Preprints (not yet peer-reviewed)

9 downloads
43 views

Microbes live in communities known as biofilm on many surfaces. Thus, understanding the spatially-resolved intercellular communication and signalling link would be important to elucidate the fundamental mechanisms that govern the division of labour within biofilm...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.27117v1
19 downloads
81 views

This study focused on the alterations that occur in larval molluscan cells during the induction or inhibition of apoptosis both in standard culture conditions and in response to cold injury during the induction of different death pathways. This is the first report...

["Cell Biology","Marine Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.27100v1
35 downloads
131 views

Programmed cell death signaling networks are frequently activated to coordinate the process of cell differentiation, and a variety of apoptotic events can mediate the process. This can include the ligation of death receptors, the activation of downstream caspases,...

["Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.27080v1
45 downloads
121 views

Trichomes, specialized cells that form on the above ground parts of plants, are useful model systems for studying cell differentiation. In this study, the plant hormone ethylene was found to strongly inhibit formation of trichomes on stems of Arabidopsis thaliana....

["Cell Biology","Developmental Biology","Plant Science"]
doi:10.7287/peerj.preprints.27047v1
30 downloads
108 views

Characterized by high blood glucose concentration, resistance of cells to glucose uptake and reduced insulin sensitivity, Type II diabetes is a major health problem afflicting both developing and developed countries in increasing extent as populations around the...

["Biochemistry","Cell Biology","Diabetes and Endocrinology","Internal Medicine","Metabolic Sciences"]
doi:10.7287/peerj.preprints.27024v1
23 downloads
88 views

Large culture volume in bioreactor necessitates aeration for providing sufficient oxygen for cell growth. Thus, extend of aeration and amount of anti-foam needed for suppressing foam formation are key parameters determining the success of bioreactor fermentation....

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.27014v1
61 downloads
161 views

GDF11, a member of TGF-β superfamily, has recently received widespread attention as a novel anti-ageing/rejuvenation factor to reverse age-related dysfunctions in heart and skeletal muscle, and to induce angiogenesis and neurogenesis. However, these positive effects...

["Biochemistry","Bioinformatics","Cell Biology","Neuroscience","Evidence Based Medicine"]
doi:10.7287/peerj.preprints.27003v1
70 downloads
144 views

This detailed analysis provides an insight into aging processes in the human organism. The developmental program that controls the regulation of gene expression through epigenetic modifications leads to cellular senescence in the latter life. This epigenetic development...

["Cell Biology","Developmental Biology","Genetics","Molecular Biology"]
doi:10.7287/peerj.preprints.26998v1
116 downloads
448 views

Human primary T cells are invaluable and feasible model systems to study the characteristics of the immune cells in various contexts, including but not limited to cancer immunotherapy. Following isolation of T cells from fresh human blood samples, it is possible...

["Cell Biology","Genetics","Molecular Biology","Immunology"]
doi:10.7287/peerj.preprints.26993v1
622 downloads
1,251 views

Many pressing medical challenges - such as diagnosing disease, enhancing directed stem cell differentiation, and classifying cancers - have long been hindered by limitations in our ability to quantify proteins in single cells. Mass-spectrometry (MS) is poised to...

["Bioengineering","Biotechnology","Cell Biology","Computational Biology","Genomics"]
doi:10.7287/peerj.preprints.26821v2
248 downloads
328 views

The existence of eukaryotic ribosomes with distinct ribosomal protein (RP) stoichiometry and regulatory roles in protein synthesis been speculated for over sixty years. Recent advances in mass spectrometry and high throughput analysis have begun to identify and...

["Biochemistry","Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.26991v1
24 downloads
112 views

Intact biomolecules carry its identity through its atomic constituents and mass, while fragmented biomolecules require reconstruction for their identity to be retrieved. Hence, for profiling biomolecules in mixtures, the goal would be the gentle ionization of biomolecules...

["Biochemistry","Bioengineering","Biophysics","Biotechnology","Cell Biology"]
doi:10.7287/peerj.preprints.26983v1
34 downloads
135 views

Growth in minimal salts medium meant that a microorganism has the full repertoire of biosynthetic machinery for surviving in habitats lacking in vitamins and growth factors. This significantly expands the types of habitats suitable for colonization by the microbe....

["Biochemistry","Biotechnology","Cell Biology","Ecology","Microbiology"]
doi:10.7287/peerj.preprints.26970v1
308 downloads
464 views

The cellular abundance of proteins can vary even between isogenic single cells. This variability between single-cell protein levels can have functional roles, such as controlling cell fate during apoptosis induction or the proliferation/quiescence decision. Here,...

["Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.26965v1
166 downloads
107 views

LB Lennox medium is commonly used for bacterial cell culture, but the amount of biomass obtained while sufficient for molecular biology and biochemical studies, is insufficient for applied microbiology research. Thus, supplementation of LB Lennox with glucose is...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.26949v1
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