Preprints (not yet peer-reviewed)

395 downloads
885 views

Many pressing medical challenges - such as diagnosing disease, enhancing directed stem cell differentiation, and classifying cancers - have long been hindered by limitations in our ability to quantify proteins in single cells. Mass-spectrometry (MS) is poised to...

["Bioengineering","Biotechnology","Cell Biology","Computational Biology","Genomics"]
doi:10.7287/peerj.preprints.26821v2
12 downloads
63 views

The study of how the observable features of organisms, i.e., their phenotypes, result from the complex interplay between genetics, development, and the environment, is central to much research in biology. The varied language used in the description of phenotypes,...

["Biodiversity","Computational Biology","Evolutionary Studies"]
doi:10.7287/peerj.preprints.26988v1
51 downloads
142 views

Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause of disease. Chromosomal amplifications have been identified as a source of upregulation of cervical cancer driver genes but cannot fully explain...

["Computational Biology","Microbiology","Oncology"]
doi:10.7287/peerj.preprints.26957v1
56 downloads
100 views

Flow cytometry (FCM) is a powerful analytical tool that is widely used worldwide, as it allows the depiction of the innate complexity of a vast range of biological systems in few seconds. It is a technique based on the spectroscopic properties of suspended particles...

["Bioinformatics","Computational Biology","Ecology","Ecosystem Science","Data Science"]
doi:10.7287/peerj.preprints.26934v1
153 downloads
327 views

Microbes are identified based on their distinguishing characteristics such as gene sequence or metabolic profile. Nucleic acid approaches such as 16S rRNA gene sequencing provide the gold standard method for microbial identification in the contemporary era. However,...

["Biochemistry","Bioinformatics","Biotechnology","Computational Biology","Microbiology"]
doi:10.7287/peerj.preprints.3524v2
37 downloads
74 views

According to the energy supply/energy depletion model, it is not clear how the depletion of substrates (adenosine triphosphate) affects sprint performance. Therefore, this research was conducted to find out how the human organism regulates the amount and the rate...

["Computational Biology","Mathematical Biology","Global Health","Kinesiology","Nutrition"]
doi:10.7287/peerj.preprints.26919v1
648 downloads
600 views

The rapid increase in volume and complexity of biomedical data requires changes in research, communication, training, and clinical practices. This includes learning how to effectively integrate automated analysis with high-data-density visualizations that clearly...

["Computational Biology","Science and Medical Education","Human-Computer Interaction","Data Science"]
doi:10.7287/peerj.preprints.26896v1
59 downloads
110 views

Xeno-miRNAs are microRNAs originating from exogenous species detected in host biofluids. A growing number of studies have suggested that many of these xeno-miRNAs may be involved in cross-species interactions by targeting host mRNAs. To date, hundreds of xeno-miRNAs...

["Bioinformatics","Computational Biology","Genetics","Genomics","Parasitology"]
doi:10.7287/peerj.preprints.26887v1
56 downloads
187 views

Fine-scale evolutionary dynamics can be challenging to tease out when focused on broad brush strokes of whole populations over long time spans. We propose a suite of diagnostic metrics that operate on lineages and phylogenies in digital evolution experiments with...

["Computational Biology","Adaptive and Self-Organizing Systems","Scientific Computing and Simulation"]
doi:10.7287/peerj.preprints.26883v1
38 downloads
169 views

Protein sites present different amino acids during their evolution, whose number reflects the selective constraints operating on them. This evolutionary variability is strongly influenced by the structural properties of the site in the native structure, and it...

["Bioinformatics","Biophysics","Computational Biology","Evolutionary Studies"]
doi:10.7287/peerj.preprints.26868v1
144 downloads
285 views

Single-cell RNA-seq is revolutionizing our understanding of cell type heterogeneity in many fields of biology, ranging from neuroscience to cancer to immunology. In Immunology, one of the main promises of this approach is the ability to define cell types as clusters...

["Bioinformatics","Computational Biology","Evolutionary Studies","Immunology"]
doi:10.7287/peerj.preprints.26858v1
222 downloads
503 views

Many data include time or have longitudinal dimensionalilty. When these data include an index of time, i.e. measures at regular or periodically successive intervals, statistics that use time sequencing in some capacity are appropriate. Consequently, investing time...

["Bioinformatics","Computational Biology","Data Science"]
doi:10.7287/peerj.preprints.26842v1
204 downloads
426 views

High-throughput sequencing of environmental DNA (eDNA) offers a simple and cost-effective solution for marine biodiversity assessments. Yet several analytical challenges remain, including the incorporation of statistical inference in the assignment of taxonomic...

["Biodiversity","Bioinformatics","Computational Biology","Marine Biology","Data Mining and Machine Learning"]
doi:10.7287/peerj.preprints.26812v1
378 downloads
673 views

Potential Natural Vegetation (PNV) is the vegetation cover in equilibrium with climate, that would exist at a given location non-impacted by human activities. PNV is useful for raising public awareness about land degradation and for estimating land potential. This...

["Biogeography","Computational Biology","Plant Science","Data Mining and Machine Learning","Spatial and Geographic Information Science"]
doi:10.7287/peerj.preprints.26811v1
280 downloads
796 views

The development of methods to estimate rates of speciation and extinction from time- calibrated phylogenies has revolutionized evolutionary biology by allowing researchers to correlate diversification rate shifts with causal ecological factors. A growing number...

["Bioinformatics","Computational Biology","Evolutionary Studies"]
doi:10.7287/peerj.preprints.3206v2
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