Preprints (not yet peer-reviewed)

17 downloads
67 views

Clinical bioinformatics, translational bioinformatics and personalised medicine are connected by the common task of analysing and integrating clinical data and results, in order to find important biomarkers related to pathologies and facilitate their prediction,...

["Bioinformatics","Computational Biology","Pathology","Statistics","Data Science"]
doi:10.7287/peerj.preprints.27398v1
293 downloads
435 views

We obviously do not encourage scientific fraud nor misconduct. The goal of this article is to alert the reader to problems that have arisen in part due to the Publish or Perish imperative, which has driven a number of researchers to cross the Rubicon without the...

["Legal Issues","Science and Medical Education","Science Policy","Statistics"]
doi:10.7287/peerj.preprints.27395v1
25 downloads
50 views

Clinical studies/trials are experiments or observations on human subjects considered by the scientific community the most appropriate instrument to answer specific research questions on interventions on health outcomes. The time-line of the observations might be...

["Bioinformatics","Clinical Trials","Epidemiology","Statistics","Data Mining and Machine Learning"]
doi:10.7287/peerj.preprints.27385v1
1,489 downloads
3,482 views

This article proposes quantitative answers to meta-scientific questions including "how much knowledge is attained by a research field?","how rapidly is a field making progress?", "what is the expected reproducibility of a result?", "how much knowledge is lost from...

["Computational Biology","Ethical Issues","Science Policy","Statistics","Computational Science"]
doi:10.7287/peerj.preprints.1968v5
1,013 downloads
1,367 views

In this paper, we discuss an extension to two popular approaches to modelling complex structures in ecological data: the generalized additive model (GAM) and the hierarchical model (HGLM). The hierarchical GAM (HGAM), allows modelling of nonlinear functional relationships...

["Ecology","Statistics","Data Science"]
doi:10.7287/peerj.preprints.27320v1
3,347 downloads
7,861 views

Statistical inference often fails to replicate. One reason is that many results may be selected for drawing inference because some threshold of a statistic like the P-value was crossed, leading to biased reported effect sizes. Nonetheless, considerable non-replication...

["Science and Medical Education","Science Policy","Statistics","Data Science"]
doi:10.7287/peerj.preprints.26857v4
132 downloads
207 views

Objectives: Dose-response meta-analysis (DRMA) is widely employed to establishing the potential dose-response relationship between continuous exposures and disease outcomes. However, no method is readily available for exploring the relation between a discrete exposure...

["Epidemiology","Evidence Based Medicine","Internal Medicine","Public Health","Statistics"]
doi:10.7287/peerj.preprints.27277v1
53 downloads
125 views

Background: Fecal microbiota transplantation (FMT) is an emerging therapy against Clostridium difficile infection (CDI) and inflammatory bowel disease (IBD). Although the therapy has gained prominence, there has been no bibliometric analysis of FMT. Methods: Studies...

["Gastroenterology and Hepatology","Global Health","Statistics"]
doi:10.7287/peerj.preprints.27259v1
104 downloads
336 views

Translational models that utilize omics data generated in in vitro studies to predict the drug efficacy of anti-cancer compounds in patients are highly distinct, which complicates the benchmarking process for new computational approaches. In reaction to this, we...

["Computational Biology","Genomics","Statistics","Data Mining and Machine Learning"]
doi:10.7287/peerj.preprints.27256v1
189 downloads
219 views

The number of bioinformatics resources, such as tools/scripts and databases are growing exponentially. This poses a great challenge for users to access, manage, and integrate the corresponding bioinformatics resources. To facilitate the request, we proposed a comprehensive...

["Bioinformatics","Statistics"]
doi:10.7287/peerj.preprints.27221v1
9,050 downloads
13,806 views

Spreadsheets are widely used software tools for data entry, storage, analysis, and visualization. Focusing on the data entry and storage aspects, this paper offers practical recommendations for organizing spreadsheet data to reduce errors and ease later analyses....

["Computational Biology","Science and Medical Education","Statistics","Computational Science","Data Science"]
doi:10.7287/peerj.preprints.3183v2
356 downloads
503 views

The sixth mass extinction poses an unparalleled quantitative challenge to conservation biologists. Mathematicians and ecologists alike face the problem of developing models that can scale predictions of extinction rates from populations to the level of a species,...

["Conservation Biology","Ecology","Mathematical Biology","Statistics","Climate Change Biology"]
doi:10.7287/peerj.preprints.3367v2
58 downloads
131 views

Background: Medical decision-making is difficult when information is limited due to rareness. For example, there are two treatment options for patients affected by a rare disease with high lethality. The information about both treatment effects is unavailable or...

["Bioinformatics","Clinical Trials","Public Health","Ethical Issues","Statistics"]
doi:10.7287/peerj.preprints.27170v1
532 downloads
640 views

Biological color may be adaptive or incidental, seasonal or permanent, species- or population-specific, or modified for breeding, defense or camouflage. Although color is a hugely informative aspect of biology, quantitative color comparisons are notoriously difficult....

["Biodiversity","Evolutionary Studies","Statistics"]
doi:10.7287/peerj.preprints.26487v2
160 downloads
228 views

Background Guidelines are systematically developed recommendations to assist practitioner and patient decisions about treatments for clinical conditions. Researchers, healthcare professionals and policy makers need to be able to retrieve clinical practice guidelines...

["Epidemiology","Evidence Based Medicine","Health Policy","Science and Medical Education","Statistics"]
doi:10.7287/peerj.preprints.27149v1
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