Preprints (not yet peer-reviewed)

34 downloads
99 views

Neurological diseases (NDs) are progressive disorder often advances with age and comorbidities of Type 2 diabetes (T2D). Epidemiological, clinical and neuropathological evidence advocate that patients with T2D are at an increased risk of getting NDs. However, it...

["Bioinformatics","Computational Biology","Genetics","Genomics","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.27323v1
55 downloads
129 views

Tropomodulins (Tmods) are proteins that cap the slow growing (pointed) ends of actin filaments (F-actin). The basis for our current understanding of Tmod function comes from studies in cells with relatively stable and highly organized F-actin networks, leading...

["Biochemistry","Cell Biology","Molecular Biology","Anatomy and Physiology","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.27172v1
51 downloads
160 views

Characterized by high blood glucose concentration, resistance of cells to glucose uptake and reduced insulin sensitivity, Type II diabetes is a major health problem afflicting both developing and developed countries in increasing extent as populations around the...

["Biochemistry","Cell Biology","Diabetes and Endocrinology","Internal Medicine","Metabolic Sciences"]
doi:10.7287/peerj.preprints.27024v1
99 downloads
421 views

Background. Type 2 diabetes, a chronic disease to which susceptibility is hereditary, is characterized by insulin resistance accompanied by defective insulin secretion. Mouse models, especially transgenic mice, play an important role in medical research. However,...

["Agricultural Science","Biotechnology","Diabetes and Endocrinology","Histology","Medical Genetics"]
doi:10.7287/peerj.preprints.3437v1
221 downloads
196 views

Objective: In China, the obesity epidemic is truly national and childhood obesity prevalence has rapidly increased and is close to the developed countries. This study aimed to estimate the prevalence and temporal trends of overweight and obesity among children...

["Diabetes and Endocrinology","Epidemiology"]
doi:10.7287/peerj.preprints.3207v1
360 downloads
760 views

Background: Salvia officinalis (sage) is a native plant to the Mediterranean region and has been used for a long time in traditional medicine for various diseases. We investigated possible anti-diabetic, anti-inflammatory and anti-obesity effects of sage methanol...

["Diabetes and Endocrinology","Nutrition","Translational Medicine"]
doi:10.7287/peerj.preprints.3086v1
56 downloads
213 views

Objective: This study aims to compare the sensitivity of dual phase (non-contrast and arterial) versus single phase (arterial) CT for detection of hyper-functioning parathyroid glands in patients with primary hyperparathyroidism. Methods: The CT scans of thirty-two...

["Diabetes and Endocrinology","Radiology and Medical Imaging"]
doi:10.7287/peerj.preprints.3058v1
146 downloads
379 views

Background. The current study aims to explore the effects of advanced glycation end products (AGEs) on the microRNA (miRNA) expression profile in kidney tissues in a murine diabetic nephropathy (DN) model, and to investigate the possible underlying mechanisms....

["Genomics","Molecular Biology","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.3026v1
144 downloads
659 views

Trichoplax adhaerens, the only known species of Placozoa is likely to be closely related to an early metazoan that preceded branching of Cnidaria and Bilateria. This animal species is surprisingly well adapted to free life in the World Ocean inhabiting tidal costal...

["Evolutionary Studies","Genomics","Molecular Biology","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.2945v1
131 downloads
323 views

Background. Currently, the number of obese people in the world has reached alarming proportions. During the expansion of adipose tissue, a number of functions such as activation and release of cytokines and hormones may be affected. This causes the body to take...

["Diabetes and Endocrinology","Nutrition"]
doi:10.7287/peerj.preprints.2535v1
344 downloads
440 views

Steroids play multiple roles in the regulation of development, physiology, reproduction, and behavior. Measuring circulating steroids is especially challenging since concentrations are extremely labile, responding to stressors within minutes. Matrices that integrate...

["Andrology","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.2069v2
167 downloads
741 views

Aim/hypothesis The aim of our study was to characterize the human salivary proteome and determine the changes in protein expression in 2 different stages of diabetic retinopathy with type-2 diabetes mellitus: (1) with non-proliferative diabetic retinopathy (NPDR)...

["Biochemistry","Diabetes and Endocrinology","Ophthalmology"]
doi:10.7287/peerj.preprints.1973v1
392 downloads
727 views

Purpose. Type 2 diabetes is the leading cause of end stage renal disease in the United States. Atherosclerotic renal artery stenosis is commonly observed in diabetic patients and impacts the rate of renal and cardiovascular disease progression. We hypothesized...

["Cardiology","Diabetes and Endocrinology","Nephrology","Pathology","Translational Medicine"]
doi:10.7287/peerj.preprints.1323v2
281 downloads
449 views

The growing number of wildlife endocrinology studies have greatly enhanced our understanding of comparative endocrinology, and have also generated extensive longitudinal data for a vast number of species. However, the extensive graphical analysis required for these...

["Biodiversity","Computational Biology","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.1546v1
216 downloads
317 views

Type 2 diabetes mellitus (T2DM) is a chronic and progressive disease that is strongly associated with the all-cause and cardiovascular mortality. The present study aimed to analyze the abundance and functionality of intrinsically disordered regions in several biomarkers...

["Biochemistry","Bioinformatics","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.1395v1
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