Preprints (not yet peer-reviewed)

26 downloads
122 views

Rodent grimace scales facilitate assessment of spontaneous pain and can identify a range of acute pain levels. Reported rater training in using these scales varies considerably and may contribute to observed variability in inter-rater reliability. This study evaluated...

["Animal Behavior","Veterinary Medicine","Anesthesiology and Pain Management"]
doi:10.7287/peerj.preprints.26721v2
101 downloads
209 views

Role of glial cells in pain modulation has recently gathered attention. The objective of this study was to determine healthy spinal microglia and astrocyte morphology and disposition in equine spinal cord dorsal horns using Iba-1 and GFAP/Cx-43 immunofluorescence...

["Anesthesiology and Pain Management","Molecular Biology","Neuroscience","Veterinary Medicine"]
doi:10.7287/peerj.preprints.3066v1
41 downloads
257 views

Background: Chronic diseases have become a global public health issue, and mass media campaigns are often used to encourage and sustain positive behavior change. Our aim was to evaluate the effect of public service advertising on the awareness of Chongqing citizens....

["Anesthesiology and Pain Management"]
doi:10.7287/peerj.preprints.2985v1
40 downloads
318 views

Background: Respondent fatigue, also known as survey fatigue, is a common problem in the collection of survey data. Factors that are known to influence respondent fatigue include survey length, survey topic, question complexity, and open-ended question type. There...

["Anesthesiology and Pain Management","Global Health","Human-Computer Interaction","Statistics"]
doi:10.7287/peerj.preprints.2939v1
155 downloads
407 views

Historically, handling insects has usually involved their being killed, but non-lethal approaches are necessary when evaluating the biology of such organisms. Anesthesia has been used as one of these non-lethal approaches. Two common anesthetics used in this way...

["Anesthesiology and Pain Management","Entomology","Toxicology"]
doi:10.7287/peerj.preprints.2874v1
64 downloads
346 views

Background. Osteoarthritis is the leading cause of chronic joint pain, causing important productivity and economic losses. It is believed that peripheral and centralized sensitization play a role in the creation and maintenance of a chronic painful state. Different...

["Anesthesiology and Pain Management","Pharmacology","Rheumatology","Translational Medicine"]
doi:10.7287/peerj.preprints.2704v1
631 downloads
197 views

Historically, handling insects usually involved their being killed as early studies used these organisms for work on genetics, physiology and/or pesticide bioassays. With the advancement of these research topics, the development of behavioral studies and the sensitivity...

["Agricultural Science","Anesthesiology and Pain Management","Animal Behavior","Entomology"]
doi:10.7287/peerj.preprints.2571v1
117 downloads
242 views

Objectives: Use of clinical audits to assess and improve perioperative hypothermia management in client-owned dogs. Methods: Two clinical audits were performed. Audit 1: data were collected to determine the incidence and duration of perioperative hypothermia (defined...

["Anesthesiology and Pain Management","Veterinary Medicine"]
doi:10.7287/peerj.preprints.2350v1
392 downloads
363 views

A 6-year-old female Shetland Sheepdog with a history of cardiorespiratory compromise during general anaesthesia was referred for ovariohysterectomy surgery. Clinical examination was unremarkable at presentation and physiologic parameters under general anaesthesia...

["Allergy and Clinical Immunology","Anesthesiology and Pain Management","Emergency and Critical Care","Pharmacology","Veterinary Medicine"]
doi:10.7287/peerj.preprints.2275v1
104 downloads
320 views

Paclitaxel, a chemotherapeutic agent, causes neuropathic pain whose supraspinal pathophysiology is not fully understood. Dysregulation of sodium channel expression, studied mainly in the periphery and spinal cord level, contributes to the pathogenesis of neuropathic...

["Anesthesiology and Pain Management","Molecular Biology","Neuroscience","Pharmacology"]
doi:10.7287/peerj.preprints.1936v1
99 downloads
297 views

Background. Medications are not exempt from adverse drug reactions (ADR) and how the physician perceives the risk of prescription drugs could influence their availability to report ADR and their prescription behavior. Methods. We assess the perception of risk and...

["Anesthesiology and Pain Management","Pharmacology","Public Health","Science and Medical Education"]
doi:10.7287/peerj.preprints.1890v1
176 downloads
553 views

Valproate, an indirect γ-aminobutiric acid agonist has been successfully used in various painful conditions. Despite its frequent use, limited pre-clinical and clinical data exist about its analgesic effect. We tested valproate p.o. in increasing doses (10, 25,...

["Anesthesiology and Pain Management","Neuroscience","Pharmacology"]
doi:10.7287/peerj.preprints.1613v1
594 downloads
569 views

Tramadol is used in both human and veterinary medicine to treat postoperative pain. The purpose of this study was to evaluate tramadol as a sole postoperative analgesic and to compare drug plasma concentration to clinical pain score. A high or low dose of tramadol...

["Anesthesiology and Pain Management","Evidence Based Medicine","Pharmacology","Surgery and Surgical Specialties"]
doi:10.7287/peerj.preprints.1510v1
136 downloads
599 views

Spinal astrocyte activation contributes to the pathogenesis of paclitaxel-induced neuropathic pain (PINP) in animal models. We examined glial fibrillary acidic protein (GFAP; an astrocyte marker) immunoreactivity and gene expression of GFAP, glutamate transporters...

["Anesthesiology and Pain Management","Molecular Biology","Neuroscience","Pharmacology"]
doi:10.7287/peerj.preprints.1246v2
2,916 downloads
934 views

Manual therapy has long been a component of physical rehabilitation programs, especially to treat those in pain. The mechanisms of manual therapy, however, are not fully understood, and it has been suggested that its pain modulatory effects are of neurophysiological...

["Anatomy and Physiology","Anesthesiology and Pain Management","Neuroscience"]
doi:10.7287/peerj.preprints.996v2
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