Preprints (not yet peer-reviewed)

17 downloads
55 views

This detailed analysis provides an insight into aging processes in the human organism. The developmental program that controls the regulation of gene expression through epigenetic modifications leads to cellular senescence in the latter life. This epigenetic development...

["Cell Biology","Developmental Biology","Genetics","Molecular Biology"]
doi:10.7287/peerj.preprints.26998v1
43 downloads
339 views

Human primary T cells are invaluable and feasible model systems to study the characteristics of the immune cells in various contexts, including but not limited to cancer immunotherapy. Following isolation of T cells from fresh human blood samples, it is possible...

["Cell Biology","Genetics","Molecular Biology","Immunology"]
doi:10.7287/peerj.preprints.26993v1
430 downloads
959 views

Many pressing medical challenges - such as diagnosing disease, enhancing directed stem cell differentiation, and classifying cancers - have long been hindered by limitations in our ability to quantify proteins in single cells. Mass-spectrometry (MS) is poised to...

["Bioengineering","Biotechnology","Cell Biology","Computational Biology","Genomics"]
doi:10.7287/peerj.preprints.26821v2
128 downloads
183 views

The existence of eukaryotic ribosomes with distinct ribosomal protein (RP) stoichiometry and regulatory roles in protein synthesis been speculated for over sixty years. Recent advances in mass spectrometry and high throughput analysis have begun to identify and...

["Biochemistry","Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.26991v1
16 downloads
80 views

Intact biomolecules carry its identity through its atomic constituents and mass, while fragmented biomolecules require reconstruction for their identity to be retrieved. Hence, for profiling biomolecules in mixtures, the goal would be the gentle ionization of biomolecules...

["Biochemistry","Bioengineering","Biophysics","Biotechnology","Cell Biology"]
doi:10.7287/peerj.preprints.26983v1
28 downloads
96 views

Growth in minimal salts medium meant that a microorganism has the full repertoire of biosynthetic machinery for surviving in habitats lacking in vitamins and growth factors. This significantly expands the types of habitats suitable for colonization by the microbe....

["Biochemistry","Biotechnology","Cell Biology","Ecology","Microbiology"]
doi:10.7287/peerj.preprints.26970v1
160 downloads
325 views

The cellular abundance of proteins can vary even between isogenic single cells. This variability between single-cell protein levels can have functional roles, such as controlling cell fate during apoptosis induction or the proliferation/quiescence decision. Here,...

["Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.26965v1
123 downloads
77 views

LB Lennox medium is commonly used for bacterial cell culture, but the amount of biomass obtained while sufficient for molecular biology and biochemical studies, is insufficient for applied microbiology research. Thus, supplementation of LB Lennox with glucose is...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.26949v1
62 downloads
107 views

Circular RNA (CircRNA) is an endogenous noncoding RNA with covalently closed cyclic structure. It is divided into exonic circRNA, intronic circRNA and exon-intron circRNA, based on their components. CircRNAs are well conserved in sequence and abundantly expressed...

["Biochemistry","Cell Biology"]
doi:10.7287/peerj.preprints.26936v1
78 downloads
140 views

Background. We sought to examine how 12 weeks of resistance exercise training (RET) affected skeletal muscle myofibrillar and sarcoplasmic protein levels along with markers of mitochondrial physiology in high versus low anabolic responders. Methods. Untrained college-aged...

["Cell Biology","Kinesiology"]
doi:10.7287/peerj.preprints.26933v1
22 downloads
103 views

Proteolysis is increasingly documented as a method of regulation of mitochondrial function. Our studies of rhomboidfamily proteins’ roles in organelles show that this is also the case in the social amoeba Dictyostelium discoideum, in which four of these membrane-bound,...

["Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26930v1
36 downloads
119 views

Coping with nutritional stress is essential for cell survival, of which many strategies at the cellular level lend support for ensuring the survival of the population at a particular habitat. One postulated mechanism is swarming motility in bacterial cells, where,...

["Biochemistry","Bioengineering","Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26914v1
61 downloads
140 views

Euglena gracilis is an edible photosynthetic single-cell alga that can synthesize carotenoids. It is highly demanded to establish the technology to select and grow individual cells capable of synthesizing more carotenoids because it contributes to safe and inexpensive...

["Cell Biology","Microbiology","Plant Science","Freshwater Biology"]
doi:10.7287/peerj.preprints.26906v1
76 downloads
124 views

Temperature affects growth of bacteria by influencing enzyme and growth kinetics. Specifically, evolution selects for specific temperature range in which a microbe could thrive, and thus fix the temperature range in which biomolecule structure and function are...

["Biochemistry","Biotechnology","Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26901v1
63 downloads
307 views

Survival of microbes on various surfaces and habitats is a question of importance to basic science, as well as health care, water treatment and distribution, ecology, and search for life in other planetary bodies. To this end, various model organisms known to be...

["Biochemistry","Biotechnology","Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.3103v2
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