Preprints (not yet peer-reviewed)

82 downloads
213 views

Bioinformatics algorithms are now crucial for processing high throughput “-omics” data and deriving meaningful interpretations in most biomedical and life science research domains. Bioinformatics-related training and research mostly take place in nations with higher...

["Bioinformatics","Computational Biology","Genomics","Science and Medical Education"]
doi:10.7287/peerj.preprints.27415v1
92 downloads
180 views

Third generation sequencing methods generate significantly longer reads than those produced using alternative sequencing methods. This provides increased possibilities to better study biodiversity, phylogeography and population genetics. We developed a protocol...

["Biodiversity","Evolutionary Studies","Genomics"]
doi:10.7287/peerj.preprints.27411v1
31 downloads
102 views

Superoxide dismutases (SODs) are a key antioxidant enzyme family, which plays a critical function in plant growth and development. Previously, this gene family has been investigated in Arabidopsis and rice. In the present study, it was the first time for us to...

["Agricultural Science","Bioinformatics","Genomics"]
doi:10.7287/peerj.preprints.27402v1
46 downloads
75 views

Psychiatric disorders present distinct clinical challenges which are partly attributable to their multifactorial aetiology and the absence of laboratory tests that can be used to confirm diagnosis or predict risk. Psychiatric disorders are highly heritable, but...

["Genetics","Genomics","Ethical Issues","Medical Genetics"]
doi:10.7287/peerj.preprints.27392v1
59 downloads
164 views

Background. Metagenomics studies have reported on the complexity of microbiomes associated with seagrass and can provide critical insights into the sustainable use and conservation of seagrasses. Recent conservation activities in Kenya focused mainly on coral reefs...

["Bioinformatics","Ecosystem Science","Genomics","Marine Biology","Natural Resource Management"]
doi:10.7287/peerj.preprints.27387v1
56 downloads
125 views

Neisseria meningitidis (Nm) and N. gonorrhoeae (Ng) are closely related pathogenic bacteria. Using those genes found across 20 Nm and 15 Ng genomes we find that Nm is 7x more diverse than Ng in their combined core genome. Both species have acquired the majority...

["Evolutionary Studies","Genetics","Genomics","Microbiology","Infectious Diseases"]
doi:10.7287/peerj.preprints.27382v1
3,394 downloads
5,372 views

Gene expression is the fundamental level at which the result of various genetic and regulatory programs are observable. The measurement of transcriptome-wide gene expression has convincingly switched from microarrays to sequencing in a matter of years. RNA sequencing...

["Bioinformatics","Computational Biology","Genomics","Data Science"]
doi:10.7287/peerj.preprints.27283v2
229 downloads
359 views

The rapid decrease in DNA sequencing cost is revolutionizing medicine and science. In medicine, genome sequencing has revealed millions of missense variants that change protein sequences, yet we only understand the molecular and phenotypic consequences of a small...

["Bioinformatics","Biophysics","Computational Biology","Genomics","Medical Genetics"]
doi:10.7287/peerj.preprints.27379v1
25 downloads
101 views

Introduction. Whole-metagenome sequencing can be a rich source of information about the structure and function of entire metagenomic communities, but getting accurate and reliable results from these datasets can be challenging. Analysis of these datasets is founded...

["Bioinformatics","Ecology","Genomics","Microbiology"]
doi:10.7287/peerj.preprints.27376v1
61 downloads
94 views

Cell walls play an important role in the structure and morphology of plants as well as stress response, including various biotic and abiotic stresses. Although the comprehensive analysis of genes involved in cellulose synthase have been performed in model plants,...

["Genomics","Plant Science"]
doi:10.7287/peerj.preprints.27374v1
53 downloads
201 views

Photoperiodic flowering aligns plant reproduction to favourable seasons of the year to maximise successful production of seeds and grains. However understanding of this process in the temperate legumes of the Fabaceae family, which are important both agriculturally...

["Bioinformatics","Genomics","Molecular Biology","Plant Science"]
doi:10.7287/peerj.preprints.27366v1
169 downloads
224 views

Bioinformatics is an interdisciplinary field that develops software methods and tools to understand biological data. Actually, in branches such as genomics, there are a large number of software tools that serve to support different processes such as genetic data...

["Bioinformatics","Genomics","Computational Science"]
doi:10.7287/peerj.preprints.27352v3
66 downloads
143 views

Nowadays, the analysis of RNA-seq and BS-Seq can be considered well established, whereas the analysis of broad peaks data as Sono-Seq/ATAC-Seq and histone modification (HM) ChIP-Seq is still challenging. To fill the gap in existing methods, we present DEScan2 a...

["Bioinformatics","Genomics"]
doi:10.7287/peerj.preprints.27357v1
27 downloads
77 views

Explaining the variability in drug sensitivity across a panel of cell lines using genomic information is a key aspect of cancer drug discovery. The results of such analyses may ultimately determine which patients are likely to benefit from a new treatment. There...

["Bioinformatics","Computational Biology","Genomics","Drugs and Devices","Oncology"]
doi:10.7287/peerj.preprints.27345v1
59 downloads
160 views

The advent of Next Generation Sequencing has reduced sequencing costs and increased genomic projects from a huge amount of organismal taxa, generating an unprecedented amount of genomic datasets publicly available. Often, only a tiny fraction of outstanding relevance...

["Biodiversity","Bioinformatics","Entomology","Evolutionary Studies","Genomics"]
doi:10.7287/peerj.preprints.27342v1
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