Preprints (not yet peer-reviewed)

430 downloads
959 views

Many pressing medical challenges - such as diagnosing disease, enhancing directed stem cell differentiation, and classifying cancers - have long been hindered by limitations in our ability to quantify proteins in single cells. Mass-spectrometry (MS) is poised to...

["Bioengineering","Biotechnology","Cell Biology","Computational Biology","Genomics"]
doi:10.7287/peerj.preprints.26821v2
16 downloads
80 views

Intact biomolecules carry its identity through its atomic constituents and mass, while fragmented biomolecules require reconstruction for their identity to be retrieved. Hence, for profiling biomolecules in mixtures, the goal would be the gentle ionization of biomolecules...

["Biochemistry","Bioengineering","Biophysics","Biotechnology","Cell Biology"]
doi:10.7287/peerj.preprints.26983v1
65 downloads
174 views

Clustered regularly interspersed short palindromic repeats (CRISPR) is a natural defense system for bacteria and archaea against foreign DNA and RNA. Specifically, short snippets of foreign DNA or RNA are incorporated into protospacer adjacent motif (PAM) repeats...

["Biochemistry","Bioengineering","Biotechnology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26975v1
28 downloads
96 views

Growth in minimal salts medium meant that a microorganism has the full repertoire of biosynthetic machinery for surviving in habitats lacking in vitamins and growth factors. This significantly expands the types of habitats suitable for colonization by the microbe....

["Biochemistry","Biotechnology","Cell Biology","Ecology","Microbiology"]
doi:10.7287/peerj.preprints.26970v1
46 downloads
93 views

Overweight and obesity are considered as a major cause of various conditions related to metabolic syndrome. Yet, considering the complex interacting factors leading to pathogenicity and underlying mechanisms, it remains a poorly defined area. Some probiotics have...

["Biotechnology","Microbiology"]
doi:10.7287/peerj.preprints.26959v1
123 downloads
77 views

LB Lennox medium is commonly used for bacterial cell culture, but the amount of biomass obtained while sufficient for molecular biology and biochemical studies, is insufficient for applied microbiology research. Thus, supplementation of LB Lennox with glucose is...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.26949v1
90 downloads
470 views

Background. Carnivorous plants have been fascinating researchers with their unique characters and bioinspired applications. These include medicinal trait of some carnivorous plants with potentials for pharmaceutical industry. Methods. This review will cover recent...

["Biochemistry","Biotechnology","Genomics","Plant Science"]
doi:10.7287/peerj.preprints.26940v1
159 downloads
332 views

Microbes are identified based on their distinguishing characteristics such as gene sequence or metabolic profile. Nucleic acid approaches such as 16S rRNA gene sequencing provide the gold standard method for microbial identification in the contemporary era. However,...

["Biochemistry","Bioinformatics","Biotechnology","Computational Biology","Microbiology"]
doi:10.7287/peerj.preprints.3524v2
60 downloads
205 views

Didymosphenia geminata (D. geminata) in Chilean rivers is a complex problem. Its biology and effects on ecosystems is still being studied, at the moment not research has focused on its D. geminata effects at the cellular level. We developed an artificial river...

["Biotechnology","Freshwater Biology","Ecohydrology"]
doi:10.7287/peerj.preprints.26880v2
76 downloads
124 views

Temperature affects growth of bacteria by influencing enzyme and growth kinetics. Specifically, evolution selects for specific temperature range in which a microbe could thrive, and thus fix the temperature range in which biomolecule structure and function are...

["Biochemistry","Biotechnology","Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.26901v1
35 downloads
125 views

Ribosomes are highly conserved macromolecular machines whose critical function is protein synthesis. However, existence of unique molecular mass of the same type of ribosomal protein for individual species in the same domain of life raises the interesting question...

["Biochemistry","Biodiversity","Bioinformatics","Biotechnology","Ecology"]
doi:10.7287/peerj.preprints.26878v1
63 downloads
307 views

Survival of microbes on various surfaces and habitats is a question of importance to basic science, as well as health care, water treatment and distribution, ecology, and search for life in other planetary bodies. To this end, various model organisms known to be...

["Biochemistry","Biotechnology","Cell Biology","Microbiology","Molecular Biology"]
doi:10.7287/peerj.preprints.3103v2
40 downloads
264 views

We present PromoterPredict, a dynamic multiple regression approach to predict the strength of Escherichia coli promoters binding the σ70 factor of RNA polymerase. σ70 promoters are ubiquitously used in recombinant DNA technology, but characterizing their strength...

["Bioengineering","Bioinformatics","Biotechnology","Data Mining and Machine Learning"]
doi:10.7287/peerj.preprints.26759v2
36 downloads
130 views

Polyethylene glycol is commonly used in fermentations as an anti-foam for preventing the rise of foam to the top plate of the bioreactor, which increases contamination risk. However, its potential toxicity to growth of various microorganisms is not well understood...

["Biochemistry","Bioengineering","Biotechnology","Cell Biology","Microbiology"]
doi:10.7287/peerj.preprints.26817v1
48 downloads
235 views

Background. Entolimod is a Salmonella enterica flagellin derivate. Previous work has demonstrated that entolimod effectively protects mice and non-human primates from ionizing radiation. However, it caused a “flu-like” syndrome after radioprotective and anticancer...

["Biochemistry","Bioengineering","Biotechnology"]
doi:10.7287/peerj.preprints.26803v1
What is a PeerJ Preprint?

A PeerJ Preprint is a draft of an article, abstract, or poster that has not yet been peer-reviewed for formal publication. Submit a draft, incomplete, or final version of your work for free.

Submissions today can be approved by Editorial Staff and online in 24 hours.

Establish precedent. Solicit feedback. Publish updates.

Refine by manuscript type

Top subject areas - Preprints

Top subject areas - People

View all subject areas