Preprints (not yet peer-reviewed)

Objectives: Dose-response meta-analysis (DRMA) is widely employed to establishing the potential dose-response relationship between continuous exposures and disease outcomes. However, no method is readily available for exploring the relation between a discrete exposure...

["Epidemiology","Evidence Based Medicine","Internal Medicine","Public Health","Statistics"]
doi:10.7287/peerj.preprints.27277v1
1,661 downloads
4,646 views

Statistical inference often fails to replicate. One reason is that many results may be selected for drawing inference because some threshold of a statistic like the P-value was crossed, leading to biased effect sizes. Nonetheless, considerable non-replication is...

["Science and Medical Education","Science Policy","Statistics","Data Science"]
doi:10.7287/peerj.preprints.26857v3
28 downloads
74 views

Background: Fecal microbiota transplantation (FMT) is an emerging therapy against Clostridium difficile infection (CDI) and inflammatory bowel disease (IBD). Although the therapy has gained prominence, there has been no bibliometric analysis of FMT. Methods: Studies...

["Gastroenterology and Hepatology","Global Health","Statistics"]
doi:10.7287/peerj.preprints.27259v1
56 downloads
227 views

Translational models that utilize omics data generated in in vitro studies to predict the drug efficacy of anti-cancer compounds in patients are highly distinct, which complicates the benchmarking process for new computational approaches. In reaction to this, we...

["Computational Biology","Genomics","Statistics","Data Mining and Machine Learning"]
doi:10.7287/peerj.preprints.27256v1
86 downloads
180 views

The number of bioinformatics resources, such as tools/scripts and databases are growing exponentially. This poses a great challenge for users to access, manage, and integrate the corresponding bioinformatics resources. To facilitate the request, we proposed a comprehensive...

["Bioinformatics","Statistics"]
doi:10.7287/peerj.preprints.27221v1
8,056 downloads
12,967 views

Spreadsheets are widely used software tools for data entry, storage, analysis, and visualization. Focusing on the data entry and storage aspects, this paper offers practical recommendations for organizing spreadsheet data to reduce errors and ease later analyses....

["Computational Biology","Science and Medical Education","Statistics","Computational Science","Data Science"]
doi:10.7287/peerj.preprints.3183v2
217 downloads
460 views

The sixth mass extinction poses an unparalleled quantitative challenge to conservation biologists. Mathematicians and ecologists alike face the problem of developing models that can scale predictions of extinction rates from populations to the level of a species,...

["Conservation Biology","Ecology","Mathematical Biology","Statistics","Climate Change Biology"]
doi:10.7287/peerj.preprints.3367v2
41 downloads
108 views

Background: Medical decision-making is difficult when information is limited due to rareness. For example, there are two treatment options for patients affected by a rare disease with high lethality. The information about both treatment effects is unavailable or...

["Bioinformatics","Clinical Trials","Public Health","Ethical Issues","Statistics"]
doi:10.7287/peerj.preprints.27170v1
385 downloads
595 views

Biological color may be adaptive or incidental, seasonal or permanent, species- or population-specific, or modified for breeding, defense or camouflage. Although color is a hugely informative aspect of biology, quantitative color comparisons are notoriously difficult....

["Biodiversity","Evolutionary Studies","Statistics"]
doi:10.7287/peerj.preprints.26487v2
89 downloads
198 views

Background Guidelines are systematically developed recommendations to assist practitioner and patient decisions about treatments for clinical conditions. Researchers, healthcare professionals and policy makers need to be able to retrieve clinical practice guidelines...

["Epidemiology","Evidence Based Medicine","Health Policy","Science and Medical Education","Statistics"]
doi:10.7287/peerj.preprints.27149v1
80 downloads
135 views

Background. Functional groups serve two important functions in ecology, they allow for simplification of ecosystem models and can aid in understanding diversity. Despite their important applications, there has not been a universally accepted method of how to define...

["Ecology","Marine Biology","Statistics","Data Mining and Machine Learning","Data Science"]
doi:10.7287/peerj.preprints.27148v1
64 downloads
131 views

In genetic studies, quantitative traits are found possibly associated with genetic data. Due to advanced sequencing technology, many methods have been proposed in genome wide association study (GWAS) to search the single nucleotide polymorphism (SNP) associated...

["Bioinformatics","Mathematical Biology","Statistics"]
doi:10.7287/peerj.preprints.27118v2
688 downloads
789 views

Phylogenetic comparative methods (PCMs), especially ones based on linear models, have played a central role in understanding species’ trait evolution. These methods, however, usually assume that phylogenetic trees are known without error or uncertainty, but this...

["Computational Biology","Evolutionary Studies","Genetics","Taxonomy","Statistics"]
doi:10.7287/peerj.preprints.1216v2
226 downloads
509 views

Background. Ebola Virus Disease (EVD) is a highly infectious disease that has produced over 25,000 cases in the past 50 years. While many past outbreaks resulted in relatively few cases, the 2014 outbreak in West Africa was the most deadly occurrence of EVD to...

["Epidemiology","Infectious Diseases","Statistics"]
doi:10.7287/peerj.preprints.3021v2
81 downloads
109 views

Stream temperature is an important exogenous factor influencing populations of stream organisms such as fish, amphibians, and invertebrates. Many states regulate stream protections based on temperature. Therefore, stream temperature models are important, particularly...

["Aquaculture, Fisheries and Fish Science","Statistics","Freshwater Biology","Natural Resource Management"]
doi:10.7287/peerj.preprints.27069v1
What is a PeerJ Preprint?

A PeerJ Preprint is a draft of an article, abstract, or poster that has not yet been peer-reviewed for formal publication. Submit a draft, incomplete, or final version of your work for free.

Submissions today can be approved by Editorial Staff and online in 24 hours.

Establish precedent. Solicit feedback. Publish updates.

Refine by manuscript type

Top subject areas - Preprints

Top subject areas - People

View all subject areas