Preprints (not yet peer-reviewed)

35 downloads
69 views

Describing cell morphology is a tricky task, prone to misinterpretation due to subjective nature of the human observer and his vocabulary limitations. Consequently, these limitations actuate prevalence of non-formalized, statistically unverifiable language use....

["Bioinformatics","Cell Biology","Computational Biology","Marine Biology","Mathematical Biology"]
doi:10.7287/peerj.preprints.27271v2
21 downloads
78 views

The fractal formalism in combination with linear image analysis enables statistically significant description and classification of “irregular” (in terms of Euclidean geometry) shapes, such as, outlines of in vitro flattened cells. We developed an optimal model...

["Bioinformatics","Cell Biology","Computational Biology","Marine Biology"]
doi:10.7287/peerj.preprints.27258v1
224 downloads
477 views

The actin cytoskeleton comprises a set of filament networks that perform essential functions in eukaryotic cells. The idea that actin filaments incorporate monomers directly from solution forms both the “textbook picture” of filament elongation and a conventional...

["Biochemistry","Biophysics","Cell Biology"]
doi:10.7287/peerj.preprints.27254v1
49 downloads
183 views

Genomic instability can manifest due to both chromosomal rearrangements and gain and loss of entire chromosomes. One mechanism by which a carcinogen acts is by increasing the rate of mitotic spindle defects during proliferation. These defects can lead to chromosomal...

["Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.27177v1
338 downloads
744 views

The microbe-stuffed gut, rather than the genome, represents the most dynamic gene reservoir within complex, multicellular metazoa (animals). Microbes are known to confer increased metabolic efficiency, increased nutrient recovery, and tolerance of ocean acidity...

["Cell Biology","Evolutionary Studies"]
doi:10.7287/peerj.preprints.27173v1
51 downloads
161 views

Background. Insufficient quantities of freshly harvested Limnoperna fortunei gametes and embryos constrain reproduction research in the laboratory. Cryopreservation would allow the accumulation and storage of gametes when they are available. The lack of available...

["Aquaculture, Fisheries and Fish Science","Cell Biology"]
doi:10.7287/peerj.preprints.27165v2
36 downloads
115 views

Tropomodulins (Tmods) are proteins that cap the slow growing (pointed) ends of actin filaments (F-actin). The basis for our current understanding of Tmod function comes from studies in cells with relatively stable and highly organized F-actin networks, leading...

["Biochemistry","Cell Biology","Molecular Biology","Anatomy and Physiology","Diabetes and Endocrinology"]
doi:10.7287/peerj.preprints.27172v1
78 downloads
175 views

Background. Mesenchymal stem/stromal cells (MSCs) are a promising tool for cell-based therapies in the treatment of tissue injury. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis plays a significant role in directing MSC homing to...

["Cell Biology","Mathematical Biology","Drugs and Devices"]
doi:10.7287/peerj.preprints.27144v1
55 downloads
100 views

Microbes live in communities known as biofilm on many surfaces. Thus, understanding the spatially-resolved intercellular communication and signalling link would be important to elucidate the fundamental mechanisms that govern the division of labour within biofilm...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.27117v1
45 downloads
132 views

This study focused on the alterations that occur in larval molluscan cells during the induction or inhibition of apoptosis both in standard culture conditions and in response to cold injury during the induction of different death pathways. This is the first report...

["Cell Biology","Marine Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.27100v1
57 downloads
196 views

Programmed cell death signaling networks are frequently activated to coordinate the process of cell differentiation, and a variety of apoptotic events can mediate the process. This can include the ligation of death receptors, the activation of downstream caspases,...

["Cell Biology","Molecular Biology"]
doi:10.7287/peerj.preprints.27080v1
74 downloads
173 views

Trichomes, specialized cells that form on the above ground parts of plants, are useful model systems for studying cell differentiation. In this study, the plant hormone ethylene was found to strongly inhibit formation of trichomes on stems of Arabidopsis thaliana....

["Cell Biology","Developmental Biology","Plant Science"]
doi:10.7287/peerj.preprints.27047v1
47 downloads
147 views

Characterized by high blood glucose concentration, resistance of cells to glucose uptake and reduced insulin sensitivity, Type II diabetes is a major health problem afflicting both developing and developed countries in increasing extent as populations around the...

["Biochemistry","Cell Biology","Diabetes and Endocrinology","Internal Medicine","Metabolic Sciences"]
doi:10.7287/peerj.preprints.27024v1
43 downloads
109 views

Large culture volume in bioreactor necessitates aeration for providing sufficient oxygen for cell growth. Thus, extend of aeration and amount of anti-foam needed for suppressing foam formation are key parameters determining the success of bioreactor fermentation....

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.27014v1
83 downloads
247 views

GDF11, a member of TGF-β superfamily, has recently received widespread attention as a novel anti-ageing/rejuvenation factor to reverse age-related dysfunctions in heart and skeletal muscle, and to induce angiogenesis and neurogenesis. However, these positive effects...

["Biochemistry","Bioinformatics","Cell Biology","Neuroscience","Evidence Based Medicine"]
doi:10.7287/peerj.preprints.27003v1
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