysis catheters...

["Drugs and Devices","Oncology","Pharmacology"]
doi:10.7287/peerj.preprints.3324v1
135 downloads
398 views

1,4-dihydropyridines (1,4-DHP) possess important biochemical and pharmacological properties, including antioxidant and antimutagenic activities. Interaction of some 1,4-DHP with DNA was recently reported. AV-153-Na, an antimutagenic and DNA-repair-enhancing compound...

["Biophysics","Drugs and Devices"]
doi:10.7287/peerj.preprints.3317v1
111 downloads
458 views

Purpose: To compare the intraoperative angle stability and the postoperative outflow of two ab interno trabeculectomy devices that excise the trabecular meshwork. The newer device has an active aspiration and irrigation port while the older requires viscoelastic...

["Drugs and Devices","Ophthalmology","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.2762v2
96 downloads
243 views

Natural product libraries are important tools for drug discovery. However, until now, there has not been a system to allow projections of the potential number of hits from creating these libraries. The objective of this study was to develop a stochastic model system...

["Biodiversity","Biotechnology","Microbiology","Drugs and Devices","Computational Science"]
doi:10.7287/peerj.preprints.2734v1
198 downloads
401 views

Drug discovery is a step-by-step process very important in biopharmaceutical field. We are interested in identifying new investigational drug-likes as potential inhibitors of determinate biological-therapeutic targets, trying to decrease the side effects and to...

["Bioinformatics","Computational Biology","Drugs and Devices"]
doi:10.7287/peerj.preprints.2639v1
153 downloads
384 views

Motivation. The human chymase (EC 3.4.21.39) is a hydrolase abundant in secretory granules of mast cells, responsible for the synthesis of angiotensin II from its precursor. Moreover, it is also responsible for the conversion of transforming growth factor-β (TGF-β)...

["Biochemistry","Bioinformatics","Computational Biology","Drugs and Devices"]
doi:10.7287/peerj.preprints.2185v1
65 downloads
201 views

It is well known that the biological properties of compounds are directly related to the configuration of their stereogenic centers. Therefore, the determination of the compound spatial structure, including its configuration, is crucial for better understanding...

["Biophysics","Drugs and Devices","Science and Medical Education"]
doi:10.7287/peerj.preprints.1935v1
344 downloads
486 views

Background: Arterial thrombosis causes heart attacks and strokes and constitutes one of the leading causes of morbidity and mortality in the world and few therapies are available for its treatment. Thus, new therapeutic approaches in the prevention and treatment...

["Biochemistry","Bioinformatics","Cardiology","Drugs and Devices"]
doi:10.7287/peerj.preprints.1919v1
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