Preprints (not yet peer-reviewed)

26 downloads
51 views

Clinical studies/trials are experiments or observations on human subjects considered by the scientific community the most appropriate instrument to answer specific research questions on interventions on health outcomes. The time-line of the observations might be...

["Bioinformatics","Clinical Trials","Epidemiology","Statistics","Data Mining and Machine Learning"]
doi:10.7287/peerj.preprints.27385v1
55 downloads
135 views

Background. The attribution of non-ClinicalTrials.gov registries among registered trials of the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) had increased until 2013. However, the attribution after 2013 is unknown. Moreover,...

["Clinical Trials","Epidemiology"]
doi:10.7287/peerj.preprints.27298v1
546 downloads
1,188 views

Background: Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulatory technique that has shown encouraging results regarding performance improvement of normal subjects in tests of executive functions. Moreover, when applied repeatedly in...

["Clinical Trials","Neurology","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.1610v2
58 downloads
131 views

Background: Medical decision-making is difficult when information is limited due to rareness. For example, there are two treatment options for patients affected by a rare disease with high lethality. The information about both treatment effects is unavailable or...

["Bioinformatics","Clinical Trials","Public Health","Ethical Issues","Statistics"]
doi:10.7287/peerj.preprints.27170v1
90 downloads
211 views

Background. Studies with positive findings are more likely to be published compared to those with negative findings. Therefore the latter studies are often disregarded in systematic reviews. This causes an overestimation of a treatment effect size which leads to...

["Clinical Trials"]
doi:10.7287/peerj.preprints.26981v1
411 downloads
385 views

Many difficulties are encountered by people with disabilities, especially when a diagnosis is made up of more than one dysfunction, as is the case of visually impaired wheelchair users. In fact, this scenario generates a degree of incapacity in terms of the performing...

["Bioengineering","Bioinformatics","Neuroscience","Clinical Trials","Human-Computer Interaction"]
doi:10.7287/peerj.preprints.3036v1
100 downloads
584 views

BACKGROUND: The use of public engagement and self-management in online clinical trials is growing with benefits, boundaries and minimal methodological guidance. This analysis explores whether running self-recruited online trials can provide trustworthy and useful...

["Clinical Trials","Evidence Based Medicine","Global Health","Public Health","Science and Medical Education"]
doi:10.7287/peerj.preprints.2671v1
79 downloads
314 views

We comment on the recent developments and problems of three-dimensional printing in cardiology. Since there are currently no standards or consensuses for 3D printing in clinical medicine and the technology is at its infancy in cardiology, it’s very important to...

["Anatomy and Physiology","Cardiology","Clinical Trials","Radiology and Medical Imaging"]
doi:10.7287/peerj.preprints.2597v1
250 downloads
340 views

Developing new endpoints for mobility is an important strategic aim for many groups both in industry and academia and the focus of a growing field. Bringing those novel endpoints to health authority acceptance for clinical decision making will require a concerted...

["Clinical Trials","Evidence Based Medicine","Translational Medicine","Computational Science"]
doi:10.7287/peerj.preprints.2546v1
127 downloads
247 views

Wearable physiological sensors have the projected capability to detect unknown and unreported health conditions. Development requires rounds of discovery-oriented human subject research and confirmatory clinical trials. However, each study is a significant investment...

["Clinical Trials","Epidemiology","Infectious Diseases","Public Health","Ethical Issues"]
doi:10.7287/peerj.preprints.2079v1
108 downloads
355 views

Background. Interventions and services for people with mental health problems can have broad remits: they are often designed to treat people with a variety of diagnoses. Furthermore, addressing mental health problems can have long term implications for economic,...

["Clinical Trials","Evidence Based Medicine","Psychiatry and Psychology"]
doi:10.7287/peerj.preprints.1988v1
179 downloads
400 views

In publication of a controlled trial article from health science research, the abstract is an important part that readers usually read first and then decide whether to read the whole article; therefore, information provided in the abstract should be adequate. The...

["Agricultural Science","Veterinary Medicine","Clinical Trials","Evidence Based Medicine"]
doi:10.7287/peerj.preprints.1945v1
62 downloads
324 views

Conventional methods in this field include identifying and screening compounds in a laboratory setting with cells and animals, and then moving on to clinical trials with promising compounds. To complicate the issue with these methods, effective compounds might...

["Clinical Trials","Drugs and Devices"]
doi:10.7287/peerj.preprints.1902v1
82 downloads
178 views

Background: Simtics Integrated Cognitive Simulator (ICS) is a software learning environment, previously demonstrated to be of use to surgical trainees in learning the cognitive aspects of procedural skills. It also includes a Test-Mode, which has not previously...

["Clinical Trials","Surgery and Surgical Specialties","Human-Computer Interaction","Computational Science"]
doi:10.7287/peerj.preprints.1893v1
3,731 downloads
605 views

The FDA adaptive trial design guidance (1) is a thoughtful but lengthy document that explains on 50 pages wide-ranging and important topics “such as ... what aspects of adaptive design trials (i.e., clinical, statistical, regulatory) call for special consideration,...

["Clinical Trials","Drugs and Devices","Statistics"]
doi:10.7287/peerj.preprints.1825v1
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